STRINGSTRING
Mapk1 Mapk1 Kras Kras Ncoa2 Ncoa2 Krt18 Krt18 Tgfa Tgfa Kcnj3 Kcnj3 Creb1 Creb1 Atf2 Atf2 Sp1 Sp1 Hsp90ab1 Hsp90ab1 Gnas Gnas Adcy2 Adcy2 Ifitm10 Ifitm10 LOC101827846 LOC101827846 Pgr Pgr Ptrhd1 Ptrhd1 Esr2 Esr2 Krt40 Krt40 Adcy3 Adcy3 Calm2 Calm2 Fos Fos Hsp90b1 Hsp90b1 Fkbp5 Fkbp5 Pik3ca Pik3ca Shc1 Shc1 Nras Nras Tff1 Tff1 Hras Hras Itpr3 Itpr3 Ctsd Ctsd Akt2 Akt2 Creb3l3 Creb3l3 Shc4 Shc4 Pik3r2-2 Pik3r2-2 Prkcd Prkcd ENSMAUP00000024871 ENSMAUP00000024871 Krt12 Krt12 LOC110341725 LOC110341725 ENSMAUP00000025153 ENSMAUP00000025153 Krt10 Krt10 ENSMAUP00000025679 ENSMAUP00000025679 Calm1 Calm1 Itpr1 Itpr1 Grb2 Grb2 Nos3 Nos3 Pik3r2 Pik3r2 Ncoa1 Ncoa1 Oprm1 Oprm1 Akt3 Akt3 Krt25 Krt25 Krt28 Krt28 Krt13 Krt13 Adcy9 Adcy9 Krt23 Krt23 Krt17 Krt17 Raf1 Raf1 Hspa1l Hspa1l Plcb1 Plcb1 Calml4 Calml4 Atf6b Atf6b Krt36 Krt36 Krt14 Krt14 Rara Rara Adcy8 Adcy8 Ebag9 Ebag9 Sos1 Sos1 Gnao1 Gnao1 Egfr Egfr Gnai1 Gnai1 Krt24 Krt24 Adcy4 Adcy4 ENSMAUP00000001411 ENSMAUP00000001411 Hbegf Hbegf ENSMAUP00000001676 ENSMAUP00000001676 Krt19 Krt19 Pik3cd Pik3cd LOC101831400 LOC101831400 Prkacb Prkacb ENSMAUP00000003031 ENSMAUP00000003031 Creb3l1 Creb3l1 Grm1 Grm1 Eras Eras Hspa2 Hspa2 Kcnj9 Kcnj9 Calml3 Calml3 Prkaca Prkaca Adcy7 Adcy7 Mmp9 Mmp9 ENSMAUP00000004541 ENSMAUP00000004541 LOC101840621 LOC101840621 Plcb2 Plcb2 Esr1 Esr1 Pik3cb Pik3cb Jun Jun LOC101826865 LOC101826865 Gabbr2 Gabbr2 Pomc Pomc Shc2 Shc2 ENSMAUP00000006097 ENSMAUP00000006097 Gnai3 Gnai3 Pik3r1 Pik3r1 Fkbp4 Fkbp4 Creb3l2 Creb3l2 Ccdc170 Ccdc170 Creb5 Creb5 LOC101827825 LOC101827825 Krt26 Krt26 ENSMAUP00000008492 ENSMAUP00000008492 Src Src LOC106022660 LOC106022660 Shc3 Shc3 Mmp2 Mmp2 Ncoa3 Ncoa3 Krt27 Krt27 Bcl2 Bcl2 Adcy6 Adcy6 Map2k1 Map2k1 Krt32 Krt32 Adcy5 Adcy5 Kcnj6 Kcnj6 Kcnj5 Kcnj5 Calm3 Calm3 Krt39 Krt39 Map2k2 Map2k2 Adcy1 Adcy1 Krt34 Krt34 Atf4 Atf4 Mapk3 Mapk3 Krt15 Krt15 Gnai2 Gnai2 Plcb4 Plcb4 Hspa8 Hspa8 Krt20 Krt20 Itpr2 Itpr2 Gabbr1 Gabbr1 Creb3 Creb3 Akt1 Akt1 Sos2 Sos2 Krt16 Krt16 Gper1 Gper1 Cep152 Cep152 Krt35 Krt35 LOC101834284 LOC101834284 Csde1 Csde1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
KrasGTPase KRas isoform X3. (189 aa)
Ncoa2Nuclear receptor coactivator. (1475 aa)
Krt18Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (425 aa)
TgfaProtransforming growth factor alpha. (159 aa)
Kcnj3LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 1. (194 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (480 aa)
Sp1Transcription factor Sp1 isoform X1. (786 aa)
Hsp90ab1Heat shock protein HSP 90-beta. (724 aa)
GnasGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (394 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
Ifitm10Interferon-induced transmembrane protein 10. (199 aa)
LOC101827846Coiled-coil domain-containing protein 170-like. (352 aa)
PgrProgesterone receptor. (927 aa)
Ptrhd1LOW QUALITY PROTEIN: putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
Esr2Estrogen receptor beta. (305 aa)
Krt40Keratin, type I cytoskeletal 40 isoform X1; Belongs to the intermediate filament family. (431 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
Calm2Calmodulin 2. (149 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
Hsp90b1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (802 aa)
Fkbp5Peptidylprolyl isomerase. (456 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Shc1SHC-transforming protein 1 isoform X1. (579 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
Tff1Trefoil factor 1. (81 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
Itpr3Inositol 1,4,5-trisphosphate receptor type 3. (2660 aa)
CtsdCathepsin D; Belongs to the peptidase A1 family. (410 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Creb3l3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1. (475 aa)
Shc4SHC adaptor protein 4. (204 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
PrkcdProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
ENSMAUP00000024871annotation not available (380 aa)
Krt12Keratin, type I cytoskeletal 12; Belongs to the intermediate filament family. (483 aa)
LOC110341725Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (854 aa)
ENSMAUP00000025153annotation not available (525 aa)
Krt10Keratin, type I cytoskeletal 10 isoform X2; Belongs to the intermediate filament family. (564 aa)
ENSMAUP00000025679annotation not available (108 aa)
Calm1Calmodulin 1. (149 aa)
Itpr1Inositol 1,4,5-trisphosphate receptor type 1 isoform X2. (2757 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Ncoa1Nuclear receptor coactivator. (1444 aa)
Oprm1Mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (398 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Krt25Keratin, type I cytoskeletal 25; Belongs to the intermediate filament family. (446 aa)
Krt28Keratin, type I cytoskeletal 28; Belongs to the intermediate filament family. (462 aa)
Krt13Keratin, type I cytoskeletal 13; Belongs to the intermediate filament family. (440 aa)
Adcy9Adenylate cyclase type 9 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
Krt23Keratin, type I cytoskeletal 23; Belongs to the intermediate filament family. (423 aa)
Krt17Keratin, type I cytoskeletal 17; Belongs to the intermediate filament family. (433 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
Hspa1lHeat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (629 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
Calml4Calmodulin-like protein 4 isoform X2. (141 aa)
Atf6bCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (73 aa)
Krt36Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. (467 aa)
Krt14Keratin, type I cytoskeletal 14; Belongs to the intermediate filament family. (467 aa)
RaraRetinoic acid receptor alpha isoform X1. (462 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
Ebag9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
Sos1Son of sevenless homolog 1. (1319 aa)
Gnao1Guanine nucleotide-binding protein G(O) subunit alpha isoform X2. (354 aa)
EgfrReceptor protein-tyrosine kinase. (1207 aa)
Gnai1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
Krt24Keratin, type I cytoskeletal 24; Belongs to the intermediate filament family. (520 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
ENSMAUP00000001411annotation not available (387 aa)
HbegfProheparin-binding EGF-like growth factor. (202 aa)
ENSMAUP00000001676annotation not available (191 aa)
Krt19Keratin, type I cytoskeletal 19 isoform X1; Belongs to the intermediate filament family. (403 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
ENSMAUP00000003031annotation not available (117 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
Grm1Metabotropic glutamate receptor 1. (829 aa)
ErasGTPase ERas. (228 aa)
Hspa2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (633 aa)
Kcnj9G protein-activated inward rectifier potassium channel 3 isoform X1. (393 aa)
Calml3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
Mmp9Matrix metalloproteinase-9. (718 aa)
ENSMAUP00000004541annotation not available (622 aa)
LOC101840621G protein-activated inward rectifier potassium channel 1. (234 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
Esr1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
LOC101826865Cyclic AMP-responsive element-binding protein 3-like protein 4. (213 aa)
Gabbr2Gamma-aminobutyric acid type B receptor subunit 2. (808 aa)
PomcPro-opiomelanocortin. (234 aa)
Shc2SHC-transforming protein 2. (573 aa)
ENSMAUP00000006097annotation not available (76 aa)
Gnai3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Fkbp4Peptidylprolyl isomerase. (458 aa)
Creb3l2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2. (520 aa)
Ccdc170Coiled-coil domain-containing protein 170 isoform X1. (718 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X3. (508 aa)
LOC101827825Keratin, type I cytoskeletal 42 isoform X1; Belongs to the intermediate filament family. (224 aa)
Krt26Keratin, type I cytoskeletal 26; Belongs to the intermediate filament family. (464 aa)
ENSMAUP00000008492annotation not available (391 aa)
SrcTyrosine-protein kinase. (536 aa)
LOC106022660Keratin, type I cuticular Ha3-I; Belongs to the intermediate filament family. (344 aa)
Shc3SHC-transforming protein 3. (595 aa)
Mmp272 kDa type IV collagenase. (662 aa)
Ncoa3Nuclear receptor coactivator. (1409 aa)
Krt27Keratin, type I cytoskeletal 27; Belongs to the intermediate filament family. (447 aa)
Bcl2Apoptosis regulator Bcl-2. (236 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Krt32LOW QUALITY PROTEIN: keratin, type I cuticular Ha2; Belongs to the intermediate filament family. (407 aa)
Adcy5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
Kcnj6G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G- protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due t [...] (386 aa)
Kcnj5G protein-activated inward rectifier potassium channel 4. (343 aa)
Calm3Calmodulin-2 isoform X1; Belongs to the calmodulin family. (149 aa)
Krt39Keratin, type I cytoskeletal 39; Belongs to the intermediate filament family. (481 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1118 aa)
Krt34LOW QUALITY PROTEIN: keratin, type I cuticular Ha4; Belongs to the intermediate filament family. (419 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Krt15Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). Belongs to the intermediate filament family. (457 aa)
Gnai2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa)
Hspa8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (646 aa)
Krt20Keratin, type I cytoskeletal 20; Belongs to the intermediate filament family. (431 aa)
Itpr2Inositol 1,4,5-trisphosphate receptor type 2. (2584 aa)
Gabbr1Gamma-aminobutyric acid type B receptor subunit 1 isoform X1. (979 aa)
Creb3Cyclic AMP-responsive element-binding protein 3 isoform X1. (386 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Sos2Son of sevenless homolog 2 isoform X1. (1308 aa)
Krt16Keratin, type I cytoskeletal 16 isoform X2; Belongs to the intermediate filament family. (460 aa)
Gper1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
Cep152Centrosomal protein of 152 kDa. (1691 aa)
Krt35Keratin, type I cuticular Ha5; Belongs to the intermediate filament family. (455 aa)
LOC101834284Neuroendocrine secretory protein 55-like. (250 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (22%) [HD]