STRINGSTRING
Ikbkb Ikbkb Usp25 Usp25 Rela Rela Mapk15 Mapk15 Il17b Il17b Fosl1 Fosl1 Gsk3b Gsk3b Ccl11 Ccl11 Mapk14 Mapk14 S100a7a S100a7a LOC101827575 LOC101827575 Il25 Il25 Map3k7 Map3k7 LOC101834882 LOC101834882 Mapk10 Mapk10 Mapk1 Mapk1 Defb4b Defb4b Traf4 Traf4 LOC101824185 LOC101824185 ENSMAUP00000008492 ENSMAUP00000008492 Il5 Il5 Il4 Il4 Il13 Il13 Csf2 Csf2 Ikbkg Ikbkg Ikbke Ikbke Jun Jun ENSMAUP00000004933 ENSMAUP00000004933 Mapk8 Mapk8 Nfkbia Nfkbia LOC101830989 LOC101830989 ENSMAUP00000004541 ENSMAUP00000004541 Mmp9 Mmp9 Traf6 Traf6 Casp3 Casp3 Mapk6 Mapk6 Il17re Il17re Traf5 Traf5 Mmp13 Mmp13 Fosb Fosb Elavl1 Elavl1 Traf2 Traf2 Tab3 Tab3 Tbk1 Tbk1 Ccl17 Ccl17 Tradd Tradd Mapk4 Mapk4 Mapk13 Mapk13 Mapk9 Mapk9 Chuk Chuk Il1b Il1b Il6 Il6 Fadd Fadd Nfkb1 Nfkb1 Anapc5 Anapc5 Hsp90ab1 Hsp90ab1 Casp8 Casp8 Ptgs2 Ptgs2 S100a8 S100a8 Traf3ip2-2 Traf3ip2-2 Il17rb Il17rb Fos Fos Tnfaip3 Tnfaip3 Hsp90b1 Hsp90b1 Muc5ac Muc5ac Cxcl5 Cxcl5 Jund Jund Ccl20 Ccl20 Ccl2 Ccl2 Muc2 Muc2 Il17ra Il17ra Traf3 Traf3 Csf3 Csf3 Srsf1 Srsf1 Mapk12 Mapk12 ENSMAUP00000025679 ENSMAUP00000025679 Mapk11 Mapk11 Tab2 Tab2 LOC101831206 LOC101831206 Il17c Il17c Mmp3 Mmp3 Mapk3 Mapk3 Mapk7 Mapk7 Lcn2 Lcn2 Ccl12 Ccl12 Traf3ip2 Traf3ip2 Ifng Ifng Il17a Il17a Cxcl10 Cxcl10 Tnf Tnf Ccl7 Ccl7 Il17f Il17f
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (757 aa)
Usp25Ubiquitin carboxyl-terminal hydrolase 25 isoform X1; Belongs to the peptidase C19 family. (1055 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
Mapk15Mitogen-activated protein kinase. (539 aa)
Il17bInterleukin-17B; Stimulates the release of tumor necrosis factor alpha and IL- 1-beta from the monocytic cell line THP-1; Belongs to the IL-17 family. (103 aa)
Fosl1Fos-related antigen 1. (172 aa)
Gsk3bGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (429 aa)
Ccl11C-C motif chemokine. (97 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
S100a7aProtein S100-A15A. (108 aa)
LOC101827575C-X-C motif chemokine. (68 aa)
Il25Interleukin-25. (168 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (497 aa)
LOC101834882C-X-C motif chemokine. (96 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Defb4bBeta-defensin 4B. (63 aa)
Traf4TNF receptor-associated factor. (470 aa)
LOC101824185Interstitial collagenase A. (465 aa)
ENSMAUP00000008492annotation not available (391 aa)
Il5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (121 aa)
Il4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (147 aa)
Il13Interleukin-13. (133 aa)
Csf2Granulocyte-macrophage colony-stimulating factor. (142 aa)
IkbkgNF-kappa-B essential modulator isoform X1. (412 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (715 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
ENSMAUP00000004933annotation not available (593 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
NfkbiaNF-kappa-B inhibitor alpha. (314 aa)
LOC101830989Protein S100-A9; Belongs to the S-100 family. (113 aa)
ENSMAUP00000004541annotation not available (622 aa)
Mmp9Matrix metalloproteinase-9. (718 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
Casp3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (246 aa)
Mapk6Mitogen-activated protein kinase 6. (722 aa)
Il17reInterleukin-17 receptor E. (640 aa)
Traf5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (550 aa)
Mmp13Collagenase 3. (471 aa)
FosbProtein fosB isoform X1. (338 aa)
Elavl1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
Traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
Tab3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2. (715 aa)
Tbk1Serine/threonine-protein kinase TBK1. (729 aa)
Ccl17C-C motif chemokine. (103 aa)
TraddTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (310 aa)
Mapk4Mitogen-activated protein kinase 4. (583 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Il6Interleukin-6. (212 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Anapc5Anaphase-promoting complex subunit 5. (84 aa)
Hsp90ab1Heat shock protein HSP 90-beta. (724 aa)
Casp8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (481 aa)
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
S100a8Protein S100; Belongs to the S-100 family. (89 aa)
Traf3ip2-2Adapter protein CIKS isoform X2. (264 aa)
Il17rbInterleukin-17 receptor B-like. (368 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
Tnfaip3Tumor necrosis factor alpha-induced protein 3 isoform X1. (776 aa)
Hsp90b1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (802 aa)
Muc5acmucin-5AC. (2650 aa)
Cxcl5C-X-C motif chemokine. (129 aa)
JundTranscription factor jun-D. (341 aa)
Ccl20C-C motif chemokine. (101 aa)
Ccl2C-C motif chemokine. (143 aa)
Muc2Mucin-2. (483 aa)
Il17raInterleukin-17 receptor A. (857 aa)
Traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
Csf3Granulocyte colony-stimulating factor. (208 aa)
Srsf1Serine/arginine-rich splicing factor 1. (253 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
ENSMAUP00000025679annotation not available (108 aa)
Mapk11Mitogen-activated protein kinase. (355 aa)
Tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
LOC101831206Interleukin-17 receptor C. (308 aa)
Il17cinterleukin-17C. (195 aa)
Mmp3Stromelysin-1. (359 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
Lcn2Neutrophil gelatinase-associated lipocalin; Belongs to the calycin superfamily. Lipocalin family. (198 aa)
Ccl12C-C motif chemokine. (105 aa)
Traf3ip2Adapter protein CIKS isoform X4. (109 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (174 aa)
Il17ainterleukin-17A. (158 aa)
Cxcl10C-X-C motif chemokine. (98 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Ccl7C-C motif chemokine. (97 aa)
Il17finterleukin-17F. (162 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.