STRINGSTRING
Meiob Meiob Fance Fance Fancm Fancm Mus81 Mus81 Faap24 Faap24 Ercc1 Ercc1 Faap100 Faap100 Faap20 Faap20 Fancg Fancg Atr Atr Fancc Fancc Fancl Fancl Fancd2 Fancd2 Eme1 Eme1 Fan1 Fan1 Slx1a Slx1a Rpa1 Rpa1 Usp1 Usp1 LOC101829777 LOC101829777 Dclre1a Dclre1a Eme2 Eme2 ENSMAUP00000007258 ENSMAUP00000007258 Poln Poln LOC101823019 LOC101823019 Cenpx Cenpx Rps27a Rps27a Fanca Fanca Proser1 Proser1 Nutf2 Nutf2 Rpa2 Rpa2 Kxd1 Kxd1 ENSMAUP00000002256 ENSMAUP00000002256 ENSMAUP00000002060 ENSMAUP00000002060 ENSMAUP00000002009 ENSMAUP00000002009 Ube2t Ube2t Rpa3 Rpa3 Dclre1b Dclre1b Wdr48 Wdr48 ENSMAUP00000019431 ENSMAUP00000019431 Ercc4 Ercc4 Atrip Atrip Fancb Fancb LOC101831337 LOC101831337 ENSMAUP00000022314 ENSMAUP00000022314 Fanci Fanci Slx4 Slx4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MeiobMeiosis-specific with OB domain-containing protein isoform X1. (470 aa)
FanceFanconi anemia group E protein. (213 aa)
FancmFanconi anemia group M protein. (1967 aa)
Mus81Crossover junction endonuclease MUS81. (430 aa)
Faap24Fanconi anemia core complex-associated protein 24. (223 aa)
Ercc1DNA excision repair protein ERCC-1. (297 aa)
Faap100Fanconi anemia core complex-associated protein 100. (884 aa)
Faap20Fanconi anemia core complex-associated protein 20. (187 aa)
FancgFanconi anemia group G protein isoform X1. (621 aa)
AtrSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2148 aa)
FanccFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (584 aa)
FanclE3 ubiquitin-protein ligase FANCL isoform X1. (375 aa)
Fancd2Fanconi anemia group D2 protein. (1385 aa)
Eme1Crossover junction endonuclease EME1 isoform X1. (568 aa)
Fan1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1018 aa)
Slx1aStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (269 aa)
Rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa)
Usp1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (783 aa)
LOC1018297775' exonuclease Apollo-like. (97 aa)
Dclre1aDNA cross-link repair 1A protein. (1028 aa)
Eme2Probable crossover junction endonuclease EME2. (376 aa)
ENSMAUP00000007258annotation not available (117 aa)
PolnLOW QUALITY PROTEIN: DNA polymerase nu. (801 aa)
LOC101823019Ubiquitin-like. (114 aa)
CenpxCentromere protein X. (78 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
FancaFanconi anemia group A protein. (1352 aa)
Proser1Proline and serine-rich protein 1. (176 aa)
Nutf2Nuclear transport factor 2. (127 aa)
Rpa2Replication protein A 32 kDa subunit. (270 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
ENSMAUP00000002256annotation not available (75 aa)
ENSMAUP00000002060annotation not available (103 aa)
ENSMAUP00000002009annotation not available (130 aa)
Ube2tUbiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (204 aa)
Rpa3Replication protein A 14 kDa subunit. (121 aa)
Dclre1b5' exonuclease Apollo-like isoform X1. (350 aa)
Wdr48WD repeat-containing protein 48 isoform X2. (678 aa)
ENSMAUP00000019431annotation not available (150 aa)
Ercc4DNA repair endonuclease XPF. (913 aa)
AtripATR-interacting protein isoform X1. (769 aa)
FancbFanconi anemia group B protein isoform X1. (843 aa)
LOC101831337Centromere protein S. (58 aa)
ENSMAUP00000022314annotation not available (101 aa)
FanciFanconi anemia group I protein. (1330 aa)
Slx4Structure-specific endonuclease subunit SLX4 isoform X3. (261 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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