STRINGSTRING
Akt1 Akt1 Ccna1 Ccna1 Rictor Rictor Cdk3 Cdk3 Mtor Mtor Txndc11 Txndc11 Mapkap1 Mapkap1 ENSMAUP00000002256 ENSMAUP00000002256 Kxd1 Kxd1 Akt3 Akt3 ENSMAUP00000019431 ENSMAUP00000019431 Phf20 Phf20 ENSMAUP00000019554 ENSMAUP00000019554 Ccna2 Ccna2 Ppp2cb Ppp2cb ENSMAUP00000021418 ENSMAUP00000021418 Daxx Daxx Cdk2 Cdk2 ENSMAUP00000022314 ENSMAUP00000022314 Cdk1 Cdk1 Prr5 Prr5 Mlst8 Mlst8 Akt2 Akt2 Rnf34 Rnf34 Prdm1 Prdm1 Ppp2r1b Ppp2r1b MDM2 MDM2 Tp53 Tp53 Ppp2r1a Ppp2r1a Rffl Rffl Rps27a Rps27a Pdpk1 Pdpk1 Usp7 Usp7 LOC101823019 LOC101823019 Ccng1 Ccng1 ENSMAUP00000007258 ENSMAUP00000007258 Sgk1 Sgk1 Ppp2ca Ppp2ca LOC101842493 LOC101842493 Chek2 Chek2 Ppp2r5c Ppp2r5c Atm Atm
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Ccna1cyclin-A1; Belongs to the cyclin family. (421 aa)
RictorRapamycin-insensitive companion of mTOR isoform X2. (1708 aa)
Cdk3Cyclin-dependent kinase 3 isoform X2; Belongs to the protein kinase superfamily. (297 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
Txndc11Thioredoxin domain-containing protein 11 isoform X1. (944 aa)
Mapkap1Target of rapamycin complex 2 subunit MAPKAP1. (330 aa)
ENSMAUP00000002256annotation not available (75 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSMAUP00000019431annotation not available (150 aa)
Phf20PHD finger protein 20 isoform X1. (1008 aa)
ENSMAUP00000019554annotation not available (231 aa)
Ccna2Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. (421 aa)
Ppp2cbProtein phosphatase 2 catalytic subunit beta. (299 aa)
ENSMAUP00000021418annotation not available (290 aa)
DaxxDeath domain-associated protein 6 isoform X1. (131 aa)
Cdk2Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa)
ENSMAUP00000022314annotation not available (101 aa)
Cdk1Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (297 aa)
Prr5Proline-rich protein 5 isoform X1. (387 aa)
Mlst8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Rnf34E3 ubiquitin-protein ligase RNF34. (168 aa)
Prdm1PR domain zinc finger protein 1 isoform X4. (857 aa)
Ppp2r1bSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (693 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
RfflE3 ubiquitin-protein ligase rififylin isoform X4. (394 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X2. (559 aa)
Usp7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (496 aa)
LOC101823019Ubiquitin-like. (114 aa)
Ccng1cyclin-G1; Belongs to the cyclin family. (294 aa)
ENSMAUP00000007258annotation not available (117 aa)
Sgk1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (525 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
LOC101842493Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (236 aa)
Chek2Serine/threonine-protein kinase Chk2. (539 aa)
Ppp2r5cProtein phosphatase 2 regulatory subunit B'gamma. (492 aa)
AtmSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3014 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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