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Notch1 | Neurogenic locus notch homolog protein 1 isoform X1. (2532 aa) | ||||
Smad3 | Mothers against decapentaplegic homolog. (425 aa) | ||||
Tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa) | ||||
MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa) | ||||
Psmb2 | Proteasome subunit beta. (201 aa) | ||||
Zfhx4 | Zinc finger homeobox protein 4 isoform X2. (3539 aa) | ||||
Hdac4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa) | ||||
Ccn2 | Connective tissue growth factor. (343 aa) | ||||
Psma3 | Proteasome subunit alpha type. (180 aa) | ||||
Zfhx2 | Zinc finger homeobox protein 2. (2564 aa) | ||||
Psmb6 | Proteasome subunit beta. (238 aa) | ||||
ENSMAUP00000022538 | annotation not available (95 aa) | ||||
Psma6 | Proteasome subunit alpha type. (246 aa) | ||||
Psmd4 | 26S proteasome non-ATPase regulatory subunit 4 isoform X1. (371 aa) | ||||
ENSMAUP00000022314 | annotation not available (101 aa) | ||||
Psmc1 | 26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (227 aa) | ||||
Psma5 | Proteasome subunit alpha type. (241 aa) | ||||
Psmb3 | Proteasome subunit beta. (202 aa) | ||||
Psmd11 | 26S proteasome non-ATPase regulatory subunit 11. (419 aa) | ||||
Psmd8 | 26S proteasome non-ATPase regulatory subunit 8. (180 aa) | ||||
ENSMAUP00000020392 | annotation not available (68 aa) | ||||
Tead4 | Transcriptional enhancer factor TEF-3. (38 aa) | ||||
ENSMAUP00000019431 | annotation not available (150 aa) | ||||
Ccnd1 | G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa) | ||||
Psmb5 | Proteasome subunit beta. (256 aa) | ||||
Tead2 | Transcriptional enhancer factor TEF-4. (431 aa) | ||||
Cbfb | Core-binding factor subunit beta isoform X2. (182 aa) | ||||
Tead1 | Transcriptional enhancer factor TEF-1. (368 aa) | ||||
Psmd1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa) | ||||
Psmb1 | Proteasome subunit beta. (240 aa) | ||||
Tcf7l1 | Transcription factor 7-like 1. (558 aa) | ||||
ENSMAUP00000016290 | annotation not available (246 aa) | ||||
Psme3 | Proteasome activator complex subunit 3. (254 aa) | ||||
Psmb4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) | ||||
Psme1 | Proteasome activator complex subunit 1. (249 aa) | ||||
Psme2 | Proteasome activator complex subunit 2. (239 aa) | ||||
Tcf7l2 | Transcription factor 7-like 2 isoform X17. (598 aa) | ||||
Psmd2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (518 aa) | ||||
Psmd3 | 26S proteasome non-ATPase regulatory subunit 3. (530 aa) | ||||
Psmd14 | 26S proteasome non-ATPase regulatory subunit 14. (310 aa) | ||||
Tead3 | Transcriptional enhancer factor TEF-5. (463 aa) | ||||
Hes1 | Transcription factor HES-1. (281 aa) | ||||
Psmd12 | 26S proteasome non-ATPase regulatory subunit 12. (308 aa) | ||||
Kat2b | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (795 aa) | ||||
Psmc5 | 26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa) | ||||
Psmd10 | 26S proteasome non-ATPase regulatory subunit 10 isoform X1. (227 aa) | ||||
Psmf1 | Proteasome inhibitor PI31 subunit isoform X1. (271 aa) | ||||
Maml2 | Mastermind-like protein 2. (968 aa) | ||||
Psmd6 | 26S proteasome non-ATPase regulatory subunit 6. (389 aa) | ||||
Tcf7 | Transcription factor 7 isoform X3. (303 aa) | ||||
Psmd7 | 26S proteasome non-ATPase regulatory subunit 7. (320 aa) | ||||
Psmd9 | 26S proteasome non-ATPase regulatory subunit 9. (202 aa) | ||||
Fndc3a | Fibronectin type-III domain-containing protein 3A. (1171 aa) | ||||
Psma7 | Proteasome subunit alpha type. (145 aa) | ||||
Psma4 | Proteasome subunit alpha type. (261 aa) | ||||
Maml1 | Mastermind-like protein 1. (1016 aa) | ||||
Smurf2 | E3 ubiquitin-protein ligase. (67 aa) | ||||
Crebzf | CREB/ATF bZIP transcription factor isoform X2. (356 aa) | ||||
Runx3 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (420 aa) | ||||
Src | Tyrosine-protein kinase. (536 aa) | ||||
Psma2 | Proteasome subunit alpha type. (245 aa) | ||||
Smad4 | Mothers against decapentaplegic homolog. (552 aa) | ||||
Psmb7 | Proteasome subunit beta. (277 aa) | ||||
ENSMAUP00000007909 | annotation not available (237 aa) | ||||
Psmc4 | 26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa) | ||||
LOC101827110 | Fibronectin type III domain containing protein 3C1-like. (1355 aa) | ||||
ENSMAUP00000007258 | annotation not available (117 aa) | ||||
Psmd5 | 26S proteasome non-ATPase regulatory subunit 5. (504 aa) | ||||
Psma1 | Proteasome subunit alpha type. (206 aa) | ||||
LOC101823019 | Ubiquitin-like. (114 aa) | ||||
Psmc2 | Proteasome 26S subunit, ATPase 2. (349 aa) | ||||
Rps27a | ubiquitin-40S ribosomal protein S27a. (156 aa) | ||||
Psmc6 | 26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (402 aa) | ||||
Psmb9 | Proteasome subunit beta. (219 aa) | ||||
Psmc3 | 26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (444 aa) | ||||
Brd2 | Bromodomain-containing protein 2 isoform X1. (798 aa) | ||||
ENSMAUP00000004913 | annotation not available (165 aa) | ||||
Lef1 | Lymphoid enhancer-binding factor 1 isoform X2. (397 aa) | ||||
Mamld1 | Mastermind-like domain-containing protein 1. (769 aa) | ||||
Ep300 | Histone acetyltransferase p300 isoform X3. (2417 aa) | ||||
Tgfb1 | Transforming growth factor beta-1. (286 aa) | ||||
Psmb8 | Proteasome subunit beta. (276 aa) | ||||
Kxd1 | ubiquitin-60S ribosomal protein L40. (232 aa) | ||||
ENSMAUP00000002256 | annotation not available (75 aa) | ||||
Fndc3b | Fibronectin type III domain-containing protein 3B isoform X1. (1206 aa) | ||||
Psmd13 | 26S proteasome non-ATPase regulatory subunit 13. (369 aa) | ||||
Maml3 | Mastermind-like protein 3. (1127 aa) | ||||
Ctnnb1 | Catenin beta-1. (781 aa) | ||||
Cdkn1a | Cyclin-dependent kinase inhibitor 1. (163 aa) | ||||
Zfhx3 | Zinc finger homeobox protein 3. (3712 aa) | ||||
Smurf1 | E3 ubiquitin-protein ligase. (679 aa) |