STRINGSTRING
Ins Ins Ldlr Ldlr Cxcr4 Cxcr4 Apoe Apoe Icam1 Icam1 Bcl2 Bcl2 Pparg Pparg Acox2 Acox2 Abca1 Abca1 Arg1 Arg1 Acox1 Acox1 Cd36 Cd36 Ucp1 Ucp1 Vcam1 Vcam1 Ppara Ppara Acoxl Acoxl Erbb2 Erbb2 Egr2 Egr2 Lep Lep Acox3 Acox3 Adipoq Adipoq
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
InsInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LdlrLow-density lipoprotein receptor isoform X1. (856 aa)
Cxcr4C-X-C chemokine receptor type 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
ApoeApolipoprotein E. (314 aa)
Icam1Intercellular adhesion molecule 1 isoform X2. (516 aa)
Bcl2Apoptosis regulator Bcl-2. (236 aa)
PpargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (217 aa)
Acox2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
Abca1ATP-binding cassette sub-family A member 1 isoform X2. (2261 aa)
Arg1Arginase. (323 aa)
Acox1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
Cd36Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor- ligand complexes. The depende [...] (472 aa)
Ucp1Uncoupling protein 1 (mitochondrial, proton carrier). (168 aa)
Vcam1Vascular cell adhesion protein 1. (736 aa)
PparaPeroxisome proliferator-activated receptor alpha isoform X2. (468 aa)
AcoxlAcyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (597 aa)
Erbb2Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1247 aa)
Egr2E3 SUMO-protein ligase EGR2 isoform X1. (468 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Acox3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
AdipoqAdiponectin isoform X1. (244 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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