60 items (Mesocricetus auratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Spata5l1	Spermatogenesis-associated protein 5-like protein 1 isoform X1. (428 aa)
	Usp10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (114 aa)
	Nploc4	Nuclear protein localization protein 4 homolog isoform X1. (618 aa)
	Meiob	Meiosis-specific with OB domain-containing protein isoform X1. (470 aa)
	Uba7	Ubiquitin-like modifier-activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (968 aa)
	Sprtn	sprT-like domain-containing protein Spartan. (502 aa)
	Dtl	Denticleless protein homolog. (124 aa)
	Rad18	E3 ubiquitin-protein ligase RAD18 isoform X2. (453 aa)
	Trim65	Tripartite motif-containing protein 65. (519 aa)
	ENSMAUP00000022826	annotation not available (193 aa)
	Mad2l2	Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
	Rev1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (750 aa)
	ENSMAUP00000022314	annotation not available (101 aa)
	Rchy1	RING finger and CHY zinc finger domain-containing protein 1. (259 aa)
	Atad5	ATPase family AAA domain-containing protein 5. (1819 aa)
	Rcbtb1	RCC1 and BTB domain-containing protein 1 isoform X2. (531 aa)
	Pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (663 aa)
	Rev3l	DNA polymerase zeta catalytic subunit. (2930 aa)
	ENSMAUP00000019431	annotation not available (150 aa)
	Trim47	Tripartite motif-containing protein 47. (641 aa)
	Wdr48	WD repeat-containing protein 48 isoform X2. (678 aa)
	Pclaf	PCNA-associated factor. (97 aa)
	Polk	DNA polymerase kappa. (856 aa)
	Rfc3	Replication factor C subunit 3. (356 aa)
	Pold4	DNA polymerase delta subunit 4. (74 aa)
	Usp43	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family. (971 aa)
	Rfc1	Replication factor C subunit 1. (1063 aa)
	Pold3	DNA polymerase delta subunit 3 isoform X1. (462 aa)
	Usp31	Ubiquitin carboxyl-terminal hydrolase 31; Belongs to the peptidase C19 family. (1175 aa)
	Rcbtb2	RCC1 and BTB domain-containing protein 2 isoform X4. (551 aa)
	Ddb1	DNA damage-binding protein 1 isoform X2. (1140 aa)
	Spata5	Spermatogenesis-associated protein 5 isoform X1. (893 aa)
	Poli	DNA polymerase iota isoform X1. (734 aa)
	Ufd1	Ubiquitin recognition factor in ER-associated degradation protein 1 isoform X1. (307 aa)
	Rbx1	E3 ubiquitin-protein ligase RBX1. (108 aa)
	Pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa)
	Usp1	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (783 aa)
	Polh	DNA polymerase eta isoform X1. (695 aa)
	Isg15	Ubiquitin-like protein ISG15. (160 aa)
	ENSMAUP00000007258	annotation not available (117 aa)
	ENSMAUP00000006950	annotation not available (259 aa)
	LOC101823019	Ubiquitin-like. (114 aa)
	Pold2	DNA polymerase delta subunit 2 isoform X2. (260 aa)
	Rps27a	ubiquitin-40S ribosomal protein S27a. (156 aa)
	Trim25	E3 ubiquitin/ISG15 ligase TRIM25. (602 aa)
	Rfc4	Replication factor C subunit 4. (362 aa)
	Pold1	DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] (1101 aa)
	ENSMAUP00000003260	annotation not available (95 aa)
	Rpa2	Replication protein A 32 kDa subunit. (270 aa)
	Kxd1	ubiquitin-60S ribosomal protein L40. (232 aa)
	Cul4b	cullin-4B; Belongs to the cullin family. (555 aa)
	Pole4	DNA polymerase epsilon subunit 4. (124 aa)
	ENSMAUP00000002256	annotation not available (75 aa)
	ENSMAUP00000002060	annotation not available (103 aa)
	Vcp	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (812 aa)
	Pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (461 aa)
	ENSMAUP00000001221	annotation not available (406 aa)
	Rpa3	Replication protein A 14 kDa subunit. (121 aa)
	Pole3	DNA polymerase epsilon subunit 3. (146 aa)

Your Current Organism:

Mesocricetus auratus

NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atad5	Cul4b	ENSMAUP00000021981	ENSMAUP00000002767	ATPase family AAA domain-containing protein 5.	cullin-4B; Belongs to the cullin family.	0.663
Atad5	Ddb1	ENSMAUP00000021981	ENSMAUP00000012727	ATPase family AAA domain-containing protein 5.	DNA damage-binding protein 1 isoform X2.	0.650
Atad5	Dtl	ENSMAUP00000021981	ENSMAUP00000024102	ATPase family AAA domain-containing protein 5.	Denticleless protein homolog.	0.881
Atad5	ENSMAUP00000001221	ENSMAUP00000021981	ENSMAUP00000001221	ATPase family AAA domain-containing protein 5.	annotation not available	0.851
Atad5	ENSMAUP00000002060	ENSMAUP00000021981	ENSMAUP00000002060	ATPase family AAA domain-containing protein 5.	annotation not available	0.687
Atad5	ENSMAUP00000006950	ENSMAUP00000021981	ENSMAUP00000006950	ATPase family AAA domain-containing protein 5.	annotation not available	0.997
Atad5	ENSMAUP00000019431	ENSMAUP00000021981	ENSMAUP00000019431	ATPase family AAA domain-containing protein 5.	annotation not available	0.634
Atad5	ENSMAUP00000022826	ENSMAUP00000021981	ENSMAUP00000022826	ATPase family AAA domain-containing protein 5.	annotation not available	0.851
Atad5	Isg15	ENSMAUP00000021981	ENSMAUP00000007862	ATPase family AAA domain-containing protein 5.	Ubiquitin-like protein ISG15.	0.536
Atad5	Mad2l2	ENSMAUP00000021981	ENSMAUP00000022750	ATPase family AAA domain-containing protein 5.	Mitotic spindle assembly checkpoint protein MAD2B.	0.684
Atad5	Meiob	ENSMAUP00000021981	ENSMAUP00000025186	ATPase family AAA domain-containing protein 5.	Meiosis-specific with OB domain-containing protein isoform X1.	0.866
Atad5	Pclaf	ENSMAUP00000021981	ENSMAUP00000018497	ATPase family AAA domain-containing protein 5.	PCNA-associated factor.	0.618
Atad5	Pcna	ENSMAUP00000021981	ENSMAUP00000009744	ATPase family AAA domain-containing protein 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.991
Atad5	Pold1	ENSMAUP00000021981	ENSMAUP00000003562	ATPase family AAA domain-containing protein 5.	DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...]	0.869
Atad5	Pold2	ENSMAUP00000021981	ENSMAUP00000006445	ATPase family AAA domain-containing protein 5.	DNA polymerase delta subunit 2 isoform X2.	0.743
Atad5	Pole	ENSMAUP00000021981	ENSMAUP00000020680	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.851
Atad5	Pole2	ENSMAUP00000021981	ENSMAUP00000001461	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.858
Atad5	Pole3	ENSMAUP00000021981	ENSMAUP00000000418	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon subunit 3.	0.810
Atad5	Pole4	ENSMAUP00000021981	ENSMAUP00000002425	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon subunit 4.	0.759
Atad5	Polh	ENSMAUP00000021981	ENSMAUP00000008257	ATPase family AAA domain-containing protein 5.	DNA polymerase eta isoform X1.	0.717

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