STRINGSTRING
Notch1 Notch1 Smad3 Smad3 Tp53 Tp53 MDM2 MDM2 Psmb2 Psmb2 Zfhx4 Zfhx4 Hdac4 Hdac4 Ccn2 Ccn2 Psma3 Psma3 Zfhx2 Zfhx2 Psmb6 Psmb6 ENSMAUP00000022538 ENSMAUP00000022538 Psma6 Psma6 Psmd4 Psmd4 ENSMAUP00000022314 ENSMAUP00000022314 Psmc1 Psmc1 Psma5 Psma5 Psmb3 Psmb3 Psmd11 Psmd11 Psmd8 Psmd8 ENSMAUP00000020392 ENSMAUP00000020392 Tead4 Tead4 ENSMAUP00000019431 ENSMAUP00000019431 Ccnd1 Ccnd1 Psmb5 Psmb5 Tead2 Tead2 Cbfb Cbfb Tead1 Tead1 Psmd1 Psmd1 Psmb1 Psmb1 Tcf7l1 Tcf7l1 ENSMAUP00000016290 ENSMAUP00000016290 Psme3 Psme3 Psmb4 Psmb4 Psme1 Psme1 Psme2 Psme2 Tcf7l2 Tcf7l2 Psmd2 Psmd2 Psmd3 Psmd3 Psmd14 Psmd14 Tead3 Tead3 Hes1 Hes1 Psmd12 Psmd12 Kat2b Kat2b Psmc5 Psmc5 Psmd10 Psmd10 Psmf1 Psmf1 Maml2 Maml2 Psmd6 Psmd6 Tcf7 Tcf7 Psmd7 Psmd7 Psmd9 Psmd9 Fndc3a Fndc3a Psma7 Psma7 Psma4 Psma4 Maml1 Maml1 Smurf2 Smurf2 Crebzf Crebzf Runx3 Runx3 Src Src Psma2 Psma2 Smad4 Smad4 Psmb7 Psmb7 ENSMAUP00000007909 ENSMAUP00000007909 Psmc4 Psmc4 LOC101827110 LOC101827110 ENSMAUP00000007258 ENSMAUP00000007258 Psmd5 Psmd5 Psma1 Psma1 LOC101823019 LOC101823019 Psmc2 Psmc2 Rps27a Rps27a Psmc6 Psmc6 Psmb9 Psmb9 Psmc3 Psmc3 Brd2 Brd2 ENSMAUP00000004913 ENSMAUP00000004913 Lef1 Lef1 Mamld1 Mamld1 Ep300 Ep300 Tgfb1 Tgfb1 Psmb8 Psmb8 Kxd1 Kxd1 ENSMAUP00000002256 ENSMAUP00000002256 Fndc3b Fndc3b Psmd13 Psmd13 Maml3 Maml3 Ctnnb1 Ctnnb1 Cdkn1a Cdkn1a Zfhx3 Zfhx3 Smurf1 Smurf1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Notch1Neurogenic locus notch homolog protein 1 isoform X1. (2532 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa)
Psmb2Proteasome subunit beta. (201 aa)
Zfhx4Zinc finger homeobox protein 4 isoform X2. (3539 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
Ccn2Connective tissue growth factor. (343 aa)
Psma3Proteasome subunit alpha type. (180 aa)
Zfhx2Zinc finger homeobox protein 2. (2564 aa)
Psmb6Proteasome subunit beta. (238 aa)
ENSMAUP00000022538annotation not available (95 aa)
Psma6Proteasome subunit alpha type. (246 aa)
Psmd426S proteasome non-ATPase regulatory subunit 4 isoform X1. (371 aa)
ENSMAUP00000022314annotation not available (101 aa)
Psmc126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (227 aa)
Psma5Proteasome subunit alpha type. (241 aa)
Psmb3Proteasome subunit beta. (202 aa)
Psmd1126S proteasome non-ATPase regulatory subunit 11. (419 aa)
Psmd826S proteasome non-ATPase regulatory subunit 8. (180 aa)
ENSMAUP00000020392annotation not available (68 aa)
Tead4Transcriptional enhancer factor TEF-3. (38 aa)
ENSMAUP00000019431annotation not available (150 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Psmb5Proteasome subunit beta. (256 aa)
Tead2Transcriptional enhancer factor TEF-4. (431 aa)
CbfbCore-binding factor subunit beta isoform X2. (182 aa)
Tead1Transcriptional enhancer factor TEF-1. (368 aa)
Psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
Psmb1Proteasome subunit beta. (240 aa)
Tcf7l1Transcription factor 7-like 1. (558 aa)
ENSMAUP00000016290annotation not available (246 aa)
Psme3Proteasome activator complex subunit 3. (254 aa)
Psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
Psme1Proteasome activator complex subunit 1. (249 aa)
Psme2Proteasome activator complex subunit 2. (239 aa)
Tcf7l2Transcription factor 7-like 2 isoform X17. (598 aa)
Psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (518 aa)
Psmd326S proteasome non-ATPase regulatory subunit 3. (530 aa)
Psmd1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
Tead3Transcriptional enhancer factor TEF-5. (463 aa)
Hes1Transcription factor HES-1. (281 aa)
Psmd1226S proteasome non-ATPase regulatory subunit 12. (308 aa)
Kat2bHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (795 aa)
Psmc526S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
Psmd1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (227 aa)
Psmf1Proteasome inhibitor PI31 subunit isoform X1. (271 aa)
Maml2Mastermind-like protein 2. (968 aa)
Psmd626S proteasome non-ATPase regulatory subunit 6. (389 aa)
Tcf7Transcription factor 7 isoform X3. (303 aa)
Psmd726S proteasome non-ATPase regulatory subunit 7. (320 aa)
Psmd926S proteasome non-ATPase regulatory subunit 9. (202 aa)
Fndc3aFibronectin type-III domain-containing protein 3A. (1171 aa)
Psma7Proteasome subunit alpha type. (145 aa)
Psma4Proteasome subunit alpha type. (261 aa)
Maml1Mastermind-like protein 1. (1016 aa)
Smurf2E3 ubiquitin-protein ligase. (67 aa)
CrebzfCREB/ATF bZIP transcription factor isoform X2. (356 aa)
Runx3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (420 aa)
SrcTyrosine-protein kinase. (536 aa)
Psma2Proteasome subunit alpha type. (245 aa)
Smad4Mothers against decapentaplegic homolog. (552 aa)
Psmb7Proteasome subunit beta. (277 aa)
ENSMAUP00000007909annotation not available (237 aa)
Psmc426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
LOC101827110Fibronectin type III domain containing protein 3C1-like. (1355 aa)
ENSMAUP00000007258annotation not available (117 aa)
Psmd526S proteasome non-ATPase regulatory subunit 5. (504 aa)
Psma1Proteasome subunit alpha type. (206 aa)
LOC101823019Ubiquitin-like. (114 aa)
Psmc2Proteasome 26S subunit, ATPase 2. (349 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
Psmc626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (402 aa)
Psmb9Proteasome subunit beta. (219 aa)
Psmc326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (444 aa)
Brd2Bromodomain-containing protein 2 isoform X1. (798 aa)
ENSMAUP00000004913annotation not available (165 aa)
Lef1Lymphoid enhancer-binding factor 1 isoform X2. (397 aa)
Mamld1Mastermind-like domain-containing protein 1. (769 aa)
Ep300Histone acetyltransferase p300 isoform X3. (2417 aa)
Tgfb1Transforming growth factor beta-1. (286 aa)
Psmb8Proteasome subunit beta. (276 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
ENSMAUP00000002256annotation not available (75 aa)
Fndc3bFibronectin type III domain-containing protein 3B isoform X1. (1206 aa)
Psmd1326S proteasome non-ATPase regulatory subunit 13. (369 aa)
Maml3Mastermind-like protein 3. (1127 aa)
Ctnnb1Catenin beta-1. (781 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (163 aa)
Zfhx3Zinc finger homeobox protein 3. (3712 aa)
Smurf1E3 ubiquitin-protein ligase. (679 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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