STRINGSTRING
ENSMAUP00000017825 ENSMAUP00000017825 Mcm6 Mcm6 Pole3 Pole3 Rpa3 Rpa3 ENSMAUP00000001221 ENSMAUP00000001221 Cdkn1a Cdkn1a Kiaa2012 Kiaa2012 Pole2 Pole2 LOC101832726 LOC101832726 Psmd13 Psmd13 ENSMAUP00000002060 ENSMAUP00000002060 Skp1 Skp1 ENSMAUP00000002256 ENSMAUP00000002256 Skp2 Skp2 Pole4 Pole4 Kxd1 Kxd1 Rpa2 Rpa2 Ppp4r1 Ppp4r1 Ccne1 Ccne1 Psmb8 Psmb8 ENSMAUP00000003205 ENSMAUP00000003205 Ppp2r1a Ppp2r1a Cdc6 Cdc6 Pola1 Pola1 ENSMAUP00000004913 ENSMAUP00000004913 Psmc3 Psmc3 Psmb9 Psmb9 Psmc6 Psmc6 Rps27a Rps27a Psmc2 Psmc2 LOC101823019 LOC101823019 Psma1 Psma1 Psmd5 Psmd5 Mcm2 Mcm2 Orc6 Orc6 Prim1 Prim1 Cul1 Cul1 ENSMAUP00000007258 ENSMAUP00000007258 Psmc4 Psmc4 ENSMAUP00000007836 ENSMAUP00000007836 ENSMAUP00000007909 ENSMAUP00000007909 Psmb7 Psmb7 Prim2 Prim2 Ppp2ca Ppp2ca Psma2 Psma2 Cks2 Cks2 Rpa1 Rpa1 Cdk4 Cdk4 Crebzf Crebzf ENSMAUP00000009902 ENSMAUP00000009902 Orc5 Orc5 Cks1b Cks1b Psma4 Psma4 Psma7 Psma7 Psmd9 Psmd9 Ccne2 Ccne2 Ppp2r3a Ppp2r3a Psmd7 Psmd7 Psmd6 Psmd6 Psmf1 Psmf1 Wee1 Wee1 Psmd10 Psmd10 Psmc5 Psmc5 Mcm3 Mcm3 Akt1 Akt1 Ccna1 Ccna1 Orc1 Orc1 Wee2 Wee2 Psmd12 Psmd12 Orc4 Orc4 Mcm7 Mcm7 Psmd14 Psmd14 Cdk7 Cdk7 Cdc45 Cdc45 Psmd3 Psmd3 Cdk3 Cdk3 Psmd2 Psmd2 ENSMAUP00000015385 ENSMAUP00000015385 Gmnn Gmnn Psme2 Psme2 Psme1 Psme1 Pola2 Pola2 Psmb4 Psmb4 Mcm9 Mcm9 Psme3 Psme3 ENSMAUP00000016290 ENSMAUP00000016290 Relch Relch Psmb1 Psmb1 Akt3 Akt3 Psmd1 Psmd1 Mcm8 Mcm8 Ppp2r3c Ppp2r3c Ccnh Ccnh Psmb5 Psmb5 Ccnd1 Ccnd1 ENSMAUP00000019431 ENSMAUP00000019431 Dbf4 Dbf4 Cdkn1c Cdkn1c Ccna2 Ccna2 Cdkn1b Cdkn1b ENSMAUP00000020392 ENSMAUP00000020392 Pole Pole Mnat1 Mnat1 Cdc7 Cdc7 Ppp4r4 Ppp4r4 Tm4sf19 Tm4sf19 Mcm4 Mcm4 Ppp2cb Ppp2cb Psmd8 Psmd8 Psmd11 Psmd11 ENSMAUP00000021418 ENSMAUP00000021418 Psmb3 Psmb3 Psma5 Psma5 Cdk2 Cdk2 Orc2 Orc2 Psmc1 Psmc1 ENSMAUP00000022314 ENSMAUP00000022314 Psmd4 Psmd4 Psma6 Psma6 ENSMAUP00000022538 ENSMAUP00000022538 ENSMAUP00000022826 ENSMAUP00000022826 Psmb6 Psmb6 Mcm5 Mcm5 Psma3 Psma3 Akt2 Akt2 Rb1 Rb1 Cables1 Cables1 Ptk6 Ptk6 Psmb2 Psmb2 Meiob Meiob Ppp2r1b Ppp2r1b Cdt1 Cdt1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMAUP00000017825annotation not available (97 aa)
Mcm6DNA helicase; Belongs to the MCM family. (821 aa)
Pole3DNA polymerase epsilon subunit 3. (146 aa)
Rpa3Replication protein A 14 kDa subunit. (121 aa)
ENSMAUP00000001221annotation not available (406 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (163 aa)
Kiaa2012LOW QUALITY PROTEIN: uncharacterized protein KIAA2012 homolog. (835 aa)
Pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (461 aa)
LOC101832726S-phase kinase-associated protein 1 pseudogene. (144 aa)
Psmd1326S proteasome non-ATPase regulatory subunit 13. (369 aa)
ENSMAUP00000002060annotation not available (103 aa)
Skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (158 aa)
ENSMAUP00000002256annotation not available (75 aa)
Skp2S-phase kinase-associated protein 2. (354 aa)
Pole4DNA polymerase epsilon subunit 4. (124 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
Rpa2Replication protein A 32 kDa subunit. (270 aa)
Ppp4r1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (573 aa)
Ccne1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
Psmb8Proteasome subunit beta. (276 aa)
ENSMAUP00000003205annotation not available (93 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
Cdc6Cell division control protein 6 homolog isoform X2. (418 aa)
Pola1DNA polymerase. (1193 aa)
ENSMAUP00000004913annotation not available (165 aa)
Psmc326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (444 aa)
Psmb9Proteasome subunit beta. (219 aa)
Psmc626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (402 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
Psmc2Proteasome 26S subunit, ATPase 2. (349 aa)
LOC101823019Ubiquitin-like. (114 aa)
Psma1Proteasome subunit alpha type. (206 aa)
Psmd526S proteasome non-ATPase regulatory subunit 5. (504 aa)
Mcm2DNA helicase; Belongs to the MCM family. (904 aa)
Orc6Origin recognition complex subunit 6. (253 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (416 aa)
Cul1Cullin-1; Belongs to the cullin family. (776 aa)
ENSMAUP00000007258annotation not available (117 aa)
Psmc426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
ENSMAUP00000007836annotation not available (57 aa)
ENSMAUP00000007909annotation not available (237 aa)
Psmb7Proteasome subunit beta. (277 aa)
Prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (507 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
Psma2Proteasome subunit alpha type. (245 aa)
Cks2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CrebzfCREB/ATF bZIP transcription factor isoform X2. (356 aa)
ENSMAUP00000009902annotation not available (163 aa)
Orc5Origin recognition complex subunit 5. (418 aa)
Cks1bCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Psma4Proteasome subunit alpha type. (261 aa)
Psma7Proteasome subunit alpha type. (145 aa)
Psmd926S proteasome non-ATPase regulatory subunit 9. (202 aa)
Ccne2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
Ppp2r3aSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1103 aa)
Psmd726S proteasome non-ATPase regulatory subunit 7. (320 aa)
Psmd626S proteasome non-ATPase regulatory subunit 6. (389 aa)
Psmf1Proteasome inhibitor PI31 subunit isoform X1. (271 aa)
Wee1Wee1-like protein kinase. (645 aa)
Psmd1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (227 aa)
Psmc526S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
Mcm3DNA helicase; Belongs to the MCM family. (806 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Ccna1cyclin-A1; Belongs to the cyclin family. (421 aa)
Orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (847 aa)
Wee2Wee1-like protein kinase. (550 aa)
Psmd1226S proteasome non-ATPase regulatory subunit 12. (308 aa)
Orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
Mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (704 aa)
Psmd1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
Cdk7Cyclin dependent kinase 7. (224 aa)
Cdc45Cell division control protein 45 homolog. (549 aa)
Psmd326S proteasome non-ATPase regulatory subunit 3. (530 aa)
Cdk3Cyclin-dependent kinase 3 isoform X2; Belongs to the protein kinase superfamily. (297 aa)
Psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (518 aa)
ENSMAUP00000015385annotation not available (72 aa)
GmnnGeminin DNA replication inhibitor. (141 aa)
Psme2Proteasome activator complex subunit 2. (239 aa)
Psme1Proteasome activator complex subunit 1. (249 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
Psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
Mcm9DNA helicase MCM9; Belongs to the MCM family. (1125 aa)
Psme3Proteasome activator complex subunit 3. (254 aa)
ENSMAUP00000016290annotation not available (246 aa)
RelchlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1211 aa)
Psmb1Proteasome subunit beta. (240 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
Mcm8DNA helicase MCM8 isoform X1; Belongs to the MCM family. (833 aa)
Ppp2r3cSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (453 aa)
Ccnhcyclin-H; Belongs to the cyclin family. (324 aa)
Psmb5Proteasome subunit beta. (256 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
ENSMAUP00000019431annotation not available (150 aa)
Dbf4Protein DBF4 homolog A isoform X1. (662 aa)
Cdkn1cCyclin-dependent kinase inhibitor 1C isoform X2. (348 aa)
Ccna2Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. (421 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (198 aa)
ENSMAUP00000020392annotation not available (68 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (663 aa)
Mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (228 aa)
Cdc7Cell division cycle 7-related protein kinase. (514 aa)
Ppp4r4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (875 aa)
Tm4sf19Transmembrane 4 L6 family member 19. (206 aa)
Mcm4DNA helicase; Belongs to the MCM family. (862 aa)
Ppp2cbProtein phosphatase 2 catalytic subunit beta. (299 aa)
Psmd826S proteasome non-ATPase regulatory subunit 8. (180 aa)
Psmd1126S proteasome non-ATPase regulatory subunit 11. (419 aa)
ENSMAUP00000021418annotation not available (290 aa)
Psmb3Proteasome subunit beta. (202 aa)
Psma5Proteasome subunit alpha type. (241 aa)
Cdk2Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa)
Orc2Origin recognition complex subunit 2 isoform X1. (565 aa)
Psmc126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (227 aa)
ENSMAUP00000022314annotation not available (101 aa)
Psmd426S proteasome non-ATPase regulatory subunit 4 isoform X1. (371 aa)
Psma6Proteasome subunit alpha type. (246 aa)
ENSMAUP00000022538annotation not available (95 aa)
ENSMAUP00000022826annotation not available (193 aa)
Psmb6Proteasome subunit beta. (238 aa)
Mcm5DNA helicase; Belongs to the MCM family. (708 aa)
Psma3Proteasome subunit alpha type. (180 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Rb1Retinoblastoma-associated protein. (906 aa)
Cables1CDK5 and ABL1 enzyme substrate 1 isoform X2. (534 aa)
Ptk6Tyrosine-protein kinase. (451 aa)
Psmb2Proteasome subunit beta. (201 aa)
MeiobMeiosis-specific with OB domain-containing protein isoform X1. (470 aa)
Ppp2r1bSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (693 aa)
Cdt1DNA replication factor Cdt1. (541 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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