STRINGSTRING
Mapk11 Mapk11 Cdkn2d Cdkn2d Suz12 Suz12 Kxd1 Kxd1 Cdkn2a Cdkn2a Map2k7 Map2k7 Nrk Nrk Txn1 Txn1 LOC106023108 LOC106023108 Mapkapk3 Mapkapk3 Mapkapk2 Mapkapk2 Map3k15 Map3k15 Mapk8 Mapk8 Jun Jun ENSMAUP00000005256 ENSMAUP00000005256 Nptx1 Nptx1 Txndc8 Txndc8 Rps27a Rps27a Ezh1 Ezh1 ENSMAUP00000005944 ENSMAUP00000005944 LOC101823019 LOC101823019 Ezh2 Ezh2 ENSMAUP00000007258 ENSMAUP00000007258 Rbbp7 Rbbp7 ENSMAUP00000007717 ENSMAUP00000007717 LOC101842493 LOC101842493 Map4k4 Map4k4 Cdk4 Cdk4 Phc2 Phc2 Mapk3 Mapk3 ENSMAUP00000012323 ENSMAUP00000012323 Cbx2 Cbx2 Kdm6b Kdm6b Mov10 Mov10 Rbbp4 Rbbp4 Mapkapk5 Mapkapk5 Fosl2 Fosl2 Mapk14 Mapk14 Tnrc6b Tnrc6b Nme8 Nme8 Mapk10 Mapk10 Mapk1 Mapk1 Mapk9 Mapk9 Map3k6 Map3k6 LOC101839356 LOC101839356 Nptx2 Nptx2 ENSMAUP00000019419 ENSMAUP00000019419 ENSMAUP00000019431 ENSMAUP00000019431 ENSMAUP00000019554 ENSMAUP00000019554 Map3k5 Map3k5 Eed Eed Fos Fos Cdkn2c Cdkn2c Mink1 Mink1 Cdkn2b Cdkn2b ENSMAUP00000022314 ENSMAUP00000022314 Map2k3 Map2k3 Tnik Tnik Map2k6 Map2k6 Cdk6 Cdk6 Cbx6 Cbx6 Map2k4 Map2k4 MDM2 MDM2 Tp53 Tp53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mapk11Mitogen-activated protein kinase. (355 aa)
Cdkn2dCyclin-dependent kinase 4 inhibitor D. (166 aa)
Suz12Polycomb protein SUZ12. (726 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
Cdkn2aCyclin-dependent kinase inhibitor 2A. (157 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (520 aa)
NrkNik-related protein kinase. (357 aa)
Txn1Thioredoxin; Belongs to the thioredoxin family. (105 aa)
LOC106023108Polyhomeotic-like protein 1. (41 aa)
Mapkapk3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
Mapkapk2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (386 aa)
Map3k15Mitogen-activated protein kinase kinase kinase 15. (1197 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
ENSMAUP00000005256annotation not available (73 aa)
Nptx1Neuronal pentraxin-1. (432 aa)
Txndc8Thioredoxin domain-containing protein 8. (152 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
Ezh1Histone-lysine N-methyltransferase EZH1. (747 aa)
ENSMAUP00000005944annotation not available (404 aa)
LOC101823019Ubiquitin-like. (114 aa)
Ezh2Histone-lysine N-methyltransferase EZH2 isoform X2. (745 aa)
ENSMAUP00000007258annotation not available (117 aa)
Rbbp7Histone-binding protein RBBP7. (425 aa)
ENSMAUP00000007717annotation not available (351 aa)
LOC101842493Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (236 aa)
Map4k4Mitogen-activated protein kinase kinase kinase kinase 4 isoform X13. (1289 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Phc2Polyhomeotic-like protein 2 isoform X1. (323 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
ENSMAUP00000012323annotation not available (353 aa)
Cbx2Chromobox protein homolog 2. (518 aa)
Kdm6bLysine-specific demethylase 6B isoform X4. (1652 aa)
Mov10Putative helicase MOV-10 isoform X1. (1077 aa)
Rbbp4RB binding protein 4, chromatin remodeling factor. (391 aa)
Mapkapk5MAP kinase-activated protein kinase 5. (392 aa)
Fosl2Fos-related antigen 2. (324 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Tnrc6bTrinucleotide repeat-containing gene 6B protein. (1805 aa)
Nme8Thioredoxin domain-containing protein 3 isoform X1. (586 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
Map3k6Mitogen-activated protein kinase kinase kinase 6 isoform X1. (1289 aa)
LOC101839356Histone H2B; Belongs to the histone H2B family. (126 aa)
Nptx2Neuronal pentraxin-2. (432 aa)
ENSMAUP00000019419annotation not available (406 aa)
ENSMAUP00000019431annotation not available (150 aa)
ENSMAUP00000019554annotation not available (231 aa)
Map3k5Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1381 aa)
EedPolycomb protein EED. (361 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
Cdkn2cCyclin-dependent kinase 4 inhibitor C. (168 aa)
Mink1Misshapen-like kinase 1 isoform X7. (1319 aa)
Cdkn2bCyclin-dependent kinase 4 inhibitor B isoform X1. (130 aa)
ENSMAUP00000022314annotation not available (101 aa)
Map2k3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
TnikTRAF2 and NCK-interacting protein kinase. (538 aa)
Map2k6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
Cdk6Cyclin-dependent kinase 6. (203 aa)
Cbx6Neuronal pentraxin receptor. (471 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4 isoform X2; Belongs to the protein kinase superfamily. (131 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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