STRINGSTRING
Pias4 Pias4 ENSMAUP00000020353 ENSMAUP00000020353 LOC101830217 LOC101830217 ENSMAUP00000020273 ENSMAUP00000020273 ENSMAUP00000020205 ENSMAUP00000020205 LOC106022595 LOC106022595 Uimc1 Uimc1 Rad50 Rad50 H2bu2 H2bu2 ENSMAUP00000008754 ENSMAUP00000008754 Babam2 Babam2 Chek2 Chek2 H2ax H2ax ENSMAUP00000007258 ENSMAUP00000007258 Apbb2 Apbb2 ENSMAUP00000006643 ENSMAUP00000006643 LOC101823019 LOC101823019 Kpna2 Kpna2 Rps27a Rps27a LOC101825928 LOC101825928 Ube2v2 Ube2v2 Babam1 Babam1 LOC101843803 LOC101843803 Bard1 Bard1 LOC101843531 LOC101843531 Abraxas1 Abraxas1 Ube2n Ube2n Ankrd12 Ankrd12 Rnf8 Rnf8 Kxd1 Kxd1 Tp53bp1 Tp53bp1 ENSMAUP00000002256 ENSMAUP00000002256 H2bc1 H2bc1 Apbb1 Apbb1 ENSMAUP00000019431 ENSMAUP00000019431 Tp53 Tp53 Kdm4b Kdm4b Nbn Nbn Eya1 Eya1 Eya4 Eya4 Eya2 Eya2 ENSMAUP00000022314 ENSMAUP00000022314 Ube2i Ube2i ENSMAUP00000020431 ENSMAUP00000020431 LOC101841682 LOC101841682 LOC101839356 LOC101839356 LOC101844254 LOC101844254 LOC101840877 LOC101840877 LOC106022591 LOC106022591 Brcc3 Brcc3 Mre11 Mre11 Kat5 Kat5 Nsd2 Nsd2 Eya3 Eya3 Ppp5c Ppp5c Rnf169 Rnf169 Rnf168 Rnf168 Herc2 Herc2 Bap1 Bap1 ENSMAUP00000012929 ENSMAUP00000012929 Ubxn1 Ubxn1 LOC101829234 LOC101829234 Pwwp2a Pwwp2a LOC101829406 LOC101829406 Atm Atm Kdm4a Kdm4a Baz1a Baz1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pias4E3 SUMO-protein ligase PIAS4 isoform X2. (508 aa)
ENSMAUP00000020353annotation not available (103 aa)
LOC101830217Histone H2B type 1. (126 aa)
ENSMAUP00000020273annotation not available (126 aa)
ENSMAUP00000020205annotation not available (103 aa)
LOC106022595Histone H4. (103 aa)
Uimc1BRCA1-A complex subunit RAP80. (726 aa)
Rad50DNA repair protein RAD50. (1312 aa)
H2bu2Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMAUP00000008754annotation not available (103 aa)
Babam2BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] (360 aa)
Chek2Serine/threonine-protein kinase Chk2. (539 aa)
H2axHistone H2A; Belongs to the histone H2A family. (143 aa)
ENSMAUP00000007258annotation not available (117 aa)
Apbb2Amyloid beta A4 precursor protein-binding family B member 2 isoform X2. (760 aa)
ENSMAUP00000006643annotation not available (1305 aa)
LOC101823019Ubiquitin-like. (114 aa)
Kpna2Importin subunit alpha; Functions in nuclear protein import. (72 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
LOC101825928Histone H4. (103 aa)
Ube2v2Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. (146 aa)
Babam1BRISC and BRCA1-A complex member 1. (287 aa)
LOC101843803Histone H2B; Belongs to the histone H2B family. (126 aa)
Bard1BRCA1-associated RING domain protein 1 isoform X1. (767 aa)
LOC101843531Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
Abraxas1BRCA1-A complex subunit Abraxas isoform X1. (404 aa)
Ube2nUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
Ankrd12Ankyrin repeat domain-containing protein 12. (1960 aa)
Rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (488 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
Tp53bp1TP53-binding protein 1 isoform X2. (716 aa)
ENSMAUP00000002256annotation not available (75 aa)
H2bc1Histone H2B; Belongs to the histone H2B family. (127 aa)
Apbb1Amyloid beta A4 precursor protein-binding family B member 1 isoform X1. (710 aa)
ENSMAUP00000019431annotation not available (150 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
Kdm4bLysine-specific demethylase 4B. (1040 aa)
NbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (556 aa)
Eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
Eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (550 aa)
Eya2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (529 aa)
ENSMAUP00000022314annotation not available (101 aa)
Ube2iSUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451 (By similarity). Can catalyze the formation of poly-SUMO chains (By similarity). Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386' (By similarity). Mediates sumoylation of ERCC6 which is essential for its transcription-coupled [...] (158 aa)
ENSMAUP00000020431annotation not available (107 aa)
LOC101841682Histone H2B type 1. (126 aa)
LOC101839356Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101844254Histone H2B type 1. (126 aa)
LOC101840877Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC106022591Histone H4. (103 aa)
Brcc3Lys-63-specific deubiquitinase BRCC36 isoform X1. (291 aa)
Mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (203 aa)
Kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (515 aa)
Nsd2Histone-lysine N-methyltransferase NSD2. (1367 aa)
Eya3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (496 aa)
Ppp5cSerine/threonine-protein phosphatase. (499 aa)
Rnf169E3 ubiquitin-protein ligase RNF169. (694 aa)
Rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (537 aa)
Herc2E3 ubiquitin-protein ligase HERC2. (4675 aa)
Bap1Ubiquitin carboxyl-terminal hydrolase. (726 aa)
ENSMAUP00000012929annotation not available (90 aa)
Ubxn1UBX domain-containing protein 1. (297 aa)
LOC101829234Histone H2B; Belongs to the histone H2B family. (126 aa)
Pwwp2aPWWP domain-containing protein 2A isoform X1. (653 aa)
LOC101829406Histone H4. (103 aa)
AtmSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3014 aa)
Kdm4aLysine-specific demethylase 4A. (1063 aa)
Baz1aBromodomain adjacent to zinc finger domain protein 1A. (1457 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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