STRINGSTRING
Lats1 Lats1 Fzd6 Fzd6 Sox3 Sox3 Wwtr1 Wwtr1 Fzd4 Fzd4 Fzd1 Fzd1 Dvl2 Dvl2 Nkd1 Nkd1 Ppp2r2b Ppp2r2b Limd1 Limd1 Dlg3 Dlg3 Ppp1cc Ppp1cc Ctnna2 Ctnna2 Ctnnb1 Ctnnb1 Amot Amot Id1 Id1 Wnt6 Wnt6 Ywhaz Ywhaz Ppp2r2d Ppp2r2d Bmp4 Bmp4 Wnt8b Wnt8b Amh Amh Birc2 Birc2 Wnt3 Wnt3 Sav1 Sav1 Bmp5 Bmp5 Dvl3 Dvl3 Ppp2cb Ppp2cb ENSMAUP00000021418 ENSMAUP00000021418 Rassf6 Rassf6 Llgl1 Llgl1 Ppp2r2a Ppp2r2a Dlg4 Dlg4 Smad1 Smad1 Actl11 Actl11 Smad7 Smad7 Dvl1 Dvl1 Lats2 Lats2 Fzd3 Fzd3 Prkci Prkci Ctnna1 Ctnna1 Ccn2 Ccn2 Wnt3a Wnt3a Patj Patj Wnt5b Wnt5b Wnt9a Wnt9a Apc2 Apc2 Itgb2 Itgb2 ENSMAUP00000025330 ENSMAUP00000025330 Fzd2 Fzd2 Birc5 Birc5 Fzd5 Fzd5 Ppp2r1b Ppp2r1b Dlg1 Dlg1 Smad3 Smad3 Ywhah Ywhah Actg1 Actg1 ENSMAUP00000002507 ENSMAUP00000002507 Tgfbr2 Tgfbr2 Wnt10a Wnt10a Serpine1 Serpine1 Fbxw11 Fbxw11 Ppp2r1a Ppp2r1a Tgfb1 Tgfb1 Csnk1e Csnk1e Actl9 Actl9 Actl7a Actl7a Ywhab Ywhab Wnt2b Wnt2b Lef1 Lef1 Tgfb3 Tgfb3 Actl7b Actl7b Smad2 Smad2 ENSMAUP00000005106 ENSMAUP00000005106 Sox1 Sox1 Axin2 Axin2 Myc Myc Nf2 Nf2 Fzd10 Fzd10 Axin1 Axin1 Snai2 Snai2 Bmyc Bmyc Wnt11 Wnt11 Pard6a Pard6a Actb Actb Gli2 Gli2 Lrrc1 Lrrc1 Bmpr2 Bmpr2 Bbc3 Bbc3 ENSMAUP00000007597 ENSMAUP00000007597 Fzd9 Fzd9 Albfm1 Albfm1 Pard6g Pard6g ENSMAUP00000008058 ENSMAUP00000008058 Ppp2ca Ppp2ca Wtip Wtip Smad4 Smad4 Actrt2 Actrt2 Wnt7b Wnt7b Tgfb2 Tgfb2 Wnt8a Wnt8a Ccnd3 Ccnd3 Fzd7 Fzd7 Ywhae Ywhae Tp73 Tp73 Pard6b Pard6b Csnk1d Csnk1d Bmp6 Bmp6 Bmpr1b Bmpr1b Wnt4 Wnt4 Gdf5 Gdf5 Nkd2 Nkd2 Pard3 Pard3 Fgf1 Fgf1 Mob1b Mob1b Gdf7 Gdf7 Wnt10b Wnt10b Wnt1 Wnt1 Tcf7 Tcf7 Wnt2 Wnt2 Id2 Id2 Dlg2 Dlg2 Scrib Scrib Areg Areg Mpp5 Mpp5 Ctnna3 Ctnna3 Gdf6 Gdf6 Tead3 Tead3 Tgfbr1 Tgfbr1 Afp Afp Ppp2r2c Ppp2r2c Apc Apc Dlg5 Dlg5 Tcf7l2 Tcf7l2 Wnt5a Wnt5a Fzd8 Fzd8 Ajuba Ajuba Bmp2 Bmp2 Wnt16 Wnt16 Crb1 Crb1 Cdh1 Cdh1 Ppp1cb Ppp1cb Bmp7 Bmp7 Llgl2 Llgl2 Tcf7l1 Tcf7l1 Gsk3b Gsk3b LOC101835135 LOC101835135 ENSMAUP00000016945 ENSMAUP00000016945 Frmd6 Frmd6 Btrc Btrc Ppp1ca Ppp1ca Bmpr1a Bmpr1a Prkcz Prkcz Tead1 Tead1 Ywhag Ywhag Wnt7a Wnt7a Actrt1 Actrt1 Stk3 Stk3 ENSMAUP00000018035 ENSMAUP00000018035 Trp53bp2 Trp53bp2 Ccnd2 Ccnd2 Myo15 Myo15 Sox2 Sox2 Ywhaq Ywhaq LOC101823400 LOC101823400 Rassf1 Rassf1 Wnt9b Wnt9b Wwc1 Wwc1 Crb2 Crb2 Tead2 Tead2 Ccnd1 Ccnd1 Myo15b Myo15b Tead4 Tead4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Lats1Serine/threonine-protein kinase LATS1. (1077 aa)
Fzd6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (684 aa)
Sox3Transcription factor SOX-3. (335 aa)
Wwtr1WW domain-containing transcription regulator protein 1 isoform X2. (395 aa)
Fzd4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (535 aa)
Fzd1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
Dvl2Segment polarity protein dishevelled homolog DVL-2. (299 aa)
Nkd1Protein naked cuticle homolog 1. (471 aa)
Ppp2r2bProtein phosphatase 2, regulatory subunit B, beta. (288 aa)
Limd1LIM domain-containing protein 1 isoform X1. (651 aa)
Dlg3Disks large homolog 3 isoform X4; Belongs to the MAGUK family. (849 aa)
Ppp1ccProtein phosphatase 1 catalytic subunit gamma. (216 aa)
Ctnna2Catenin alpha-2 isoform X1. (965 aa)
Ctnnb1Catenin beta-1. (781 aa)
AmotAngiomotin isoform X1. (1099 aa)
Id1DNA-binding protein inhibitor ID-1 isoform X2. (151 aa)
Wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
Ywhaz14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (212 aa)
Ppp2r2dSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
Bmp4Bone morphogenetic protein 4. (409 aa)
Wnt8bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
AmhMuellerian-inhibiting factor. (554 aa)
Birc2Baculoviral IAP repeat-containing protein 2. (592 aa)
Wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
Sav1Protein salvador homolog 1. (387 aa)
Bmp5Bone morphogenetic protein 5. (454 aa)
Dvl3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
Ppp2cbProtein phosphatase 2 catalytic subunit beta. (299 aa)
ENSMAUP00000021418annotation not available (290 aa)
Rassf6Ras association domain-containing protein 6 isoform X1. (337 aa)
Llgl1Lethal(2) giant larvae protein homolog 1. (1061 aa)
Ppp2r2aSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
Dlg4Disks large homolog 4 isoform X2; Belongs to the MAGUK family. (706 aa)
Smad1Mothers against decapentaplegic homolog. (465 aa)
Actl11Uncharacterized protein LOC101835075; Belongs to the actin family. (1219 aa)
Smad7Mothers against decapentaplegic homolog. (427 aa)
Dvl1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (695 aa)
Lats2Non-specific serine/threonine protein kinase. (966 aa)
Fzd3Frizzled-3 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PrkciProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
Ctnna1Catenin alpha-1. (905 aa)
Ccn2Connective tissue growth factor. (343 aa)
Wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PatjinaD-like protein. (1773 aa)
Wnt5bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
Wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (191 aa)
Apc2Adenomatous polyposis coli protein 2 isoform X3. (2286 aa)
Itgb2Integrin beta. (304 aa)
ENSMAUP00000025330annotation not available (154 aa)
Fzd2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (567 aa)
Birc5Baculoviral IAP repeat-containing protein 5. (142 aa)
Fzd5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
Ppp2r1bSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (693 aa)
Dlg1Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (925 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
YwhahTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta. (176 aa)
Actg1Actin gamma 1. (133 aa)
ENSMAUP00000002507annotation not available (120 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Wnt10aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (418 aa)
Serpine1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
Fbxw11F-box/WD repeat-containing protein 11 isoform X1. (563 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
Tgfb1Transforming growth factor beta-1. (286 aa)
Csnk1eCasein kinase I isoform X2; Belongs to the protein kinase superfamily. (416 aa)
Actl9Actin-like protein 9; Belongs to the actin family. (415 aa)
Actl7aActin-like protein 7A; Belongs to the actin family. (440 aa)
Ywhab14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (110 aa)
Wnt2bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
Lef1Lymphoid enhancer-binding factor 1 isoform X2. (397 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Actl7bActin-like protein 7B; Belongs to the actin family. (417 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
ENSMAUP00000005106annotation not available (174 aa)
Sox1Transcription factor SOX-1. (370 aa)
Axin2Axin-2. (70 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
Nf2Merlin isoform X1. (596 aa)
Fzd10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
Axin1Axin-1 isoform X1. (868 aa)
Snai2Zinc finger protein SNAI2. (268 aa)
BmycProtein B-Myc. (173 aa)
Wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
Pard6aPartitioning defective 6 homolog alpha isoform X1. (346 aa)
ActbActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
Gli2Zinc finger protein GLI2. (1544 aa)
Lrrc1Leucine-rich repeat-containing protein 1. (524 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (832 aa)
Bbc3Bcl-2-binding component 3 isoform X2. (193 aa)
ENSMAUP00000007597annotation not available (215 aa)
Fzd9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
Albfm1Alpha-fetoprotein-like isoform X1. (624 aa)
Pard6gPartitioning defective 6 homolog gamma. (383 aa)
ENSMAUP00000008058annotation not available (207 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
WtipWilms tumor protein 1-interacting protein. (221 aa)
Smad4Mothers against decapentaplegic homolog. (552 aa)
Actrt2Actin-related protein T2; Belongs to the actin family. (377 aa)
Wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Wnt8aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
Ccnd3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
Fzd7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (572 aa)
Ywhae14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa)
Tp73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (286 aa)
Pard6bPartitioning defective 6 homolog beta. (370 aa)
Csnk1dCasein kinase I isoform X1; Belongs to the protein kinase superfamily. (415 aa)
Bmp6Bone morphogenetic protein 6. (502 aa)
Bmpr1bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (297 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Gdf5Growth/differentiation factor 5. (495 aa)
Nkd2Protein naked cuticle homolog 2 isoform X2. (460 aa)
Pard3Partitioning defective 3 homolog isoform X3. (1334 aa)
Fgf1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (155 aa)
Mob1bMOB kinase activator 1B. (216 aa)
Gdf7Growth/differentiation factor 7. (442 aa)
Wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
Wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Tcf7Transcription factor 7 isoform X3. (303 aa)
Wnt2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
Id2DNA-binding protein inhibitor ID-2. (134 aa)
Dlg2Disks large homolog 2; Belongs to the MAGUK family. (844 aa)
ScribProtein scribble homolog. (1551 aa)
AregAmphiregulin. (248 aa)
Mpp5MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. (675 aa)
Ctnna3Catenin alpha-3. (799 aa)
Gdf6Growth/differentiation factor 6. (451 aa)
Tead3Transcriptional enhancer factor TEF-5. (463 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
AfpAlpha-fetoprotein. (609 aa)
Ppp2r2cSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
ApcAdenomatous polyposis coli protein isoform X4. (492 aa)
Dlg5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1894 aa)
Tcf7l2Transcription factor 7-like 2 isoform X17. (598 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Fzd8LOW QUALITY PROTEIN: frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (675 aa)
AjubaLIM domain-containing protein ajuba. (521 aa)
Bmp2Bone morphogenetic protein 2 isoform X1. (394 aa)
Wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
Crb1Protein crumbs homolog 1. (1403 aa)
Cdh1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
Ppp1cbProtein phosphatase 1 catalytic subunit beta. (298 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Llgl2Lethal(2) giant larvae protein homolog 2 isoform X2. (1178 aa)
Tcf7l1Transcription factor 7-like 1. (558 aa)
Gsk3bGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (429 aa)
LOC101835135Actin-like protein 9; Belongs to the actin family. (411 aa)
ENSMAUP00000016945annotation not available (190 aa)
Frmd6FERM domain-containing protein 6 isoform X1. (619 aa)
BtrcF-box/WD repeat-containing protein 1A isoform X2. (605 aa)
Ppp1caSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
Bmpr1aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PrkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
Tead1Transcriptional enhancer factor TEF-1. (368 aa)
Ywhag14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
Wnt7aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (318 aa)
Actrt1Actin-related protein T1; Belongs to the actin family. (376 aa)
Stk3Serine/threonine-protein kinase 3. (468 aa)
ENSMAUP00000018035annotation not available (272 aa)
Trp53bp2Transformation related protein 53 binding protein 2. (753 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
Myo15Unconventional myosin-XV; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3481 aa)
Sox2Transcription factor SOX-2. (319 aa)
Ywhaq14-3-3 protein theta; Belongs to the 14-3-3 family. (278 aa)
LOC10182340014-3-3 protein theta pseudogene. (252 aa)
Rassf1Ras association domain-containing protein 1. (340 aa)
Wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
Wwc1Protein KIBRA. (1060 aa)
Crb2Protein crumbs homolog 2. (1280 aa)
Tead2Transcriptional enhancer factor TEF-4. (431 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Myo15bMyosin XVB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (512 aa)
Tead4Transcriptional enhancer factor TEF-3. (38 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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