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| | Taf3 | Transcription initiation factor TFIID subunit 3. (930 aa) |
| | Rpa3 | Replication protein A 14 kDa subunit. (121 aa) |
| | Rmi2 | recQ-mediated genome instability protein 2 isoform X2. (147 aa) |
| | Rad1 | Cell cycle checkpoint protein RAD1 isoform X1. (280 aa) |
| | Supt16h | FACT complex subunit SPT16. (1047 aa) |
| | Meiob | Meiosis-specific with OB domain-containing protein isoform X1. (470 aa) |
| | Nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (556 aa) |
| | Exd2 | Exonuclease 3'-5' domain-containing protein 2. (175 aa) |
| | Csnk2b | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa) |
| | Cdk5r1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | Prkab1 | 5'-AMP-activated protein kinase subunit beta-1. (270 aa) |
| | Plk3 | Serine/threonine-protein kinase PLK. (648 aa) |
| | Ccna2 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. (421 aa) |
| | ENSMAUP00000020346 | annotation not available (187 aa) |
| | Taf7l | Transcription initiation factor TFIID subunit 7-like. (369 aa) |
| | Taf1 | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (By similarity). Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4 (By similar [...] (1784 aa) |
| | Brip1 | LOW QUALITY PROTEIN: Fanconi anemia group J protein. (1161 aa) |
| | Atrip | ATR-interacting protein isoform X1. (769 aa) |
| | Cdk2 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa) |
| | Tbp | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] (300 aa) |
| | Rad9b | Cell cycle checkpoint control protein RAD9B. (267 aa) |
| | Hipk4 | Homeodomain-interacting protein kinase 4. (616 aa) |
| | ENSMAUP00000022314 | annotation not available (101 aa) |
| | Aurkb | Aurora kinase B isoform X1; Belongs to the protein kinase superfamily. (339 aa) |
| | Taf12 | Transcription initiation factor TFIID subunit 12 isoform X1. (213 aa) |
| | Tp53rk | TP53-regulating kinase. (246 aa) |
| | Csnk2a1 | LOW QUALITY PROTEIN: casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (380 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa) |
| | Tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa) |
| | Mapk11 | Mitogen-activated protein kinase. (355 aa) |
| | LOC101829505 | TATA-binding protein-associated factor 2N. (299 aa) |
| | ENSMAUP00000019554 | annotation not available (231 aa) |
| | ENSMAUP00000019431 | annotation not available (150 aa) |
| | Nuak2 | NUAK family SNF1-like kinase 2. (642 aa) |
| | Exo1 | Exonuclease 1 isoform X1. (191 aa) |
| | LOC101832350 | Aurora kinase C-like. (108 aa) |
| | Hus1 | Checkpoint protein; Belongs to the HUS1 family. (281 aa) |
| | Rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | Rfc3 | Replication factor C subunit 3. (356 aa) |
| | Cdk5 | Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | Mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (203 aa) |
| | Wrn | Werner syndrome ATP-dependent helicase isoform X1. (1400 aa) |
| | ENSMAUP00000017300 | annotation not available (1042 aa) |
| | Kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (515 aa) |
| | Mapk14 | Mitogen-activated protein kinase. (360 aa) |
| | LOC106023000 | DNA endonuclease RBBP8-like. (75 aa) |
| | Taf4 | Transcription initiation factor TFIID subunit 4. (630 aa) |
| | Prkab2 | 5'-AMP-activated protein kinase subunit beta-2 isoform X1. (271 aa) |
| | Dyrk2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2. (601 aa) |
| | LOC101830315 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (50 aa) |
| | Taf2 | Transcription initiation factor TFIID subunit 2 isoform X2. (1112 aa) |
| | Taf7l2 | Transcription initiation factor TFIID subunit 7-like isoform X3. (379 aa) |
| | Mapkapk5 | MAP kinase-activated protein kinase 5. (392 aa) |
| | Cdk3 | Cyclin-dependent kinase 3 isoform X2; Belongs to the protein kinase superfamily. (297 aa) |
| | Dyrk4 | Dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X1. (634 aa) |
| | Ssrp1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | Taf5 | Transcription initiation factor TFIID subunit 5. (803 aa) |
| | Stk11 | Serine/threonine-protein kinase STK11 isoform X2; Belongs to the protein kinase superfamily. (438 aa) |
| | Atr | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2148 aa) |
| | Tp53inp1 | Tumor protein p53-inducible nuclear protein 1 isoform X1. (238 aa) |
| | Ccna1 | cyclin-A1; Belongs to the cyclin family. (421 aa) |
| | ENSMAUP00000012811 | annotation not available (405 aa) |
| | Topbp1 | DNA topoisomerase 2-binding protein 1. (1473 aa) |
| | Noc2l | Nucleolar complex protein 2 homolog. (750 aa) |
| | Taf10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) |
| | Chek1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa) |
| | Slf1 | SMC5-SMC6 complex localization factor protein 1 isoform X1. (1061 aa) |
| | Taf11 | Transcription initiation factor TFIID subunit 11 isoform X1. (211 aa) |
| | LOC101827378 | RNA-binding protein 28. (80 aa) |
| | Tdrd3 | Tudor domain-containing protein 3 isoform X1. (745 aa) |
| | Aurkc | Aurora kinase C. (118 aa) |
| | Dyrk3 | Dual specificity tyrosine-phosphorylation-regulated kinase 3. (587 aa) |
| | Nuak1 | NUAK family SNF1-like kinase 1. (662 aa) |
| | Atm | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3014 aa) |
| | Prkag1 | 5'-AMP-activated protein kinase subunit gamma-1 isoform X2. (330 aa) |
| | Hipk2 | Homeodomain-interacting protein kinase 2; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect [...] (1180 aa) |
| | Pwwp2a | PWWP domain-containing protein 2A isoform X1. (653 aa) |
| | Taf9 | Transcription initiation factor TFIID subunit 9. (264 aa) |
| | Rad50 | DNA repair protein RAD50. (1312 aa) |
| | Rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa) |
| | Chek2 | Serine/threonine-protein kinase Chk2. (539 aa) |
| | LOC101842493 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (236 aa) |
| | Prkag2 | 5'-AMP-activated protein kinase subunit gamma-2 isoform X1. (443 aa) |
| | Prkag3 | 5'-AMP-activated protein kinase subunit gamma-3. (481 aa) |
| | Tpx2 | Targeting protein for Xklp2 isoform X2. (746 aa) |
| | Blm | Bloom syndrome protein. (1415 aa) |
| | ENSMAUP00000007258 | annotation not available (117 aa) |
| | Plk5 | Inactive serine/threonine-protein kinase PLK5. (579 aa) |
| | ENSMAUP00000006950 | annotation not available (259 aa) |
| | Taf6 | Transcription initiation factor TFIID subunit 6 isoform X1. (677 aa) |
| | Aurka | Aurora kinase A; Belongs to the protein kinase superfamily. (401 aa) |
| | Recql4 | ATP-dependent DNA helicase Q4. (1206 aa) |
| | ENSMAUP00000006643 | annotation not available (1305 aa) |
| | LOC101823019 | Ubiquitin-like. (114 aa) |
| | Csnk2a2 | Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (325 aa) |
| | Rbbp8 | DNA endonuclease RBBP8 isoform X1. (813 aa) |
| | ENSMAUP00000006088 | annotation not available (179 aa) |
| | Rps27a | ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | LOC101829779 | Transcription initiation factor TFIID subunit 13. (86 aa) |
| | Hipk3 | Homeodomain-interacting protein kinase 3 isoform X1. (1218 aa) |
| | Prkaa2 | Non-specific serine/threonine protein kinase. (542 aa) |
| | LOC101829779-2 | Transcription initiation factor TFIID subunit 13. (124 aa) |
| | Bard1 | BRCA1-associated RING domain protein 1 isoform X1. (767 aa) |
| | Hipk1 | LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 1. (1040 aa) |
| | Tp53inp2 | Tumor protein p53-inducible nuclear protein 2 isoform X1. (223 aa) |
| | Rfc4 | Replication factor C subunit 4. (362 aa) |
| | Ankrd12 | Ankyrin repeat domain-containing protein 12. (1960 aa) |
| | Tbpl1 | TATA box-binding protein-like protein 1. (186 aa) |
| | Dna2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1005 aa) |
| | Rpa2 | Replication protein A 32 kDa subunit. (270 aa) |
| | Kxd1 | ubiquitin-60S ribosomal protein L40. (232 aa) |
| | ENSMAUP00000002256 | annotation not available (75 aa) |
| | Rad17 | Cell cycle checkpoint protein RAD17 isoform X1. (701 aa) |
| | ENSMAUP00000002060 | annotation not available (103 aa) |
| | Prkaa1 | Non-specific serine/threonine protein kinase. (522 aa) |
| | Taf4b | Transcription initiation factor TFIID subunit 4B. (838 aa) |
| | Pin1 | Peptidyl-prolyl cis-trans isomerase. (165 aa) |
