(74 nodes) Notch signaling pathway network (Mesocricetus auratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Dtx3l	E3 ubiquitin-protein ligase DTX3L. (738 aa)
	Ctbp1	C-terminal-binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (417 aa)
	Hey1	Hairy/enhancer-of-split related with YRPW motif protein 1. (278 aa)
	Dtx2	Probable E3 ubiquitin-protein ligase DTX2 isoform X1. (527 aa)
	Dvl3	Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
	Kat2a	Histone acetyltransferase KAT2A isoform X2. (838 aa)
	Cir1	Corepressor interacting with RBPJ 1. (276 aa)
	Dtx3	Probable E3 ubiquitin-protein ligase DTX3 isoform X3. (347 aa)
	Hes5	Transcription factor HES-5. (166 aa)
	Kat2b	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (795 aa)
	ENSMAUP00000013066	annotation not available (356 aa)
	ENSMAUP00000013202	annotation not available (327 aa)
	Hes1	Transcription factor HES-1. (281 aa)
	Gpsm3	G-protein-signaling modulator 3. (116 aa)
	Ncoa7	Nuclear receptor coactivator 7 isoform X3. (221 aa)
	Ncor2	Nuclear receptor corepressor 2 isoform X13. (2511 aa)
	ENSMAUP00000014414	annotation not available (313 aa)
	ENSMAUP00000014706	annotation not available (414 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	ENSMAUP00000015265	annotation not available (289 aa)
	Adam17	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (827 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	Lfng	Beta-1,3-N-acetylglucosaminyltransferase. (199 aa)
	Oxr1	Oxidation resistance protein 1. (216 aa)
	Notch4	Neurogenic locus notch homolog protein 4. (1949 aa)
	Atxn1l	Ataxin-1-like. (688 aa)
	Ncstn	Nicastrin. (709 aa)
	Mfng	Beta-1,3-N-acetylglucosaminyltransferase. (270 aa)
	Hdac2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
	Dvl1	Segment polarity protein dishevelled homolog DVL-1 isoform X1. (695 aa)
	Rbpj	Recombining binding protein suppressor of hairless isoform X1. (526 aa)
	Tle5	Amino-terminal enhancer of split isoform X1. (197 aa)
	Atxn1	Ataxin-1. (790 aa)
	Dvl2	Segment polarity protein dishevelled homolog DVL-2. (299 aa)
	Maml3	Mastermind-like protein 3. (1127 aa)
	Jag2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1225 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	ENSMAUP00000003724	annotation not available (185 aa)
	Ep300	Histone acetyltransferase p300 isoform X3. (2417 aa)
	Ptpre	Receptor-type tyrosine-protein phosphatase. (667 aa)
	LOC101841995	Gamma-secretase subunit APH-1B. (118 aa)
	Mindy3	Ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X2. (444 aa)
	Dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (686 aa)
	Rfng	Beta-1,3-N-acetylglucosaminyltransferase. (328 aa)
	Heyl	Hairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (328 aa)
	Notch3	Neurogenic locus notch homolog protein 3. (2268 aa)
	Notch2	Neurogenic locus notch homolog protein 2. (2470 aa)
	Ptpra	Receptor-type tyrosine-protein phosphatase alpha. (793 aa)
	Snw1	SNW domain-containing protein 1. (536 aa)
	Cnpy3	Protein canopy homolog 3. (274 aa)
	Dll3	Delta-like protein 3. (613 aa)
	Psenen	Gamma-secretase subunit PEN-2. (101 aa)
	Notch1	Neurogenic locus notch homolog protein 1 isoform X1. (2532 aa)
	Bptf	Nucleosome-remodeling factor subunit BPTF isoform X1. (809 aa)
	Dtx4	E3 ubiquitin-protein ligase DTX4. (320 aa)
	Maml2	Mastermind-like protein 2. (968 aa)
	ENSMAUP00000011999	annotation not available (167 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (733 aa)
	Tle3	Transducin-like enhancer protein 3 isoform X1. (782 aa)
	Hdac1	Histone deacetylase 1. (303 aa)
	Tle2	TLE family member 2, transcriptional corepressor. (121 aa)
	Numbl	Numb-like protein isoform X1. (602 aa)
	Hey2	Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
	Dtx1	E3 ubiquitin-protein ligase DTX1 isoform X1. (627 aa)
	Maml1	Mastermind-like protein 1. (1016 aa)
	Tle2-2	Transducin-like enhancer protein 2 isoform X6. (336 aa)
	Tle4	Transducin-like enhancer protein 4 isoform X6. (773 aa)
	Crebbp	CREB-binding protein. (2433 aa)
	Tle6	Transducin-like enhancer protein 6 isoform X1. (523 aa)
	ENSMAUP00000008701	annotation not available (129 aa)
	Vwde	Von Willebrand factor D and EGF domain-containing protein. (1764 aa)
	Aph1a	Gamma-secretase subunit APH-1A. (265 aa)
	Numb	Protein numb homolog isoform X1. (663 aa)
	Ptcra	Pre T-cell antigen receptor alpha. (201 aa)

Your Current Organism:

Mesocricetus auratus

NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	Dll1	ENSMAUP00000016024	ENSMAUP00000012278	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.507
Adam17	Dll4	ENSMAUP00000016024	ENSMAUP00000024594	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.485
Adam17	Jag1	ENSMAUP00000016024	ENSMAUP00000016186	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.556
Adam17	Jag2	ENSMAUP00000016024	ENSMAUP00000002760	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.502
Adam17	Ncstn	ENSMAUP00000016024	ENSMAUP00000022456	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Nicastrin.	0.678
Adam17	Notch1	ENSMAUP00000016024	ENSMAUP00000011153	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Neurogenic locus notch homolog protein 1 isoform X1.	0.900
Adam17	Notch2	ENSMAUP00000016024	ENSMAUP00000017816	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Neurogenic locus notch homolog protein 2.	0.876
Adam17	Notch3	ENSMAUP00000016024	ENSMAUP00000025405	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Neurogenic locus notch homolog protein 3.	0.874
Adam17	Notch4	ENSMAUP00000016024	ENSMAUP00000016934	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Neurogenic locus notch homolog protein 4.	0.873
Adam17	Psen1	ENSMAUP00000016024	ENSMAUP00000003621	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.483
Adam17	Psen2	ENSMAUP00000016024	ENSMAUP00000015058	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.528
Adam17	Psenen	ENSMAUP00000016024	ENSMAUP00000010771	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Gamma-secretase subunit PEN-2.	0.493
Adam17	Ptpra	ENSMAUP00000016024	ENSMAUP00000025645	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Receptor-type tyrosine-protein phosphatase alpha.	0.640
Adam17	Ptpre	ENSMAUP00000016024	ENSMAUP00000005131	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Receptor-type tyrosine-protein phosphatase.	0.640
Adam17	Snw1	ENSMAUP00000016024	ENSMAUP00000018383	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	SNW domain-containing protein 1.	0.412
Adam17	Vwde	ENSMAUP00000016024	ENSMAUP00000008443	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Von Willebrand factor D and EGF domain-containing protein.	0.454
Aph1a	Dll1	ENSMAUP00000007303	ENSMAUP00000012278	Gamma-secretase subunit APH-1A.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.441
Aph1a	Dll4	ENSMAUP00000007303	ENSMAUP00000024594	Gamma-secretase subunit APH-1A.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.433
Aph1a	Gpsm3	ENSMAUP00000007303	ENSMAUP00000013279	Gamma-secretase subunit APH-1A.	G-protein-signaling modulator 3.	0.511
Aph1a	Jag1	ENSMAUP00000007303	ENSMAUP00000016186	Gamma-secretase subunit APH-1A.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.457

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