STRINGSTRING
Foxo1 Foxo1 Sesn2 Sesn2 Tp53 Tp53 Ehmt2 Ehmt2 Tsc1 Tsc1 Sod2 Sod2 Pik3r2-2 Pik3r2-2 Prkab1 Prkab1 Camk4 Camk4 Creb3l3 Creb3l3 Irs3 Irs3 Akt2 Akt2 Igf1 Igf1 Irs2 Irs2 Adipoq Adipoq Hras Hras Nras Nras Pik3ca Pik3ca Kl Kl Appl1 Appl1 Adcy3 Adcy3 Ptrhd1 Ptrhd1 Akt1s1 Akt1s1 Sesn1 Sesn1 Atf2 Atf2 Ins Ins Tbca Tbca Creb1 Creb1 Nfkb1 Nfkb1 Rps6kb2 Rps6kb2 Kras Kras Pik3r2 Pik3r2 Atg5 Atg5 Akt3 Akt3 Adcy9 Adcy9 Atg101 Atg101 Mtor Mtor Rela Rela Bax Bax Prkab2 Prkab2 Irs1 Irs1 LOC101836188 LOC101836188 Atf6b Atf6b Rheb Rheb Adcy8 Adcy8 Adcy2 Adcy2 Csde1 Csde1 Foxo3 Foxo3 Stk11 Stk11 Rhebl1 Rhebl1 Eif4ebp1 Eif4ebp1 Akt1 Akt1 Creb3 Creb3 ENSMAUP00000012402 ENSMAUP00000012402 Cat Cat Pparg Pparg Atf4 Atf4 Ppargc1a Ppargc1a Adcy1 Adcy1 Prkag1 Prkag1 Adcy5 Adcy5 Adcy6 Adcy6 Rptor Rptor Atg13 Atg13 Igf1r Igf1r Irs4 Irs4 Adipor2 Adipor2 Sesn3 Sesn3 Prkag2 Prkag2 Prkag3 Prkag3 Creb5 Creb5 Creb3l2 Creb3l2 Sirt1 Sirt1 Pik3r1 Pik3r1 ENSMAUP00000005832 ENSMAUP00000005832 Tsc2 Tsc2 LOC101826865 LOC101826865 Pik3cb Pik3cb Prkaa2 Prkaa2 Adcy7 Adcy7 Prkaca Prkaca Ehmt1 Ehmt1 Ulk1 Ulk1 Adipor1 Adipor1 Eras Eras Camkk2 Camkk2 Creb3l1 Creb3l1 Prkacb Prkacb LOC101831400 LOC101831400 Dhdh Dhdh Eif4e2 Eif4e2 Rb1cc1-2 Rb1cc1-2 Pik3cd Pik3cd Adcy4 Adcy4 Prkaa1 Prkaa1 Rb1cc1 Rb1cc1 Eif4e1b Eif4e1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Foxo1Forkhead box protein O1. (633 aa)
Sesn2Sestrin-2 isoform X2. (480 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
Ehmt2Histone-lysine N-methyltransferase EHMT2 isoform X2. (1249 aa)
Tsc1Hamartin isoform X1. (1160 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Prkab15'-AMP-activated protein kinase subunit beta-1. (270 aa)
Camk4Calcium/calmodulin-dependent protein kinase type IV isoform X1; Belongs to the protein kinase superfamily. (466 aa)
Creb3l3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1. (475 aa)
Irs3Insulin receptor substrate 1-like. (493 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Igf1Insulin-like growth factor 1. (153 aa)
Irs2Insulin receptor substrate 2. (1333 aa)
AdipoqAdiponectin isoform X1. (244 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KlKlotho. (1014 aa)
Appl1DCC-interacting protein 13-alpha. (689 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
Ptrhd1LOW QUALITY PROTEIN: putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
Akt1s1Proline-rich AKT1 substrate 1 isoform X1. (281 aa)
Sesn1Sestrin-1 isoform X1. (551 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (480 aa)
InsInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
TbcaTubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
KrasGTPase KRas isoform X3. (189 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Adcy9Adenylate cyclase type 9 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
Atg101Autophagy-related protein 101. (218 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
BaxApoptosis regulator BAX isoform X1. (192 aa)
Prkab25'-AMP-activated protein kinase subunit beta-2 isoform X1. (271 aa)
Irs1Insulin receptor substrate 1. (1233 aa)
LOC101836188Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (215 aa)
Atf6bCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (73 aa)
RhebGTP-binding protein Rheb. (109 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
Foxo3Forkhead box protein O3. (672 aa)
Stk11Serine/threonine-protein kinase STK11 isoform X2; Belongs to the protein kinase superfamily. (438 aa)
Rhebl1GTPase RhebL1 isoform X2. (182 aa)
Eif4ebp1Eukaryotic translation initiation factor 4E-binding protein 1. (117 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Creb3Cyclic AMP-responsive element-binding protein 3 isoform X1. (386 aa)
ENSMAUP00000012402annotation not available (74 aa)
CatCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
PpargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (217 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (796 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1118 aa)
Prkag15'-AMP-activated protein kinase subunit gamma-1 isoform X2. (330 aa)
Adcy5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
RptorRegulatory-associated protein of mTOR. (1282 aa)
Atg13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (516 aa)
Igf1rTyrosine-protein kinase receptor. (1154 aa)
Irs4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1227 aa)
Adipor2Adiponectin receptor protein 2. (386 aa)
Sesn3Sestrin-3. (492 aa)
Prkag25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (443 aa)
Prkag35'-AMP-activated protein kinase subunit gamma-3. (481 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X3. (508 aa)
Creb3l2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2. (520 aa)
Sirt1NAD-dependent protein deacetylase sirtuin-1. (691 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ENSMAUP00000005832annotation not available (138 aa)
Tsc2Tuberin. (1760 aa)
LOC101826865Cyclic AMP-responsive element-binding protein 3-like protein 4. (213 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
Prkaa2Non-specific serine/threonine protein kinase. (542 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Ehmt1Histone-lysine N-methyltransferase EHMT1 isoform X1. (1294 aa)
Ulk1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1040 aa)
Adipor1Adiponectin receptor protein 1. (375 aa)
ErasGTPase ERas. (228 aa)
Camkk2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (579 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
DhdhTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (297 aa)
Eif4e2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (259 aa)
Rb1cc1-2RB1-inducible coiled-coil protein 1 isoform X2. (227 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
Prkaa1Non-specific serine/threonine protein kinase. (522 aa)
Rb1cc1RB1 inducible coiled-coil 1. (164 aa)
Eif4e1bEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (104 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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