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Ap2b1 Ap2b1 Aadacl4fm5 Aadacl4fm5 Aadacl4fm1 Aadacl4fm1 Pcsk9 Pcsk9 Apoa5 Apoa5 Ap2m1 Ap2m1 Furin Furin Gpihbp1 Gpihbp1 Npc2 Npc2 Apoc1 Apoc1 Pcsk4 Pcsk4 Apoc3 Apoc3 Ap2a2 Ap2a2 Clta Clta ENSMAUP00000022314 ENSMAUP00000022314 Pdia2 Pdia2 Apoc2-2 Apoc2-2 Ap2s1 Ap2s1 Ldlrap1 Ldlrap1 Apoa4 Apoa4 Ildr2 Ildr2 P4hb P4hb Ldlr Ldlr Apoa1 Apoa1 Hdlbp Hdlbp ENSMAUP00000019431 ENSMAUP00000019431 Lsr Lsr Lpl Lpl Cetp Cetp Apof Apof LOC101843823 LOC101843823 A2m A2m Apoa2 Apoa2 Soat2 Soat2 Ptchd3 Ptchd3 Apoe Apoe Cubn Cubn Ces3 Ces3 Angptl4 Angptl4 Sar1b Sar1b Gm10267 Gm10267 Pcsk6 Pcsk6 Angptl8 Angptl8 Mylip Mylip Apoc2 Apoc2 Abca1 Abca1 Lipc Lipc Smpdl3a Smpdl3a Zdhhc19 Zdhhc19 Ptchd4 Ptchd4 Pltp Pltp Lmf1 Lmf1 LOC101841643 LOC101841643 Pzp Pzp Nr1h2 Nr1h2 Npc1 Npc1 Pcsk5 Pcsk5 Mttp Mttp Apob Apob Abcg1 Abcg1 Cltc Cltc ENSMAUP00000007258 ENSMAUP00000007258 Scarb1 Scarb1 Lcat Lcat Nr1h3 Nr1h3 Soat1 Soat1 Apon Apon Aadacl4fm4 Aadacl4fm4 Aadacl3 Aadacl3 LOC101823019 LOC101823019 Cdcp2 Cdcp2 Rps27a Rps27a Plekhd1 Plekhd1 Angptl3 Angptl3 Sar1a Sar1a Ap2a1 Ap2a1 Prkaca Prkaca Clhc1 Clhc1 Lipa Lipa Plg Plg Prkacb Prkacb Kxd1 Kxd1 Ptchd1 Ptchd1 ENSMAUP00000002256 ENSMAUP00000002256 Lmf2 Lmf2 Alb Alb Bmp1 Bmp1 Vldlr Vldlr Nceh1 Nceh1 A2ml1 A2ml1 Zdhhc8 Zdhhc8 Lipg Lipg
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ap2b1AP complex subunit beta. (951 aa)
Aadacl4fm5Arylacetamide deacetylase-like 4 isoform X1. (387 aa)
Aadacl4fm1Arylacetamide deacetylase-like 4. (388 aa)
Pcsk9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (676 aa)
Apoa5Apolipoprotein A-V. (363 aa)
Ap2m1AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family. (441 aa)
FurinFurin; Belongs to the peptidase S8 family. (794 aa)
Gpihbp1Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform X2. (229 aa)
Npc2Epididymal secretory protein E1. (149 aa)
Apoc1Apolipoprotein C-I. (88 aa)
Pcsk4LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (639 aa)
Apoc3Apolipoprotein C-III. (53 aa)
Ap2a2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
CltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
ENSMAUP00000022314annotation not available (101 aa)
Pdia2Protein disulfide-isomerase A2. (531 aa)
Apoc2-2Apolipoprotein C-II isoform X5. (124 aa)
Ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
Ldlrap1Low density lipoprotein receptor adapter protein 1. (307 aa)
Apoa4Apolipoprotein A-IV. (267 aa)
Ildr2Immunoglobulin-like domain-containing receptor 2 isoform X2. (608 aa)
P4hbProtein disulfide-isomerase. (509 aa)
LdlrLow-density lipoprotein receptor isoform X1. (856 aa)
Apoa1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (264 aa)
HdlbpVigilin. (1268 aa)
ENSMAUP00000019431annotation not available (150 aa)
LsrLipolysis-stimulated lipoprotein receptor isoform X1. (592 aa)
LplLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (474 aa)
CetpCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (494 aa)
ApofLOW QUALITY PROTEIN: apolipoprotein F. (314 aa)
LOC101843823Alpha-1-inhibitor 3-like. (803 aa)
A2mAlpha-2-macroglobulin-like. (1140 aa)
Apoa2Apolipoprotein A-II. (101 aa)
Soat2O-acyltransferase. (521 aa)
Ptchd3Patched domain-containing protein 3. (891 aa)
ApoeApolipoprotein E. (314 aa)
CubnCubilin. (2791 aa)
Ces3Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (570 aa)
Angptl4Angiopoietin-related protein 4. (411 aa)
Sar1bGTP-binding protein SAR1b; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
Gm10267Double-headed protease inhibitor, submandibular gland-like. (83 aa)
Pcsk6Proprotein convertase subtilisin/kexin type 6 isoform X1; Belongs to the peptidase S8 family. (949 aa)
Angptl8Angiopoietin-like protein 8. (198 aa)
MylipE3 ubiquitin-protein ligase MYLIP isoform X1. (445 aa)
Apoc2Apolipoprotein C-II isoform X1. (100 aa)
Abca1ATP-binding cassette sub-family A member 1 isoform X2. (2261 aa)
LipcHepatic triacylglycerol lipase isoform X2. (538 aa)
Smpdl3aAcid sphingomyelinase-like phosphodiesterase. (450 aa)
Zdhhc19Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (252 aa)
Ptchd4Patched domain-containing protein 4 isoform X2. (901 aa)
PltpPhospholipid transfer protein. (493 aa)
Lmf1Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (323 aa)
LOC101841643Arylacetamide deacetylase-like 4. (406 aa)
PzpPregnancy zone protein-like. (1479 aa)
Nr1h2Oxysterols receptor LXR-beta isoform X1. (442 aa)
Npc1Niemann-Pick C1 protein. (1277 aa)
Pcsk5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (889 aa)
MttpMicrosomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (895 aa)
ApobApolipoprotein B-100. (4488 aa)
Abcg1ATP-binding cassette sub-family G member 1 isoform X1. (666 aa)
CltcClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
ENSMAUP00000007258annotation not available (117 aa)
Scarb1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (509 aa)
LcatPhosphatidylcholine-sterol acyltransferase. (248 aa)
Nr1h3Oxysterols receptor LXR-alpha isoform X1. (296 aa)
Soat1O-acyltransferase. (546 aa)
AponUncharacterized LOC101832433. (233 aa)
Aadacl4fm4AADACL4 family member 4. (334 aa)
Aadacl3Arylacetamide deacetylase-like 3. (408 aa)
LOC101823019Ubiquitin-like. (114 aa)
Cdcp2CUB domain-containing protein 2. (421 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
Plekhd1Pleckstrin homology domain-containing family D member 1. (496 aa)
Angptl3Angiopoietin-related protein 3. (460 aa)
Sar1aGTP-binding protein SAR1a; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
Ap2a1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Clhc1Clathrin heavy chain linker domain-containing protein 1. (585 aa)
LipaLipase; Belongs to the AB hydrolase superfamily. Lipase family. (397 aa)
PlgPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (797 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
Ptchd1Patched domain-containing protein 1. (888 aa)
ENSMAUP00000002256annotation not available (75 aa)
Lmf2Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (699 aa)
AlbSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (530 aa)
Bmp1Metalloendopeptidase. (991 aa)
VldlrVery low-density lipoprotein receptor isoform X1. (510 aa)
Nceh1Neutral cholesterol ester hydrolase 1. (408 aa)
A2ml1Ovostatin homolog. (1424 aa)
Zdhhc8Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (762 aa)
LipgEndothelial lipase. (502 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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