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MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa) | ||||
Cdkn1a | Cyclin-dependent kinase inhibitor 1. (163 aa) | ||||
Psmd13 | 26S proteasome non-ATPase regulatory subunit 13. (369 aa) | ||||
ENSMAUP00000002256 | annotation not available (75 aa) | ||||
Cop1 | E3 ubiquitin-protein ligase RFWD2 isoform X2. (712 aa) | ||||
Kxd1 | ubiquitin-60S ribosomal protein L40. (232 aa) | ||||
Ccne1 | G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa) | ||||
Psmb8 | Proteasome subunit beta. (276 aa) | ||||
ENSMAUP00000004913 | annotation not available (165 aa) | ||||
Psmc3 | 26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (444 aa) | ||||
Psmb9 | Proteasome subunit beta. (219 aa) | ||||
Psmc6 | 26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (402 aa) | ||||
Rps27a | ubiquitin-40S ribosomal protein S27a. (156 aa) | ||||
Psmc2 | Proteasome 26S subunit, ATPase 2. (349 aa) | ||||
LOC101823019 | Ubiquitin-like. (114 aa) | ||||
Psma1 | Proteasome subunit alpha type. (206 aa) | ||||
Psmd5 | 26S proteasome non-ATPase regulatory subunit 5. (504 aa) | ||||
ENSMAUP00000007258 | annotation not available (117 aa) | ||||
Psmc4 | 26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa) | ||||
ENSMAUP00000007909 | annotation not available (237 aa) | ||||
Psmb7 | Proteasome subunit beta. (277 aa) | ||||
LOC101842493 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (236 aa) | ||||
Psma2 | Proteasome subunit alpha type. (245 aa) | ||||
Chek2 | Serine/threonine-protein kinase Chk2. (539 aa) | ||||
Pwwp2a | PWWP domain-containing protein 2A isoform X1. (653 aa) | ||||
Psma4 | Proteasome subunit alpha type. (261 aa) | ||||
Psma7 | Proteasome subunit alpha type. (145 aa) | ||||
Psme4 | Proteasome activator complex subunit 4 isoform X3. (1843 aa) | ||||
Psmd9 | 26S proteasome non-ATPase regulatory subunit 9. (202 aa) | ||||
Ccne2 | G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa) | ||||
Atm | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3014 aa) | ||||
Psmd7 | 26S proteasome non-ATPase regulatory subunit 7. (320 aa) | ||||
Psmd6 | 26S proteasome non-ATPase regulatory subunit 6. (389 aa) | ||||
Znf385d | Zinc finger protein 385D isoform X2. (365 aa) | ||||
Psmf1 | Proteasome inhibitor PI31 subunit isoform X1. (271 aa) | ||||
Psmd10 | 26S proteasome non-ATPase regulatory subunit 10 isoform X1. (227 aa) | ||||
Psmc5 | 26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa) | ||||
Ccna1 | cyclin-A1; Belongs to the cyclin family. (421 aa) | ||||
Psmd12 | 26S proteasome non-ATPase regulatory subunit 12. (308 aa) | ||||
Tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa) | ||||
Psmd14 | 26S proteasome non-ATPase regulatory subunit 14. (310 aa) | ||||
Psmd3 | 26S proteasome non-ATPase regulatory subunit 3. (530 aa) | ||||
Cdk3 | Cyclin-dependent kinase 3 isoform X2; Belongs to the protein kinase superfamily. (297 aa) | ||||
Psmd2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (518 aa) | ||||
Psme2 | Proteasome activator complex subunit 2. (239 aa) | ||||
Psme1 | Proteasome activator complex subunit 1. (249 aa) | ||||
Psmb4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) | ||||
Psme3 | Proteasome activator complex subunit 3. (254 aa) | ||||
ENSMAUP00000016290 | annotation not available (246 aa) | ||||
Zfp385a | Zinc finger protein 385A isoform X2. (384 aa) | ||||
Psmb1 | Proteasome subunit beta. (240 aa) | ||||
Psmd1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa) | ||||
Psmb11 | Proteasome subunit beta. (280 aa) | ||||
Psma8 | Proteasome subunit alpha type. (237 aa) | ||||
Zfp385b | Zinc finger protein 385B isoform X2. (481 aa) | ||||
Psmb5 | Proteasome subunit beta. (256 aa) | ||||
ENSMAUP00000019431 | annotation not available (150 aa) | ||||
Phf20 | PHD finger protein 20 isoform X1. (1008 aa) | ||||
ENSMAUP00000019554 | annotation not available (231 aa) | ||||
Cdkn1c | Cyclin-dependent kinase inhibitor 1C isoform X2. (348 aa) | ||||
Ccna2 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. (421 aa) | ||||
Cdkn1b | Cyclin-dependent kinase inhibitor 1B. (198 aa) | ||||
ENSMAUP00000020392 | annotation not available (68 aa) | ||||
Psmd8 | 26S proteasome non-ATPase regulatory subunit 8. (180 aa) | ||||
Psmd11 | 26S proteasome non-ATPase regulatory subunit 11. (419 aa) | ||||
Psmb3 | Proteasome subunit beta. (202 aa) | ||||
Psma5 | Proteasome subunit alpha type. (241 aa) | ||||
Cdk2 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa) | ||||
Psmc1 | 26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (227 aa) | ||||
ENSMAUP00000022314 | annotation not available (101 aa) | ||||
Psmd4 | 26S proteasome non-ATPase regulatory subunit 4 isoform X1. (371 aa) | ||||
Psma6 | Proteasome subunit alpha type. (246 aa) | ||||
ENSMAUP00000022538 | annotation not available (95 aa) | ||||
Psmb6 | Proteasome subunit beta. (238 aa) | ||||
Zfp385c | Zinc finger protein 385C. (425 aa) | ||||
Psma3 | Proteasome subunit alpha type. (180 aa) | ||||
Psmb2 | Proteasome subunit beta. (201 aa) |