STRINGSTRING
Cyp7b1 Cyp7b1 LOC101844449 LOC101844449 LOC101823450 LOC101823450 Srd5a1 Srd5a1 LOC101844897 LOC101844897 LOC101830378 LOC101830378 Sult2b1 Sult2b1 LOC101831527 LOC101831527 ENSMAUP00000024979 ENSMAUP00000024979 Hsd17b7 Hsd17b7 LOC101841752 LOC101841752 LOC101842021 LOC101842021 Cyp21a1 Cyp21a1 LOC101831088 LOC101831088 LOC101843125 LOC101843125 LOC101832144 LOC101832144 Cyp2c70 Cyp2c70 LOC101843587 LOC101843587 Ugt1a1 Ugt1a1 LOC101843034 LOC101843034 Sult1e1 Sult1e1 LOC101841267 LOC101841267 Srd5a3 Srd5a3 Hsd17b1 Hsd17b1 LOC101842056 LOC101842056 LOC101839651 LOC101839651 LOC101843716 LOC101843716 LOC101844487 LOC101844487 Ugt2a3 Ugt2a3 LOC101843930 LOC101843930 LOC101833813 LOC101833813 LOC101822554 LOC101822554 LOC101843667 LOC101843667 Tomt Tomt Sult5a1 Sult5a1 Cyp1a2 Cyp1a2 LOC101840810 LOC101840810 Cyp3a13 Cyp3a13 Akr1d1 Akr1d1 Dhrs11 Dhrs11 LOC101831958 LOC101831958 Cyp7a1 Cyp7a1 Hsd17b12 Hsd17b12 Hsd11b1 Hsd11b1 LOC101838830 LOC101838830 LOC101827747 LOC101827747 LOC101823339 LOC101823339 Cyp1a1 Cyp1a1 Cyp1b1 Cyp1b1 LOC101836914 LOC101836914 Comt Comt Hsd17b8 Hsd17b8 LOC101837099 LOC101837099 LOC101842874 LOC101842874 Cyp19a1 Cyp19a1 Cyp17a1 Cyp17a1 Akr1c19 Akr1c19 LOC101844759 LOC101844759 LOC101844221 LOC101844221 Akr1c18 Akr1c18 Srd5a2 Srd5a2 ENSMAUP00000019005 ENSMAUP00000019005 Sult1d1 Sult1d1 Hsd17b2 Hsd17b2 Akr1c14 Akr1c14 LOC101843311 LOC101843311 Hsd17b3 Hsd17b3 Lrrc51 Lrrc51 Hsd11b2 Hsd11b2 Sult1b1 Sult1b1 LOC101842245 LOC101842245 Tmem165 Tmem165 Ugt2b1 Ugt2b1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cyp7b125-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (509 aa)
LOC101844449UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (288 aa)
LOC101823450Cytochrome P450 2C25-like. (383 aa)
Srd5a13-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (255 aa)
LOC101844897UDP-glucuronosyltransferase 2B4-like. (462 aa)
LOC101830378Cytochrome P450 2C26-like isoform X2; Belongs to the cytochrome P450 family. (490 aa)
Sult2b1Sulfotransferase; Belongs to the sulfotransferase 1 family. (371 aa)
LOC101831527Cytochrome P450 2C19-like; Belongs to the cytochrome P450 family. (490 aa)
ENSMAUP00000024979annotation not available (426 aa)
Hsd17b73-keto-steroid reductase. (347 aa)
LOC101841752Cytochrome P450 2C27-like. (401 aa)
LOC101842021Cytochrome P450 2C26-like; Belongs to the cytochrome P450 family. (217 aa)
Cyp21a1Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. (496 aa)
LOC101831088Cytochrome P450 2C26; Catalyzes the hydroxylation of tolbutamide and the N- demethylation of aminopyrine and benzphetamine. (490 aa)
LOC101843125UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (389 aa)
LOC101832144Cytochrome P450 2C28; Catalyzes the N-demethylation of aminopyrine and benzphetamine, but does not catalyze the hydroxylation of tolbutamide, testosterone, and progesterone; Belongs to the cytochrome P450 family. (490 aa)
Cyp2c70Cytochrome P450 2C70-like; Belongs to the cytochrome P450 family. (489 aa)
LOC101843587Aldo-keto reductase family 1 member C21-like isoform X1. (319 aa)
Ugt1a1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (535 aa)
LOC101843034UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
Sult1e1Sulfotransferase; Belongs to the sulfotransferase 1 family. (295 aa)
LOC101841267prostaglandin-E(2) 9-reductase-like isoform X2. (311 aa)
Srd5a3Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT) (By similarity). (328 aa)
Hsd17b1Estradiol 17-beta-dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (343 aa)
LOC101842056UDP-glucuronosyltransferase 2A2; Belongs to the UDP-glycosyltransferase family. (692 aa)
LOC101839651Aldo-keto reductase family 1 member C21-like. (310 aa)
LOC101843716Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (493 aa)
LOC101844487Cytochrome P450, family 2 subfamily B polypeptide 29; Belongs to the cytochrome P450 family. (491 aa)
Ugt2a3UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa)
LOC101843930UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
LOC101833813Cytochrome P450 2B1-like. (456 aa)
LOC101822554UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
LOC101843667UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
TomtTransmembrane O-methyltransferase. (258 aa)
Sult5a1Sulfotransferase; Belongs to the sulfotransferase 1 family. (291 aa)
Cyp1a2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (513 aa)
LOC101840810Sulfotransferase; Belongs to the sulfotransferase 1 family. (292 aa)
Cyp3a13Cytochrome P450 3A9. (503 aa)
Akr1d13-oxo-5-beta-steroid 4-dehydrogenase. (325 aa)
Dhrs11Dehydrogenase/reductase SDR family member 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
LOC101831958Lithocholate 6-beta-hydroxylase; Catalyzes the 6 beta-hydroxylation of lithocholic acid and steroid hormones; Belongs to the cytochrome P450 family. (503 aa)
Cyp7a1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
Hsd17b12Very-long-chain 3-oxoacyl-CoA reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (253 aa)
Hsd11b1Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta- hydroxycholesterol; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (292 aa)
LOC101838830LOW QUALITY PROTEIN: cytochrome P450 2D20-like; Belongs to the cytochrome P450 family. (476 aa)
LOC101827747Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
LOC101823339Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (319 aa)
Cyp1a1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (507 aa)
Cyp1b1Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (541 aa)
LOC101836914Cytochrome P450 3A31; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (473 aa)
ComtCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (264 aa)
Hsd17b8Estradiol 17-beta-dehydrogenase 8. (259 aa)
LOC101837099NADPH-dependent 3-keto-steroid reductase HSD3B3; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. Belongs to the 3-beta-HSD family. (373 aa)
LOC101842874Aldo-keto reductase family 1 member C13; Catalyzes the dehydrogenation of morphine to morphinone. The enzyme also exhibits significant activity for a variety of cyclic and alicyclic alcohols. In addition to xenobiotics, the enzyme catalyzes the dehydrogenation of 17-beta-hydroxysteroids with much higher affinities than morphine. Uses both NAD and NADP, but the activity is much greater with NAD than with NADP. (323 aa)
Cyp19a1Aromatase; Belongs to the cytochrome P450 family. (503 aa)
Cyp17a1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (431 aa)
Akr1c19Aldo-keto reductase family 1 member C13-like. (251 aa)
LOC101844759Cytochrome P450 2B1-like; Belongs to the cytochrome P450 family. (491 aa)
LOC101844221Cytochrome P450 2B1-like; Belongs to the cytochrome P450 family. (491 aa)
Akr1c18Aldo-keto reductase family 1 member C18 isoform X1. (323 aa)
Srd5a23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (253 aa)
ENSMAUP00000019005annotation not available (354 aa)
Sult1d1Sulfotransferase; Belongs to the sulfotransferase 1 family. (225 aa)
Hsd17b2Estradiol 17-beta-dehydrogenase 2 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (283 aa)
Akr1c143-alpha-hydroxysteroid dehydrogenase-like isoform X1. (323 aa)
LOC1018433113-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase. (323 aa)
Hsd17b3Testosterone 17-beta-dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (217 aa)
Lrrc51Leucine-rich repeat-containing protein 51. (192 aa)
Hsd11b2Corticosteroid 11-beta-dehydrogenase isozyme 2. (401 aa)
Sult1b1Sulfotransferase; Belongs to the sulfotransferase 1 family. (303 aa)
LOC101842245Aldo-keto reductase family 1 member C13-like isoform X1. (311 aa)
Tmem165GDT1 family protein. (321 aa)
Ugt2b1UDP-glucuronosyltransferase 2B1; Belongs to the UDP-glycosyltransferase family. (530 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.