STRINGSTRING
Mapk3 Mapk3 Cdkn2a Cdkn2a Mapk1 Mapk1 ENSMAUP00000019431 ENSMAUP00000019431 ENSMAUP00000019554 ENSMAUP00000019554 Cdkn2c Cdkn2c Cdkn2b Cdkn2b Ets1 Ets1 Rps27a Rps27a LOC101823019 LOC101823019 Erf Erf ENSMAUP00000007258 ENSMAUP00000007258 LOC101842493 LOC101842493 Cdk4 Cdk4 Ets2 Ets2 Kxd1 Kxd1 Mov10 Mov10 ENSMAUP00000022314 ENSMAUP00000022314 Gm4881 Gm4881 Cdk6 Cdk6 MDM2 MDM2 Tp53 Tp53 Tnrc6b Tnrc6b ENSMAUP00000016593 ENSMAUP00000016593 Cdkn2d Cdkn2d Id1 Id1 Etv3 Etv3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mapk3Mitogen-activated protein kinase. (380 aa)
Cdkn2aCyclin-dependent kinase inhibitor 2A. (157 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
ENSMAUP00000019431annotation not available (150 aa)
ENSMAUP00000019554annotation not available (231 aa)
Cdkn2cCyclin-dependent kinase 4 inhibitor C. (168 aa)
Cdkn2bCyclin-dependent kinase 4 inhibitor B isoform X1. (130 aa)
Ets1Protein C-ets-1 isoform X2. (441 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
LOC101823019Ubiquitin-like. (114 aa)
ErfETS domain-containing transcription factor ERF. (555 aa)
ENSMAUP00000007258annotation not available (117 aa)
LOC101842493Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (236 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Ets2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (470 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
Mov10Putative helicase MOV-10 isoform X1. (1077 aa)
ENSMAUP00000022314annotation not available (101 aa)
Gm4881Uncharacterized protein LOC101827640. (353 aa)
Cdk6Cyclin-dependent kinase 6. (203 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
Tnrc6bTrinucleotide repeat-containing gene 6B protein. (1805 aa)
ENSMAUP00000016593annotation not available (188 aa)
Cdkn2dCyclin-dependent kinase 4 inhibitor D. (166 aa)
Id1DNA-binding protein inhibitor ID-1 isoform X2. (151 aa)
Etv3ETS translocation variant 3 isoform X3. (513 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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