STRINGSTRING
Kras Kras Sh2b3 Sh2b3 Cbl Cbl Csk Csk Akt2 Akt2 Grb10 Grb10 Hras Hras Nras Nras Pik3ca Pik3ca ENSMAUP00000022314 ENSMAUP00000022314 Syk Syk Cdkn1b Cdkn1b ENSMAUP00000019431 ENSMAUP00000019431 Grb2 Grb2 Akt3 Akt3 Csde1 Csde1 Foxo3 Foxo3 Lck Lck Akt1 Akt1 Flt3l Flt3l Flt3 Flt3 Socs2 Socs2 Ptprj Ptprj Hck Hck Gab1 Gab1 ENSMAUP00000007258 ENSMAUP00000007258 LOC101823019 LOC101823019 Grap2 Grap2 Gab2 Gab2 Pik3r1 Pik3r1 Rps27a Rps27a Eras Eras Kxd1 Kxd1 Sla Sla ENSMAUP00000000785 ENSMAUP00000000785 Sos1 Sos1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KrasGTPase KRas isoform X3. (189 aa)
Sh2b3SH2B adapter protein 3 isoform X1. (551 aa)
CblE3 ubiquitin-protein ligase CBL. (51 aa)
CskTyrosine-protein kinase. (450 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Grb10Growth factor receptor-bound protein 10 isoform X2. (584 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSMAUP00000022314annotation not available (101 aa)
SykTyrosine-protein kinase. (629 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (198 aa)
ENSMAUP00000019431annotation not available (150 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
Foxo3Forkhead box protein O3. (672 aa)
LckTyrosine-protein kinase. (316 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Flt3lFms-related tyrosine kinase 3 ligand isoform X1. (199 aa)
Flt3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (922 aa)
Socs2Suppressor of cytokine signaling 2. (198 aa)
PtprjReceptor-type tyrosine-protein phosphatase eta isoform X1. (1272 aa)
HckTyrosine-protein kinase. (519 aa)
Gab1GRB2-associated-binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. (665 aa)
ENSMAUP00000007258annotation not available (117 aa)
LOC101823019Ubiquitin-like. (114 aa)
Grap2GRB2-related adapter protein 2 isoform X1. (324 aa)
Gab2GRB2-associated-binding protein 2 isoform X1. (672 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
ErasGTPase ERas. (228 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
SlaSrc-like-adapter. (298 aa)
ENSMAUP00000000785annotation not available (661 aa)
Sos1Son of sevenless homolog 1. (1319 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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