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Pik3cd Pik3cd Rasgrp1 Rasgrp1 Ppp3r2 Ppp3r2 LOC101831400 LOC101831400 Map2k7 Map2k7 Map3k8 Map3k8 Eras Eras Malt1 Malt1 Cdc42 Cdc42 Ppp3cb Ppp3cb Nfkbia Nfkbia Mapk8 Mapk8 Map3k14 Map3k14 Pik3cb Pik3cb Jun Jun Cd3d Cd3d Pdpk1 Pdpk1 Fyn Fyn Pik3r1 Pik3r1 Grap2 Grap2 Vav3 Vav3 Cd3g Cd3g Ikbkg Ikbkg Cd4 Cd4 Pak3 Pak3 Il10 Il10 Pak6 Pak6 Csf2 Csf2 Il4 Il4 Il5 Il5 Cd3e Cd3e ENSMAUP00000008458 ENSMAUP00000008458 Vav2 Vav2 Cdk4 Cdk4 Pak1 Pak1 Hck Hck Bcl10 Bcl10 Map2k1 Map2k1 Rhoc Rhoc Map2k2 Map2k2 Nfatc2 Nfatc2 Pak5 Pak5 Lat Lat Nfkbie Nfkbie Mapk3 Mapk3 Ppp3ca Ppp3ca Akt1 Akt1 Sos2 Sos2 Nfatc1 Nfatc1 Ifng Ifng Lck Lck Csde1 Csde1 ENSMAUP00000014320 ENSMAUP00000014320 Tnf Tnf ENSMAUP00000014844 ENSMAUP00000014844 Ppp3r1 Ppp3r1 Nfkbib Nfkbib Ikbkb Ikbkb Rhoa Rhoa Rela Rela Raf1 Raf1 Gsk3b Gsk3b Mapk14 Mapk14 ENSMAUP00000017208 ENSMAUP00000017208 Akt3 Akt3 4930544G11Rik 4930544G11Rik Map3k7 Map3k7 Pik3r2 Pik3r2 Grb2 Grb2 Mapk10 Mapk10 Mapk1 Mapk1 Il2 Il2 Mapk13 Mapk13 Mapk9 Mapk9 Chuk Chuk Ctla4 Ctla4 Kras Kras Srms Srms Lcp2 Lcp2 Nfkb1 Nfkb1 Nck2 Nck2 ENSMAUP00000020463 ENSMAUP00000020463 Card11 Card11 Itk Itk Zap70 Zap70 Icos Icos Prkcq Prkcq Fos Fos Nck1 Nck1 Pik3ca Pik3ca Cd40lg Cd40lg Nras Nras Hras Hras ENSMAUP00000022739 ENSMAUP00000022739 Cd28 Cd28 Cd247 Cd247 Ptprc Ptprc Pak4 Pak4 Akt2 Akt2 Pik3r2-2 Pik3r2-2 Vav1 Vav1 Ptk6 Ptk6 Pak2 Pak2 Mapk12 Mapk12 Mapk11 Mapk11 Cd8a Cd8a Sos1 Sos1 Ppp3cc Ppp3cc Pdcd1 Pdcd1 Plcg1 Plcg1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Rasgrp1RAS guanyl-releasing protein 1. (796 aa)
Ppp3r2Calcineurin subunit B type 2. (183 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (520 aa)
Map3k8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
ErasGTPase ERas. (228 aa)
Malt1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X2. (823 aa)
Cdc42Cell division control protein 42 homolog isoform X1. (191 aa)
Ppp3cbSerine/threonine-protein phosphatase. (483 aa)
NfkbiaNF-kappa-B inhibitor alpha. (314 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Map3k14Mitogen-activated protein kinase kinase kinase 14. (941 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
Cd3dT-cell surface glycoprotein CD3 delta chain precursor. (171 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X2. (559 aa)
FynTyrosine-protein kinase. (537 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Grap2GRB2-related adapter protein 2 isoform X1. (324 aa)
Vav3Guanine nucleotide exchange factor VAV3 isoform X1. (847 aa)
Cd3gT-cell surface glycoprotein CD3 gamma chain. (182 aa)
IkbkgNF-kappa-B essential modulator isoform X1. (412 aa)
Cd4T-cell surface glycoprotein CD4. (397 aa)
Pak3Non-specific serine/threonine protein kinase. (559 aa)
Il10Interleukin-10 isoform X1. (178 aa)
Pak6Non-specific serine/threonine protein kinase. (681 aa)
Csf2Granulocyte-macrophage colony-stimulating factor. (142 aa)
Il4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (147 aa)
Il5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (121 aa)
Cd3eT-cell surface glycoprotein CD3 epsilon chain. (188 aa)
ENSMAUP00000008458annotation not available (123 aa)
Vav2Guanine nucleotide exchange factor VAV2 isoform X2. (868 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Pak1P21 (RAC1) activated kinase 1. (490 aa)
HckTyrosine-protein kinase. (519 aa)
Bcl10B-cell lymphoma/leukemia 10. (232 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RhocRho-related GTP-binding protein RhoC. (193 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Nfatc2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (929 aa)
Pak5Non-specific serine/threonine protein kinase. (718 aa)
LatLinker for activation of T-cells family member 1 isoform X1. (241 aa)
NfkbieNF-kappa-B inhibitor epsilon. (362 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Ppp3caSerine/threonine-protein phosphatase. (521 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Sos2Son of sevenless homolog 2 isoform X1. (1308 aa)
Nfatc1Nuclear factor of activated T-cells, cytoplasmic 1. (898 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (174 aa)
LckTyrosine-protein kinase. (316 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
ENSMAUP00000014320annotation not available (157 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ENSMAUP00000014844annotation not available (634 aa)
Ppp3r1Protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I). (157 aa)
NfkbibNF-kappa-B inhibitor beta. (358 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (757 aa)
RhoaTransforming protein RhoA-like isoform X2. (141 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
Gsk3bGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (429 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
ENSMAUP00000017208annotation not available (174 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
4930544G11RikTransforming protein RhoA-like isoform X1. (193 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (497 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Il2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Ctla4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
KrasGTPase KRas isoform X3. (189 aa)
SrmsTyrosine-protein kinase. (507 aa)
Lcp2Lymphocyte cytosolic protein 2. (542 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Nck2Cytoplasmic protein. (330 aa)
ENSMAUP00000020463annotation not available (168 aa)
Card11Caspase recruitment domain-containing protein 11 isoform X1. (1154 aa)
ItkTyrosine-protein kinase. (619 aa)
Zap70Tyrosine-protein kinase. (617 aa)
IcosInducible T-cell costimulator. (220 aa)
PrkcqProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
Nck1Cytoplasmic protein. (364 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Cd40lgCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
ENSMAUP00000022739annotation not available (212 aa)
Cd28T-cell-specific surface glycoprotein CD28. (219 aa)
Cd247LOW QUALITY PROTEIN: T-cell surface glycoprotein CD3 zeta chain. (163 aa)
PtprcReceptor-type tyrosine-protein phosphatase C isoform X5. (962 aa)
Pak4Non-specific serine/threonine protein kinase. (592 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Vav1Proto-oncogene vav. (845 aa)
Ptk6Tyrosine-protein kinase. (451 aa)
Pak2Non-specific serine/threonine protein kinase. (501 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
Mapk11Mitogen-activated protein kinase. (355 aa)
Cd8aT-cell surface glycoprotein CD8 alpha chain. (239 aa)
Sos1Son of sevenless homolog 1. (1319 aa)
Ppp3ccSerine/threonine-protein phosphatase. (514 aa)
Pdcd1Programmed cell death protein 1. (288 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1293 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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