STRINGSTRING
Pxn Pxn Arap1 Arap1 Akt1 Akt1 Nrg3 Nrg3 Rasa1 Rasa1 Gpnmb Gpnmb Socs3 Socs3 Nrg2 Nrg2 Cdk4 Cdk4 Lpxn Lpxn Rnf222 Rnf222 Ptpn1 Ptpn1 Elmod1 Elmod1 Elmod3 Elmod3 ENSMAUP00000007258 ENSMAUP00000007258 Stat3 Stat3 Elmo2 Elmo2 Khdrbs3 Khdrbs3 Stap2 Stap2 LOC101823019 LOC101823019 Rps27a Rps27a Sfpq Sfpq Tgfb1i1 Tgfb1i1 LOC106020891 LOC106020891 Eras Eras Ccne1 Ccne1 Kxd1 Kxd1 ENSMAUP00000002256 ENSMAUP00000002256 Hbegf Hbegf Egfr Egfr Btc Btc Arhgap35 Arhgap35 Bcar1 Bcar1 Nrg1 Nrg1 Cbl Cbl Dok1 Dok1 Erbb4 Erbb4 Erbb2 Erbb2 Ptk6 Ptk6 Pspc1 Pspc1 Elmo1 Elmo1 Crk Crk Hras Hras Hif1a Hif1a Nras Nras ENSMAUP00000022314 ENSMAUP00000022314 Cdk2 Cdk2 Elmo3 Elmo3 Cdkn1b Cdkn1b ENSMAUP00000019431 ENSMAUP00000019431 Ccnd1 Ccnd1 Rac1 Rac1 Srms Srms Elmod2 Elmod2 Kras Kras 4930544G11Rik 4930544G11Rik Nono Nono Egf Egf LOC101830046 LOC101830046 Rhoa Rhoa Khdrbs1 Khdrbs1 Nrg4 Nrg4 Csde1 Csde1 Ereg Ereg Lrrk2 Lrrk2 Khdrbs2 Khdrbs2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PxnPaxillin; Belongs to the paxillin family. (589 aa)
Arap1arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1. (1193 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Nrg3Pro-neuregulin-3, membrane-bound isoform. (676 aa)
Rasa1Ras GTPase-activating protein 1 isoform X1. (1037 aa)
GpnmbTransmembrane glycoprotein NMB. (526 aa)
Socs3Suppressor of cytokine signaling 3. (225 aa)
Nrg2Pro-neuregulin-2, membrane-bound isoform. (279 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
LpxnLeupaxin; Belongs to the paxillin family. (381 aa)
Rnf222RING finger protein 222. (211 aa)
Ptpn1Tyrosine-protein phosphatase non-receptor type. (432 aa)
Elmod1ELMO domain-containing protein 1 isoform X4. (326 aa)
Elmod3ELMO domain-containing protein 3 isoform X2. (381 aa)
ENSMAUP00000007258annotation not available (117 aa)
Stat3Signal transducer and activator of transcription. (758 aa)
Elmo2Engulfment and cell motility protein 2 isoform X1. (732 aa)
Khdrbs3KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X1. (321 aa)
Stap2Signal-transducing adaptor protein 2 isoform X1. (411 aa)
LOC101823019Ubiquitin-like. (114 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
SfpqSplicing factor, proline- and glutamine-rich. (703 aa)
Tgfb1i1Transforming growth factor beta-1-induced transcript 1 protein isoform X2; Belongs to the paxillin family. (461 aa)
LOC106020891Dedicator of cytokinesis protein 1; Belongs to the DOCK family. (617 aa)
ErasGTPase ERas. (228 aa)
Ccne1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
ENSMAUP00000002256annotation not available (75 aa)
HbegfProheparin-binding EGF-like growth factor. (202 aa)
EgfrReceptor protein-tyrosine kinase. (1207 aa)
BtcProbetacellulin. (175 aa)
Arhgap35Rho GTPase-activating protein 35. (1499 aa)
Bcar1Breast cancer anti-estrogen resistance protein 1 isoform X3. (874 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform. (655 aa)
CblE3 ubiquitin-protein ligase CBL. (51 aa)
Dok1Docking protein 1. (482 aa)
Erbb4Receptor protein-tyrosine kinase. (1308 aa)
Erbb2Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1247 aa)
Ptk6Tyrosine-protein kinase. (451 aa)
Pspc1Paraspeckle component 1. (454 aa)
Elmo1Engulfment and cell motility protein 1 isoform X1. (727 aa)
CrkAdapter molecule crk isoform X1. (304 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
Hif1aHypoxia-inducible factor 1-alpha isoform X1. (246 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
ENSMAUP00000022314annotation not available (101 aa)
Cdk2Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa)
Elmo3Engulfment and cell motility protein 3 isoform X2. (590 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (198 aa)
ENSMAUP00000019431annotation not available (150 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Rac1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
SrmsTyrosine-protein kinase. (507 aa)
Elmod2ELMO domain-containing protein 2. (164 aa)
KrasGTPase KRas isoform X3. (189 aa)
4930544G11RikTransforming protein RhoA-like isoform X1. (193 aa)
Nononon-POU domain-containing octamer-binding protein. (474 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (254 aa)
LOC101830046Receptor protein-tyrosine kinase. (436 aa)
RhoaTransforming protein RhoA-like isoform X2. (141 aa)
Khdrbs1KH domain-containing, RNA-binding, signal transduction-associated protein 1. (408 aa)
Nrg4Pro-neuregulin-4, membrane-bound isoform. (115 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
EregProepiregulin. (162 aa)
Lrrk2Leucine-rich repeat serine/threonine-protein kinase 2. (2527 aa)
Khdrbs2KH domain-containing, RNA-binding, signal transduction-associated protein 2. (274 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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