STRINGSTRING
Gas1 Gas1 Evc Evc Tspan33 Tspan33 Csnk1a1 Csnk1a1 Spop Spop Boc Boc Prkacb Prkacb Fbxw11 Fbxw11 Csnk1e Csnk1e Prkaca Prkaca Gpr161 Gpr161 Spopl Spopl Kif27 Kif27 Lrp2 Lrp2 Csnk1g2 Csnk1g2 Sufu Sufu Ccnd2 Ccnd2 Ptch2 Ptch2 Shh Shh Lrp4 Lrp4 Btrc Btrc Gsk3b Gsk3b Lmbr1 Lmbr1 Csnk1g3 Csnk1g3 Ptch1 Ptch1 Smurf1 Smurf1 Cul1 Cul1 Gli2 Gli2 Gli3 Gli3 Smo Smo Smurf2 Smurf2 Csnk1d Csnk1d Cul3 Cul3 Gli1 Gli1 Bcl2 Bcl2 Mgrn1 Mgrn1 Kif7 Kif7 Atrn Atrn Hhip Hhip Atrnl1 Atrnl1 Mosmo Mosmo Gm19410 Gm19410 Grk3 Grk3 Arrb2 Arrb2 Dhh Dhh Kif3a Kif3a ENSMAUP00000014436 ENSMAUP00000014436 Lmbr1l Lmbr1l Ihh Ihh Evc2 Evc2 Cdon Cdon Grk2 Grk2 Ccnd1 Ccnd1 Megf8 Megf8 Arrb1 Arrb1 Csnk1g1 Csnk1g1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gas1Growth arrest-specific protein 1. (341 aa)
EvcEllis-van Creveld syndrome protein isoform X1. (1004 aa)
Tspan33Tetraspanin. (162 aa)
Csnk1a1Casein kinase I isoform X3; Belongs to the protein kinase superfamily. (336 aa)
SpopSpeckle type BTB/POZ protein. (340 aa)
BocBrother of CDO isoform X3. (1108 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
Fbxw11F-box/WD repeat-containing protein 11 isoform X1. (563 aa)
Csnk1eCasein kinase I isoform X2; Belongs to the protein kinase superfamily. (416 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Gpr161G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (543 aa)
SpoplSpeckle-type POZ protein-like isoform X1. (392 aa)
Kif27Kinesin-like protein KIF27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1372 aa)
Lrp2Low-density lipoprotein receptor-related protein 2. (4244 aa)
Csnk1g2Casein kinase I isoform X2; Belongs to the protein kinase superfamily. (415 aa)
SufuSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (458 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
Ptch2Protein patched homolog 2 isoform X1. (1196 aa)
ShhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (439 aa)
Lrp4Low-density lipoprotein receptor-related protein 4. (1388 aa)
BtrcF-box/WD repeat-containing protein 1A isoform X2. (605 aa)
Gsk3bGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (429 aa)
Lmbr1Limb region 1 protein homolog; Belongs to the LIMR family. (363 aa)
Csnk1g3Casein kinase I isoform X3; Belongs to the protein kinase superfamily. (448 aa)
Ptch1Protein patched homolog 1. (1440 aa)
Smurf1E3 ubiquitin-protein ligase. (679 aa)
Cul1Cullin-1; Belongs to the cullin family. (776 aa)
Gli2Zinc finger protein GLI2. (1544 aa)
Gli3Transcriptional activator GLI3. (1582 aa)
SmoSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (757 aa)
Smurf2E3 ubiquitin-protein ligase. (67 aa)
Csnk1dCasein kinase I isoform X1; Belongs to the protein kinase superfamily. (415 aa)
Cul3Cullin-3; Belongs to the cullin family. (761 aa)
Gli1Zinc finger protein GLI1. (981 aa)
Bcl2Apoptosis regulator Bcl-2. (236 aa)
Mgrn1E3 ubiquitin-protein ligase MGRN1 isoform X7. (546 aa)
Kif7Kinesin-like protein KIF7. (1297 aa)
AtrnAttractin. (1403 aa)
HhipHedgehog-interacting protein isoform X1. (700 aa)
Atrnl1Attractin-like protein 1. (960 aa)
MosmoUncharacterized protein C16orf52 homolog. (167 aa)
Gm19410Very low-density lipoprotein receptor-like. (2095 aa)
Grk3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (675 aa)
Arrb2Beta-arrestin-2. (279 aa)
DhhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
Kif3aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
ENSMAUP00000014436annotation not available (114 aa)
Lmbr1lProtein LMBR1L; Belongs to the LIMR family. (489 aa)
IhhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (363 aa)
Evc2Limbin. (1215 aa)
CdonCell adhesion molecule-related/down-regulated by oncogenes isoform X1. (1254 aa)
Grk2Beta-adrenergic receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner. Positively regulates ciliary smoothened (SMO)- dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Belongs to the protei [...] (689 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Megf8Multiple epidermal growth factor-like domains protein 8. (2789 aa)
Arrb1Beta-arrestin-1 isoform X3. (418 aa)
Csnk1g1Casein kinase I isoform X2; Belongs to the protein kinase superfamily. (459 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.