(33 nodes) Platelet calcium homeostasis network (Mesocricetus auratus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	Atp2a3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1038 aa)
	LOC101824962	Short transient receptor potential channel 2; Belongs to the transient receptor (TC 1.A.4) family. (433 aa)
	P2rx6	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (379 aa)
	Atp2b4	ATPase plasma membrane Ca2+ transporting 4. (1038 aa)
	Trpc7	Short transient receptor potential channel 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
	Orai2	Protein orai-2. (250 aa)
	Reep3	Receptor expression-enhancing protein. (258 aa)
	Calm1	Calmodulin 1. (149 aa)
	P2rx4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (151 aa)
	Xndc1	Short transient receptor potential channel 2-like. (390 aa)
	Atp2a2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (966 aa)
	Reep2	Receptor expression-enhancing protein. (250 aa)
	Itpr3	Inositol 1,4,5-trisphosphate receptor type 3. (2660 aa)
	Calm2	Calmodulin 2. (149 aa)
	Itpr1	Inositol 1,4,5-trisphosphate receptor type 1 isoform X2. (2757 aa)
	Orai1	Calcium release-activated calcium channel protein 1. (302 aa)
	Trpc6	Short transient receptor potential channel 6; Belongs to the transient receptor (TC 1.A.4) family. (928 aa)
	P2rx3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
	Slc8a1	Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
	Itpr2	Inositol 1,4,5-trisphosphate receptor type 2. (2584 aa)
	Slc8a3	Sodium/calcium exchanger 3 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
	P2rx2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (414 aa)
	Atp2a1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (980 aa)
	Calm3	Calmodulin-2 isoform X1; Belongs to the calmodulin family. (149 aa)
	Slc8a2	Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
	P2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
	Atp2b3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1203 aa)
	Sri	Sorcin isoform X2. (198 aa)
	Orai3	Protein orai-3. (290 aa)
	Atp2b2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
	P2rx5	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (205 aa)
	Reep4	Receptor expression-enhancing protein. (257 aa)
	Atp2b1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)

Your Current Organism:

Mesocricetus auratus

NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atp2a1	Atp2a2	ENSMAUP00000010852	ENSMAUP00000024591	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.854
Atp2a1	Atp2a3	ENSMAUP00000010852	ENSMAUP00000004603	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.858
Atp2a1	Atp2b1	ENSMAUP00000010852	ENSMAUP00000007771	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.718
Atp2a1	Atp2b2	ENSMAUP00000010852	ENSMAUP00000007912	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.703
Atp2a1	Atp2b3	ENSMAUP00000010852	ENSMAUP00000008658	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.704
Atp2a1	Atp2b4	ENSMAUP00000010852	ENSMAUP00000005560	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	ATPase plasma membrane Ca2+ transporting 4.	0.712
Atp2a1	Itpr1	ENSMAUP00000010852	ENSMAUP00000018380	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Inositol 1,4,5-trisphosphate receptor type 1 isoform X2.	0.436
Atp2a1	Itpr2	ENSMAUP00000010852	ENSMAUP00000012665	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Inositol 1,4,5-trisphosphate receptor type 2.	0.437
Atp2a1	Itpr3	ENSMAUP00000010852	ENSMAUP00000022656	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Inositol 1,4,5-trisphosphate receptor type 3.	0.436
Atp2a2	Atp2a1	ENSMAUP00000024591	ENSMAUP00000010852	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.854
Atp2a2	Atp2a3	ENSMAUP00000024591	ENSMAUP00000004603	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.859
Atp2a2	Atp2b1	ENSMAUP00000024591	ENSMAUP00000007771	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.721
Atp2a2	Atp2b2	ENSMAUP00000024591	ENSMAUP00000007912	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.718
Atp2a2	Atp2b3	ENSMAUP00000024591	ENSMAUP00000008658	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.705
Atp2a2	Atp2b4	ENSMAUP00000024591	ENSMAUP00000005560	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	ATPase plasma membrane Ca2+ transporting 4.	0.716
Atp2a2	Itpr1	ENSMAUP00000024591	ENSMAUP00000018380	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Inositol 1,4,5-trisphosphate receptor type 1 isoform X2.	0.618
Atp2a2	Itpr2	ENSMAUP00000024591	ENSMAUP00000012665	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Inositol 1,4,5-trisphosphate receptor type 2.	0.510
Atp2a2	Itpr3	ENSMAUP00000024591	ENSMAUP00000022656	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Inositol 1,4,5-trisphosphate receptor type 3.	0.595
Atp2a2	Slc8a1	ENSMAUP00000024591	ENSMAUP00000014201	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.521
Atp2a3	Atp2a1	ENSMAUP00000004603	ENSMAUP00000010852	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.858

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