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| | Uimc1 | BRCA1-A complex subunit RAP80. (726 aa) |
| | Slx1a | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (269 aa) |
| | Rad50 | DNA repair protein RAD50. (1312 aa) |
| | Rad51ap1 | RAD51-associated protein 1 isoform X1. (332 aa) |
| | ENSMAUP00000009408 | annotation not available (808 aa) |
| | H2bu2 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa) |
| | Ppp4c | Serine/threonine-protein phosphatase. (307 aa) |
| | Parp3 | Poly [ADP-ribose] polymerase. (531 aa) |
| | ENSMAUP00000008754 | annotation not available (103 aa) |
| | Babam2 | BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] (360 aa) |
| | H2ax | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | Polh | DNA polymerase eta isoform X1. (695 aa) |
| | Rad51d | DNA repair protein RAD51 homolog 4 isoform X2. (328 aa) |
| | Blm | Bloom syndrome protein. (1415 aa) |
| | Eme2 | Probable crossover junction endonuclease EME2. (376 aa) |
| | ENSMAUP00000007258 | annotation not available (117 aa) |
| | ENSMAUP00000006950 | annotation not available (259 aa) |
| | Recql4 | ATP-dependent DNA helicase Q4. (1206 aa) |
| | ENSMAUP00000006643 | annotation not available (1305 aa) |
| | LOC101823019 | Ubiquitin-like. (114 aa) |
| | Pold2 | DNA polymerase delta subunit 2 isoform X2. (260 aa) |
| | Parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa) |
| | Rbbp8 | DNA endonuclease RBBP8 isoform X1. (813 aa) |
| | Rps27a | ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | LOC101824940 | Flap endonuclease GEN homolog 1-like. (487 aa) |
| | LOC101825928 | Histone H4. (103 aa) |
| | Ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. (146 aa) |
| | Babam1 | BRISC and BRCA1-A complex member 1. (287 aa) |
| | LOC101843803 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Bard1 | BRCA1-associated RING domain protein 1 isoform X1. (767 aa) |
| | Rad51b | DNA repair protein RAD51 homolog 2 isoform X2. (258 aa) |
| | LOC101843531 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | Rfc4 | Replication factor C subunit 4. (362 aa) |
| | Abraxas1 | BRCA1-A complex subunit Abraxas isoform X1. (404 aa) |
| | Pold1 | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] (1101 aa) |
| | Ube2n | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | Ankrd12 | Ankyrin repeat domain-containing protein 12. (1960 aa) |
| | Rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (488 aa) |
| | Dna2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1005 aa) |
| | Rpa2 | Replication protein A 32 kDa subunit. (270 aa) |
| | Kxd1 | ubiquitin-60S ribosomal protein L40. (232 aa) |
| | Tp53bp1 | TP53-binding protein 1 isoform X2. (716 aa) |
| | Pole4 | DNA polymerase epsilon subunit 4. (124 aa) |
| | ENSMAUP00000002256 | annotation not available (75 aa) |
| | Rad17 | Cell cycle checkpoint protein RAD17 isoform X1. (701 aa) |
| | ENSMAUP00000002060 | annotation not available (103 aa) |
| | H2bc1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | Pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (461 aa) |
| | ENSMAUP00000001221 | annotation not available (406 aa) |
| | Rpa3 | Replication protein A 14 kDa subunit. (121 aa) |
| | Pole3 | DNA polymerase epsilon subunit 3. (146 aa) |
| | Rmi2 | recQ-mediated genome instability protein 2 isoform X2. (147 aa) |
| | Rad51c | DNA repair protein RAD51 homolog 3 isoform X1. (365 aa) |
| | Xrcc1 | DNA repair protein XRCC1. (628 aa) |
| | Rad1 | Cell cycle checkpoint protein RAD1 isoform X1. (280 aa) |
| | ENSMAUP00000022826 | annotation not available (193 aa) |
| | Lig3 | DNA ligase. (1003 aa) |
| | Brca2 | LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (1176 aa) |
| | ENSMAUP00000022314 | annotation not available (101 aa) |
| | Rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (187 aa) |
| | Rad9b | Cell cycle checkpoint control protein RAD9B. (267 aa) |
| | Rcbtb1 | RCC1 and BTB domain-containing protein 1 isoform X2. (531 aa) |
| | Cdk2 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa) |
| | Atrip | ATR-interacting protein isoform X1. (769 aa) |
| | Ube2i | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451 (By similarity). Can catalyze the formation of poly-SUMO chains (By similarity). Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386' (By similarity). Mediates sumoylation of ERCC6 which is essential for its transcription-coupled [...] (158 aa) |
| | Brip1 | LOW QUALITY PROTEIN: Fanconi anemia group J protein. (1161 aa) |
| | Pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (663 aa) |
| | ENSMAUP00000020431 | annotation not available (107 aa) |
| | Pold4 | DNA polymerase delta subunit 4. (74 aa) |
| | Kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (515 aa) |
| | Parp2 | Poly [ADP-ribose] polymerase. (561 aa) |
| | Wrn | Werner syndrome ATP-dependent helicase isoform X1. (1400 aa) |
| | Mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (203 aa) |
| | ENSMAUP00000020353 | annotation not available (103 aa) |
| | LOC101830217 | Histone H2B type 1. (126 aa) |
| | Ercc4 | DNA repair endonuclease XPF. (913 aa) |
| | ENSMAUP00000020273 | annotation not available (126 aa) |
| | ENSMAUP00000020205 | annotation not available (103 aa) |
| | Ccna2 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. (421 aa) |
| | Sirt7 | NAD-dependent protein deacetylase sirtuin-7. (402 aa) |
| | LOC106022595 | Histone H4. (103 aa) |
| | ENSMAUP00000019431 | annotation not available (150 aa) |
| | LOC101841682 | Histone H2B type 1. (126 aa) |
| | LOC101839356 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101844254 | Histone H2B type 1. (126 aa) |
| | LOC101840877 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC106022591 | Histone H4. (103 aa) |
| | Exo1 | Exonuclease 1 isoform X1. (191 aa) |
| | Rad52 | DNA repair protein RAD52 homolog isoform X3. (418 aa) |
| | Hus1 | Checkpoint protein; Belongs to the HUS1 family. (281 aa) |
| | Brcc3 | Lys-63-specific deubiquitinase BRCC36 isoform X1. (291 aa) |
| | Rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | Clspn | Claspin isoform X2. (1286 aa) |
| | Polk | DNA polymerase kappa. (856 aa) |
| | Eme1 | Crossover junction endonuclease EME1 isoform X1. (568 aa) |
| | LOC101829406 | Histone H4. (103 aa) |
| | Atm | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3014 aa) |
| | Fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | Tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa) |
| | Xrcc2 | DNA repair protein XRCC2 isoform X1. (41 aa) |
| | Tdrd3 | Tudor domain-containing protein 3 isoform X1. (745 aa) |
| | Slf1 | SMC5-SMC6 complex localization factor protein 1 isoform X1. (1061 aa) |
| | Pias4 | E3 SUMO-protein ligase PIAS4 isoform X2. (508 aa) |
| | Chek1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa) |
| | Topbp1 | DNA topoisomerase 2-binding protein 1. (1473 aa) |
| | Ccna1 | cyclin-A1; Belongs to the cyclin family. (421 aa) |
| | ENSMAUP00000012929 | annotation not available (90 aa) |
| | Palb2 | Partner and localizer of BRCA2. (354 aa) |
| | Rcbtb2 | RCC1 and BTB domain-containing protein 2 isoform X4. (551 aa) |
| | Atr | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2148 aa) |
| | Herc2 | E3 ubiquitin-protein ligase HERC2. (4675 aa) |
| | Rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (537 aa) |
| | Spidr | DNA repair-scaffolding protein isoform X1. (737 aa) |
| | Cdk3 | Cyclin-dependent kinase 3 isoform X2; Belongs to the protein kinase superfamily. (297 aa) |
| | Rnf169 | E3 ubiquitin-protein ligase RNF169. (694 aa) |
| | Pold3 | DNA polymerase delta subunit 3 isoform X1. (462 aa) |
| | Ercc1 | DNA excision repair protein ERCC-1. (297 aa) |
| | Polq | DNA polymerase theta. (163 aa) |
| | LOC101830315 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (50 aa) |
| | Mus81 | Crossover junction endonuclease MUS81. (430 aa) |
| | Rfc1 | Replication factor C subunit 1. (1063 aa) |
| | Nsd2 | Histone-lysine N-methyltransferase NSD2. (1367 aa) |
| | LOC106023000 | DNA endonuclease RBBP8-like. (75 aa) |
| | Rfc3 | Replication factor C subunit 3. (356 aa) |
| | Xrcc3 | DNA repair protein XRCC3 isoform X3. (349 aa) |
| | Exd2 | Exonuclease 3'-5' domain-containing protein 2. (175 aa) |
| | Sirt6 | NAD-dependent protein deacetylase sirtuin-6 isoform X1. (334 aa) |
| | Nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (556 aa) |
| | Meiob | Meiosis-specific with OB domain-containing protein isoform X1. (470 aa) |
| | Slx4 | Structure-specific endonuclease subunit SLX4 isoform X3. (261 aa) |
| | Pwwp2a | PWWP domain-containing protein 2A isoform X1. (653 aa) |
| | Pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | LOC101829234 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Ppp4r2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2. (365 aa) |
| | Timeless | Protein timeless homolog. (521 aa) |
