STRINGSTRING
Cdk2 Cdk2 Mapk13 Mapk13 Mapk9 Mapk9 Kras Kras LOC101832350 LOC101832350 Cpeb1 Cpeb1 Ccnb2 Ccnb2 Rps6ka1 Rps6ka1 Anapc5 Anapc5 Ccna2 Ccna2 Anapc1 Anapc1 Ins Ins Hsp90ab1 Hsp90ab1 Pgr Pgr Anapc11 Anapc11 Ptrhd1 Ptrhd1 Adcy3 Adcy3 Cdc26 Cdc26 Pik3ca Pik3ca Nras Nras Aurkb Aurkb Mad2l2 Mad2l2 Cdk1 Cdk1 Anapc7 Anapc7 Cdc23 Cdc23 Igf1 Igf1 Akt2 Akt2 Pik3r2-2 Pik3r2-2 ENSMAUP00000024812 ENSMAUP00000024812 Cdc25c Cdc25c Mapk12 Mapk12 ENSMAUP00000025679 ENSMAUP00000025679 Mapk11 Mapk11 Mapk1 Mapk1 Mapk10 Mapk10 Pik3r2 Pik3r2 Mos Mos Akt3 Akt3 LOC101837857 LOC101837857 Braf Braf Adcy9 Adcy9 Mapk14 Mapk14 Anapc4 Anapc4 ENSMAUP00000016715 ENSMAUP00000016715 Raf1 Raf1 Rps6ka3 Rps6ka3 Mad1l1 Mad1l1 Anapc10 Anapc10 Adcy8 Adcy8 Cdk3 Cdk3 Adcy2 Adcy2 LOC101843422 LOC101843422 Bub1 Bub1 Cdc27 Cdc27 Cdc25b Cdc25b Plk1 Plk1 Ccna1 Ccna1 Akt1 Akt1 ENSMAUP00000012811 ENSMAUP00000012811 Gnai2 Gnai2 Cpeb2 Cpeb2 Aurkc Aurkc Mad2l1 Mad2l1 Mapk3 Mapk3 Adcy1 Adcy1 Adcy5 Adcy5 Anapc2 Anapc2 Map2k1 Map2k1 Adcy6 Adcy6 ENSMAUP00000010462 ENSMAUP00000010462 Cpeb4 Cpeb4 Igf1r Igf1r Kif22 Kif22 Ap5s1 Ap5s1 Araf Araf ENSMAUP00000008492 ENSMAUP00000008492 Aurka Aurka Pik3r1 Pik3r1 Gnai3 Gnai3 Tmem82 Tmem82 Rrad Rrad Pik3cb Pik3cb Gem Gem Mapk8 Mapk8 ENSMAUP00000004541 ENSMAUP00000004541 Adcy7 Adcy7 ENSMAUP00000004398 ENSMAUP00000004398 Stk10 Stk10 Rem1 Rem1 Prkaca Prkaca Pkmyt1 Pkmyt1 Ccnb3 Ccnb3 Anapc13 Anapc13 Spdya Spdya Prkacb Prkacb Cpeb3 Cpeb3 LOC101831400 LOC101831400 Rps6ka2 Rps6ka2 Ccnb1 Ccnb1 Rps6ka6 Rps6ka6 Pik3cd Pik3cd Cdc16 Cdc16 Adcy4 Adcy4 ENSMAUP00000001261 ENSMAUP00000001261 Fzr1 Fzr1 Gnai1 Gnai1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cdk2Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
KrasGTPase KRas isoform X3. (189 aa)
LOC101832350Aurora kinase C-like. (108 aa)
Cpeb1Cytoplasmic polyadenylation element-binding protein 1 isoform X2. (551 aa)
Ccnb2G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (384 aa)
Rps6ka1Ribosomal protein S6 kinase. (743 aa)
Anapc5Anaphase-promoting complex subunit 5. (84 aa)
Ccna2Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. (421 aa)
Anapc1Anaphase-promoting complex subunit 1. (1666 aa)
InsInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
Hsp90ab1Heat shock protein HSP 90-beta. (724 aa)
PgrProgesterone receptor. (927 aa)
Anapc11Anaphase-promoting complex subunit 11. (47 aa)
Ptrhd1LOW QUALITY PROTEIN: putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
Cdc26Anaphase-promoting complex subunit CDC26. (85 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
AurkbAurora kinase B isoform X1; Belongs to the protein kinase superfamily. (339 aa)
Mad2l2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
Cdk1Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (297 aa)
Anapc7Anaphase-promoting complex subunit 7. (540 aa)
Cdc23Cell division cycle protein 23 homolog. (580 aa)
Igf1Insulin-like growth factor 1. (153 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
ENSMAUP00000024812annotation not available (115 aa)
Cdc25cCell division cycle 25C. (271 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
ENSMAUP00000025679annotation not available (108 aa)
Mapk11Mitogen-activated protein kinase. (355 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
MosProto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (357 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC101837857Cell division cycle protein 27 homolog. (204 aa)
BrafSerine/threonine-protein kinase B-raf. (710 aa)
Adcy9Adenylate cyclase type 9 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (812 aa)
ENSMAUP00000016715annotation not available (418 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
Rps6ka3Ribosomal protein S6 kinase. (740 aa)
Mad1l1Mitotic spindle assembly checkpoint protein MAD1-like. (717 aa)
Anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
Cdk3Cyclin-dependent kinase 3 isoform X2; Belongs to the protein kinase superfamily. (297 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
LOC101843422Speedy protein E4A-like. (265 aa)
Bub1Mitotic checkpoint serine/threonine-protein kinase BUB1. (1012 aa)
Cdc27Cell division cycle protein 27 homolog. (680 aa)
Cdc25bM-phase inducer phosphatase 2. (575 aa)
Plk1Serine/threonine-protein kinase PLK. (602 aa)
Ccna1cyclin-A1; Belongs to the cyclin family. (421 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSMAUP00000012811annotation not available (405 aa)
Gnai2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
Cpeb2Cytoplasmic polyadenylation element-binding protein 2 isoform X2. (588 aa)
AurkcAurora kinase C. (118 aa)
Mad2l1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1118 aa)
Adcy5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
Anapc2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (833 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
ENSMAUP00000010462annotation not available (108 aa)
Cpeb4Cytoplasmic polyadenylation element-binding protein 4 isoform X1. (729 aa)
Igf1rTyrosine-protein kinase receptor. (1154 aa)
Kif22Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (656 aa)
Ap5s1AP-5 complex subunit sigma-1. (59 aa)
ArafSerine/threonine-protein kinase A-Raf isoform X2. (604 aa)
ENSMAUP00000008492annotation not available (391 aa)
AurkaAurora kinase A; Belongs to the protein kinase superfamily. (401 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Gnai3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
Tmem82Transmembrane protein 82. (356 aa)
RradGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (307 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GemGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
ENSMAUP00000004541annotation not available (622 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
ENSMAUP00000004398annotation not available (164 aa)
Stk10Serine/threonine-protein kinase 10. (831 aa)
Rem1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (297 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Pkmyt1Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Belongs to the protein kinase superfamily. (490 aa)
Ccnb3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1356 aa)
Anapc13Anaphase-promoting complex subunit 13. (74 aa)
SpdyaSpeedy protein A. (183 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
Cpeb3Cytoplasmic polyadenylation element-binding protein 3 isoform X1. (720 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
Rps6ka2Ribosomal protein S6 kinase. (733 aa)
Ccnb1G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (447 aa)
Rps6ka6Ribosomal protein S6 kinase. (861 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Cdc16Cell division cycle protein 16 homolog isoform X1. (620 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
ENSMAUP00000001261annotation not available (61 aa)
Fzr1Fizzy-related protein homolog. (493 aa)
Gnai1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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