STRINGSTRING
Grb2 Grb2 Pik3r2 Pik3r2 Crkl Crkl Ptpn11 Ptpn11 ENSMAUP00000013047 ENSMAUP00000013047 Rapgef1 Rapgef1 LOC110339561 LOC110339561 Il2rg Il2rg Jak3 Jak3 Jak1 Jak1 Il5 Il5 Gab1 Gab1 Csf2 Csf2 ENSMAUP00000007258 ENSMAUP00000007258 Jak2 Jak2 LOC101823019 LOC101823019 Gab2 Gab2 Pik3r1 Pik3r1 Fyn Fyn Inpp5d Inpp5d Rps27a Rps27a Pik3cb Pik3cb LOC101842510 LOC101842510 Yes1 Yes1 Prkaca Prkaca Lyn Lyn Kxd1 Kxd1 LOC101831400 LOC101831400 Inppl1 Inppl1 ENSMAUP00000002256 ENSMAUP00000002256 Ywhaz Ywhaz LOC101835654 LOC101835654 Pik3cd Pik3cd ENSMAUP00000000785 ENSMAUP00000000785 Sos1 Sos1 Cbl Cbl Vav1 Vav1 Pik3r2-2 Pik3r2-2 Il5ra Il5ra Crk Crk Il2ra Il2ra Shc1 Shc1 Pik3ca Pik3ca ENSMAUP00000022314 ENSMAUP00000022314 Syk Syk Il2rb Il2rb ENSMAUP00000019431 ENSMAUP00000019431 Il2 Il2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Grb2Growth factor receptor-bound protein 2. (217 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
CrklCrk-like protein. (303 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ENSMAUP00000013047annotation not available (67 aa)
Rapgef1Rap guanine nucleotide exchange factor 1. (1202 aa)
LOC110339561Signal transducer and activator of transcription 5B-like. (125 aa)
Il2rgCytokine receptor common subunit gamma isoform X1. (363 aa)
Jak3Tyrosine-protein kinase. (1080 aa)
Jak1Tyrosine-protein kinase. (1161 aa)
Il5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (121 aa)
Gab1GRB2-associated-binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. (665 aa)
Csf2Granulocyte-macrophage colony-stimulating factor. (142 aa)
ENSMAUP00000007258annotation not available (117 aa)
Jak2Tyrosine-protein kinase. (1132 aa)
LOC101823019Ubiquitin-like. (114 aa)
Gab2GRB2-associated-binding protein 2 isoform X1. (672 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
FynTyrosine-protein kinase. (537 aa)
Inpp5dPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1153 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC101842510Signal transducer and activator of transcription 5A. (228 aa)
Yes1Tyrosine-protein kinase. (541 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
LynTyrosine-protein kinase. (438 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
Inppl1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1. (1257 aa)
ENSMAUP00000002256annotation not available (75 aa)
Ywhaz14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (212 aa)
LOC101835654Signal transducer and activator of transcription. (228 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ENSMAUP00000000785annotation not available (661 aa)
Sos1Son of sevenless homolog 1. (1319 aa)
CblE3 ubiquitin-protein ligase CBL. (51 aa)
Vav1Proto-oncogene vav. (845 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Il5raInterleukin-5 receptor subunit alpha isoform X2. (416 aa)
CrkAdapter molecule crk isoform X1. (304 aa)
Il2raInterleukin-2 receptor subunit alpha. (267 aa)
Shc1SHC-transforming protein 1 isoform X1. (579 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSMAUP00000022314annotation not available (101 aa)
SykTyrosine-protein kinase. (629 aa)
Il2rbInterleukin-2 receptor subunit beta. (415 aa)
ENSMAUP00000019431annotation not available (150 aa)
Il2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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