STRINGSTRING
Pole2 Pole2 Rev1 Rev1 ENSMAUP00000022826 ENSMAUP00000022826 Trim65 Trim65 Uba7 Uba7 Meiob Meiob ENSMAUP00000002060 ENSMAUP00000002060 ENSMAUP00000001221 ENSMAUP00000001221 Rpa3 Rpa3 Pole3 Pole3 ENSMAUP00000022314 ENSMAUP00000022314 Atad5 Atad5 Rcbtb1 Rcbtb1 Pole Pole ENSMAUP00000019431 ENSMAUP00000019431 Trim47 Trim47 Pclaf Pclaf Polk Polk Rfc3 Rfc3 Pold4 Pold4 Usp43 Usp43 Rfc1 Rfc1 Pold3 Pold3 Usp31 Usp31 Rcbtb2 Rcbtb2 Poli Poli Pcna Pcna Rpa1 Rpa1 Polh Polh Isg15 Isg15 ENSMAUP00000007258 ENSMAUP00000007258 ENSMAUP00000006950 ENSMAUP00000006950 LOC101823019 LOC101823019 Pold2 Pold2 Rps27a Rps27a Trim25 Trim25 Rfc4 Rfc4 Pold1 Pold1 Rpa2 Rpa2 Kxd1 Kxd1 Pole4 Pole4 ENSMAUP00000002256 ENSMAUP00000002256 Usp10 Usp10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (461 aa)
Rev1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (750 aa)
ENSMAUP00000022826annotation not available (193 aa)
Trim65Tripartite motif-containing protein 65. (519 aa)
Uba7Ubiquitin-like modifier-activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (968 aa)
MeiobMeiosis-specific with OB domain-containing protein isoform X1. (470 aa)
ENSMAUP00000002060annotation not available (103 aa)
ENSMAUP00000001221annotation not available (406 aa)
Rpa3Replication protein A 14 kDa subunit. (121 aa)
Pole3DNA polymerase epsilon subunit 3. (146 aa)
ENSMAUP00000022314annotation not available (101 aa)
Atad5ATPase family AAA domain-containing protein 5. (1819 aa)
Rcbtb1RCC1 and BTB domain-containing protein 1 isoform X2. (531 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (663 aa)
ENSMAUP00000019431annotation not available (150 aa)
Trim47Tripartite motif-containing protein 47. (641 aa)
PclafPCNA-associated factor. (97 aa)
PolkDNA polymerase kappa. (856 aa)
Rfc3Replication factor C subunit 3. (356 aa)
Pold4DNA polymerase delta subunit 4. (74 aa)
Usp43Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family. (971 aa)
Rfc1Replication factor C subunit 1. (1063 aa)
Pold3DNA polymerase delta subunit 3 isoform X1. (462 aa)
Usp31Ubiquitin carboxyl-terminal hydrolase 31; Belongs to the peptidase C19 family. (1175 aa)
Rcbtb2RCC1 and BTB domain-containing protein 2 isoform X4. (551 aa)
PoliDNA polymerase iota isoform X1. (734 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa)
PolhDNA polymerase eta isoform X1. (695 aa)
Isg15Ubiquitin-like protein ISG15. (160 aa)
ENSMAUP00000007258annotation not available (117 aa)
ENSMAUP00000006950annotation not available (259 aa)
LOC101823019Ubiquitin-like. (114 aa)
Pold2DNA polymerase delta subunit 2 isoform X2. (260 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
Trim25E3 ubiquitin/ISG15 ligase TRIM25. (602 aa)
Rfc4Replication factor C subunit 4. (362 aa)
Pold1DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] (1101 aa)
Rpa2Replication protein A 32 kDa subunit. (270 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
Pole4DNA polymerase epsilon subunit 4. (124 aa)
ENSMAUP00000002256annotation not available (75 aa)
Usp10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (114 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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