STRINGSTRING
Hras Hras Src Src Ppp2ca Ppp2ca LOC101827110 LOC101827110 ENSMAUP00000007258 ENSMAUP00000007258 Fgf23 Fgf23 LOC101823019 LOC101823019 Pik3r1 Pik3r1 Rps27a Rps27a Eras Eras Ppp2r1a Ppp2r1a Kxd1 Kxd1 ENSMAUP00000002256 ENSMAUP00000002256 Fndc3b Fndc3b Mknk1 Mknk1 Plcg1 Plcg1 Fgf18 Fgf18 Spry2 Spry2 Sos1 Sos1 Nras Nras Shc1 Shc1 Mknk2 Mknk2 Fgf20 Fgf20 Fndc3a Fndc3a Fgfr4 Fgfr4 Fgf1 Fgf1 Pik3ca Pik3ca ENSMAUP00000022314 ENSMAUP00000022314 Fgf9 Fgf9 ENSMAUP00000021418 ENSMAUP00000021418 Ppp2cb Ppp2cb Mapk3 Mapk3 Fgf4 Fgf4 Fgf19 Fgf19 Fgf16 Fgf16 Frs2 Frs2 ENSMAUP00000019431 ENSMAUP00000019431 Kras Kras Mapk1 Mapk1 Grb2 Grb2 Fgf8 Fgf8 Braf Braf Fgf17 Fgf17 Fgf2 Fgf2 Frs3 Frs3 Klb Klb Csde1 Csde1 Ptpn11 Ptpn11 Cbl Cbl Fgf6 Fgf6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
SrcTyrosine-protein kinase. (536 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
LOC101827110Fibronectin type III domain containing protein 3C1-like. (1355 aa)
ENSMAUP00000007258annotation not available (117 aa)
Fgf23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
LOC101823019Ubiquitin-like. (114 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
ErasGTPase ERas. (228 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
ENSMAUP00000002256annotation not available (75 aa)
Fndc3bFibronectin type III domain-containing protein 3B isoform X1. (1206 aa)
Mknk1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (415 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1293 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Spry2Protein sprouty homolog 2. (320 aa)
Sos1Son of sevenless homolog 1. (1319 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
Shc1SHC-transforming protein 1 isoform X1. (579 aa)
Mknk2MAP kinase-interacting serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (459 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
Fndc3aFibronectin type-III domain-containing protein 3A. (1171 aa)
Fgfr4Fibroblast growth factor receptor. (794 aa)
Fgf1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (155 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSMAUP00000022314annotation not available (101 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSMAUP00000021418annotation not available (290 aa)
Ppp2cbProtein phosphatase 2 catalytic subunit beta. (299 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
Fgf19Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (215 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Frs2Fibroblast growth factor receptor substrate 2. (510 aa)
ENSMAUP00000019431annotation not available (150 aa)
KrasGTPase KRas isoform X3. (189 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
BrafSerine/threonine-protein kinase B-raf. (710 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Frs3Fibroblast growth factor receptor substrate 3. (495 aa)
KlbLOW QUALITY PROTEIN: beta-klotho. (1043 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
CblE3 ubiquitin-protein ligase CBL. (51 aa)
Fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.