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| | Cdkn2a | Cyclin-dependent kinase inhibitor 2A. (157 aa) |
| | Mapk11 | Mitogen-activated protein kinase. (355 aa) |
| | Tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa) |
| | Ube2d1 | Ubiquitin-conjugating enzyme E2 D1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa) |
| | Ehmt2 | Histone-lysine N-methyltransferase EHMT2 isoform X2. (1249 aa) |
| | Nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (556 aa) |
| | Map2k4 | Dual specificity mitogen-activated protein kinase kinase 4 isoform X2; Belongs to the protein kinase superfamily. (131 aa) |
| | Ubn1 | Ubinuclein-1 isoform X1. (1061 aa) |
| | Cbx6 | Neuronal pentraxin receptor. (471 aa) |
| | Cdk6 | Cyclin-dependent kinase 6. (203 aa) |
| | Map2k6 | Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa) |
| | Tnik | TRAF2 and NCK-interacting protein kinase. (538 aa) |
| | Rb1 | Retinoblastoma-associated protein. (906 aa) |
| | Cdc23 | Cell division cycle protein 23 homolog. (580 aa) |
| | Gm4881 | Uncharacterized protein LOC101827640. (353 aa) |
| | Anapc7 | Anaphase-promoting complex subunit 7. (540 aa) |
| | Map2k3 | Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | Hlx | H2.0-like homeobox protein. (476 aa) |
| | Asf1b | Histone chaperone ASF1B. (201 aa) |
| | Lmnb2 | lamin-B2 isoform X1; Belongs to the intermediate filament family. (596 aa) |
| | ENSMAUP00000022314 | annotation not available (101 aa) |
| | Cdkn2b | Cyclin-dependent kinase 4 inhibitor B isoform X1. (130 aa) |
| | Mink1 | Misshapen-like kinase 1 isoform X7. (1319 aa) |
| | Cdc26 | Anaphase-promoting complex subunit CDC26. (85 aa) |
| | Cdkn2c | Cyclin-dependent kinase 4 inhibitor C. (168 aa) |
| | Fos | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa) |
| | Cdk2 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa) |
| | Anapc15 | Anaphase-promoting complex subunit 15 isoform X1. (141 aa) |
| | Anapc11 | Anaphase-promoting complex subunit 11. (47 aa) |
| | Eed | Polycomb protein EED. (361 aa) |
| | Tlx2 | T-cell leukemia homeobox protein 2. (284 aa) |
| | Cabin1 | Calcineurin-binding protein cabin-1. (2101 aa) |
| | H1f3 | Histone H1.3. (220 aa) |
| | Cdkn1b | Cyclin-dependent kinase inhibitor 1B. (198 aa) |
| | H1f4 | Histone H1.4. (219 aa) |
| | Anapc1 | Anaphase-promoting complex subunit 1. (1666 aa) |
| | H1f6 | Histone H1t. (208 aa) |
| | Ccna2 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. (421 aa) |
| | H1f2 | Histone H1.2. (211 aa) |
| | Anapc5 | Anaphase-promoting complex subunit 5. (84 aa) |
| | H1f1 | Histone H1.1. (213 aa) |
| | Map3k5 | Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1381 aa) |
| | Cdkn1c | Cyclin-dependent kinase inhibitor 1C isoform X2. (348 aa) |
| | Rps6ka1 | Ribosomal protein S6 kinase. (743 aa) |
| | ENSMAUP00000019554 | annotation not available (231 aa) |
| | ENSMAUP00000019431 | annotation not available (150 aa) |
| | ENSMAUP00000019419 | annotation not available (406 aa) |
| | Nptx2 | Neuronal pentraxin-2. (432 aa) |
| | LOC101839356 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Fam89a | Protein FAM89A. (183 aa) |
| | Map3k6 | Mitogen-activated protein kinase kinase kinase 6 isoform X1. (1289 aa) |
| | Mapk9 | Mitogen-activated protein kinase. (423 aa) |
| | Mapk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa) |
| | Mapk10 | Mitogen-activated protein kinase 10. (252 aa) |
| | Hmga2 | High mobility group protein HMGI-C isoform X1. (108 aa) |
| | Nme8 | Thioredoxin domain-containing protein 3 isoform X1. (586 aa) |
| | Mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (203 aa) |
| | LOC101837857 | Cell division cycle protein 27 homolog. (204 aa) |
| | Tnrc6b | Trinucleotide repeat-containing gene 6B protein. (1805 aa) |
| | Kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (515 aa) |
| | Mapk14 | Mitogen-activated protein kinase. (360 aa) |
| | Anapc4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (812 aa) |
| | Fosl2 | Fos-related antigen 2. (324 aa) |
| | ENSMAUP00000016593 | annotation not available (188 aa) |
| | Tlx1 | T-cell leukemia homeobox protein 1 isoform X2. (333 aa) |
| | Fam89b | Protein FAM89B. (189 aa) |
| | Rps6ka3 | Ribosomal protein S6 kinase. (740 aa) |
| | Ube2e1 | Ubiquitin-conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa) |
| | Tm7sf3 | Transmembrane 7 superfamily member 3. (493 aa) |
| | Anapc10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | Mapkapk5 | MAP kinase-activated protein kinase 5. (392 aa) |
| | Ep400 | E1A-binding protein p400 isoform X9. (3062 aa) |
| | Asf1a | Histone chaperone ASF1A. (204 aa) |
| | Cdk3 | Cyclin-dependent kinase 3 isoform X2; Belongs to the protein kinase superfamily. (297 aa) |
| | Rbbp4 | RB binding protein 4, chromatin remodeling factor. (391 aa) |
| | Mov10 | Putative helicase MOV-10 isoform X1. (1077 aa) |
| | Hira | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1016 aa) |
| | Barhl2 | barH-like 2 homeobox protein. (388 aa) |
| | Ube2s | Ubiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (221 aa) |
| | Cdc27 | Cell division cycle protein 27 homolog. (680 aa) |
| | Nkx1-1 | NK1 transcription factor-related protein 1. (409 aa) |
| | Ccna1 | cyclin-A1; Belongs to the cyclin family. (421 aa) |
| | Kdm6b | Lysine-specific demethylase 6B isoform X4. (1652 aa) |
| | Mapk7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa) |
| | Cbx2 | Chromobox protein homolog 2. (518 aa) |
| | ENSMAUP00000012323 | annotation not available (353 aa) |
| | Hmga1 | High mobility group protein HMG-I/HMG-Y isoform X1. (96 aa) |
| | Mapk3 | Mitogen-activated protein kinase. (380 aa) |
| | Ets2 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. (470 aa) |
| | Dbx1 | Homeobox protein DBX1. (335 aa) |
| | Atm | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3014 aa) |
| | Ccne2 | G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa) |
| | Anapc2 | Anaphase-promoting complex subunit 2; Belongs to the cullin family. (833 aa) |
| | Barx2 | Homeobox protein BarH-like 2. (279 aa) |
| | Pwwp2a | PWWP domain-containing protein 2A isoform X1. (653 aa) |
| | Phc2 | Polyhomeotic-like protein 2 isoform X1. (323 aa) |
| | Rad50 | DNA repair protein RAD50. (1312 aa) |
| | Cdk4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | Lmnb1 | lamin-B1; Belongs to the intermediate filament family. (517 aa) |
| | Srcap-2 | Helicase SRCAP. (222 aa) |
| | Anapc16 | Anaphase-promoting complex subunit 16. (94 aa) |
| | Map4k4 | Mitogen-activated protein kinase kinase kinase kinase 4 isoform X13. (1289 aa) |
| | LOC101842493 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (236 aa) |
| | ENSMAUP00000007717 | annotation not available (351 aa) |
| | Srcap | Snf2 related CREBBP activator protein. (153 aa) |
| | Rbbp7 | Histone-binding protein RBBP7. (425 aa) |
| | ENSMAUP00000007258 | annotation not available (117 aa) |
| | Ezh2 | Histone-lysine N-methyltransferase EZH2 isoform X2. (745 aa) |
| | Erf | ETS domain-containing transcription factor ERF. (555 aa) |
| | LOC101823019 | Ubiquitin-like. (114 aa) |
| | ENSMAUP00000005944 | annotation not available (404 aa) |
| | Ezh1 | Histone-lysine N-methyltransferase EZH1. (747 aa) |
| | Rps27a | ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | Txndc8 | Thioredoxin domain-containing protein 8. (152 aa) |
| | Ets1 | Protein C-ets-1 isoform X2. (441 aa) |
| | Nptx1 | Neuronal pentraxin-1. (432 aa) |
| | ENSMAUP00000005256 | annotation not available (73 aa) |
| | Jun | Transcription factor AP-1; Belongs to the bZIP family. (338 aa) |
| | Mapk8 | Mitogen-activated protein kinase. (427 aa) |
| | Map3k15 | Mitogen-activated protein kinase kinase kinase 15. (1197 aa) |
| | Mapkapk2 | MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (386 aa) |
| | ENSMAUP00000004398 | annotation not available (164 aa) |
| | Mapkapk3 | MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa) |
| | Ube2c | Ubiquitin-conjugating enzyme E2C. (135 aa) |
| | Nkx1-2 | NK1 transcription factor-related protein 2. (304 aa) |
| | LOC106023108 | Polyhomeotic-like protein 1. (41 aa) |
| | Ehmt1 | Histone-lysine N-methyltransferase EHMT1 isoform X1. (1294 aa) |
| | Txn1 | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | Nrk | Nik-related protein kinase. (357 aa) |
| | Map2k7 | Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (520 aa) |
| | ENSMAUP00000000159 | annotation not available (96 aa) |
| | Tlx3 | T-cell leukemia homeobox protein 3. (291 aa) |
| | Barx1 | Homeobox protein BarH-like 1. (254 aa) |
| | Barhl1 | barH-like 1 homeobox protein. (327 aa) |
| | Fzr1 | Fizzy-related protein homolog. (493 aa) |
| | ENSMAUP00000001261 | annotation not available (61 aa) |
| | Cdkn1a | Cyclin-dependent kinase inhibitor 1. (163 aa) |
| | Cdkn2d | Cyclin-dependent kinase 4 inhibitor D. (166 aa) |
| | Cdc16 | Cell division cycle protein 16 homolog isoform X1. (620 aa) |
| | Id1 | DNA-binding protein inhibitor ID-1 isoform X2. (151 aa) |
| | Suz12 | Polycomb protein SUZ12. (726 aa) |
| | ENSMAUP00000002256 | annotation not available (75 aa) |
| | Etv3 | ETS translocation variant 3 isoform X3. (513 aa) |
| | Rps6ka2 | Ribosomal protein S6 kinase. (733 aa) |
| | Kxd1 | ubiquitin-60S ribosomal protein L40. (232 aa) |
| | Ccne1 | G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa) |
