STRINGSTRING
Il6 Il6 Il1b Il1b Tlr9 Tlr9 Ly96 Ly96 Chuk Chuk Mapk9 Mapk9 Cd14 Cd14 Mapk13 Mapk13 Mapk1 Mapk1 Tlr4 Tlr4 Mapk10 Mapk10 Pik3r2 Pik3r2 Map3k7 Map3k7 Bpi Bpi Akt3 Akt3 Tirap Tirap Tlr5 Tlr5 Mapk14 Mapk14 Irak4 Irak4 Tollip Tollip Bpifc Bpifc Pik3cd Pik3cd LOC101831400 LOC101831400 Irak1 Irak1 Map2k7 Map2k7 Map3k8 Map3k8 Tlr8 Tlr8 LOC101824534 LOC101824534 Traf6 Traf6 Nfkbia Nfkbia Mapk8 Mapk8 Il12a Il12a Lbp Lbp Pik3cb Pik3cb Jun Jun Tlr6 Tlr6 Pik3r1 Pik3r1 Ikbke Ikbke Ikbkg Ikbkg Myd88 Myd88 Tab2 Tab2 Map2k1 Map2k1 Map2k2 Map2k2 Tmed3 Tmed3 Mapk3 Mapk3 Cd40 Cd40 Akt1 Akt1 Ifnar1 Ifnar1 Cxcl10 Cxcl10 Tnf Tnf Ikbkb Ikbkb Stat1 Stat1 Rela Rela Tlr2 Tlr2 Tmed7 Tmed7 Tbk1 Tbk1 Ripk1 Ripk1 Tlr1 Tlr1 Mapk11 Mapk11 Irf3 Irf3 Mapk12 Mapk12 Tab1 Tab1 Traf3 Traf3 Tlr3 Tlr3 Ccl3 Ccl3 Pik3r2-2 Pik3r2-2 Irf5 Irf5 Map2k6 Map2k6 Akt2 Akt2 Ccl4 Ccl4 Cxcl11 Cxcl11 Map2k3 Map2k3 Irf7 Irf7 Pik3ca Pik3ca Cd80 Cd80 Cd86 Cd86 Fos Fos Ctsk Ctsk Irf6 Irf6 Casp8 Casp8 Ticam1 Ticam1 Spp1 Spp1 Nfkb1 Nfkb1 Ticam2 Ticam2 Tlr7 Tlr7 Fadd Fadd Rac1 Rac1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Il6Interleukin-6. (212 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Tlr9Toll-like receptor 9. (1030 aa)
Ly96Lymphocyte antigen 96. (74 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
Cd14Monocyte differentiation antigen CD14. (370 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (497 aa)
BpiBactericidal permeability-increasing protein. (481 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TirapToll/interleukin-1 receptor domain-containing adapter protein isoform X2. (245 aa)
Tlr5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Irak4Interleukin-1 receptor-associated kinase 4. (461 aa)
TollipToll-interacting protein. (274 aa)
BpifcBPI fold-containing family C protein. (507 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
Irak1Interleukin-1 receptor-associated kinase 1 isoform X2. (747 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (520 aa)
Map3k8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
Tlr8Toll-like receptor 8 isoform X1; Belongs to the Toll-like receptor family. (1028 aa)
LOC101824534Interferon alpha-12-like. (183 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
NfkbiaNF-kappa-B inhibitor alpha. (314 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (206 aa)
LbpLipopolysaccharide-binding protein. (481 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
Tlr6Toll-like receptor 6; Belongs to the Toll-like receptor family. (789 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (715 aa)
IkbkgNF-kappa-B essential modulator isoform X1. (412 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Tmed3Transmembrane emp24 domain-containing protein 3. (220 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Cd40Tumor necrosis factor receptor superfamily member 5 isoform X2. (290 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Ifnar1Interferon alpha/beta receptor 1. (543 aa)
Cxcl10C-X-C motif chemokine. (98 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (757 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
Tlr2Toll-like receptor. (784 aa)
Tmed7Transmembrane emp24 domain-containing protein 7. (225 aa)
Tbk1Serine/threonine-protein kinase TBK1. (729 aa)
Ripk1Receptor-interacting serine/threonine-protein kinase 1. (658 aa)
Tlr1Toll-like receptor 1; Belongs to the Toll-like receptor family. (794 aa)
Mapk11Mitogen-activated protein kinase. (355 aa)
Irf3Interferon regulatory factor 3 isoform X1. (420 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
Tab1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (254 aa)
Traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
Tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
Ccl3C-C motif chemokine. (98 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Irf5Interferon regulatory factor 5. (432 aa)
Map2k6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Ccl4C-C motif chemokine. (92 aa)
Cxcl11C-X-C motif chemokine. (99 aa)
Map2k3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
Irf7Interferon regulatory factor 7 isoform X1. (394 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Cd80T-lymphocyte activation antigen CD80 isoform X1. (294 aa)
Cd86T-lymphocyte activation antigen CD86 precursor. (263 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
CtskCathepsin K isoform X1; Belongs to the peptidase C1 family. (329 aa)
Irf6Interferon regulatory factor 6. (467 aa)
Casp8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (481 aa)
Ticam1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (733 aa)
Spp1Osteopontin precursor. (305 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Ticam2TIR domain-containing adapter molecule 2. (233 aa)
Tlr7Toll-like receptor 7 isoform X1; Belongs to the Toll-like receptor family. (1050 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
Rac1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.