STRINGSTRING
Adcy6 Adcy6 Gm19410 Gm19410 Itpr2 Itpr2 LOC101823517 LOC101823517 Plcb4 Plcb4 Atf4 Atf4 Adcy1 Adcy1 Ttr Ttr Adcy5 Adcy5 Atp1b2 Atp1b2 Duox1 Duox1 LOC110341725 LOC110341725 Slc5a5 Slc5a5 Gpx2 Gpx2 Creb3l3 Creb3l3 Itpr3 Itpr3 Hsp90b1 Hsp90b1 Duoxa2 Duoxa2 Adcy3 Adcy3 Ptrhd1 Ptrhd1 Gnas Gnas Atf2 Atf2 Creb1 Creb1 Fxyd2 Fxyd2 Atp1b1 Atp1b1 Atp1a1 Atp1a1 Atp1b4 Atp1b4 Itpr1 Itpr1 Hspa5 Hspa5 Ttf2 Ttf2 Gpx7 Gpx7 Adcy9 Adcy9 Plcb1 Plcb1 Duox2 Duox2 Atf6b Atf6b Gpx6 Gpx6 Gpx1 Gpx1 Adcy8 Adcy8 Adcy2 Adcy2 LOC101834284 LOC101834284 Iyd Iyd Atp1a4 Atp1a4 Gsr Gsr Prkcb Prkcb Pdia4 Pdia4 Sycp1 Sycp1 Alb Alb Adcy4 Adcy4 Tpo Tpo Prkcg Prkcg Gpx3 Gpx3 ENSMAUP00000002714 ENSMAUP00000002714 Prkacb Prkacb Creb3 Creb3 Creb3l1 Creb3l1 Pax8 Pax8 Prkaca Prkaca Tshb Tshb Adcy7 Adcy7 Plcb2 Plcb2 Serpina7 Serpina7 LOC101826865 LOC101826865 Asgr1 Asgr1 Canx Canx Lrp2 Lrp2 Serpina9 Serpina9 Creb3l2 Creb3l2 Creb5 Creb5 Prkca Prkca Gpx8 Gpx8 Ttf1 Ttf1 Atp1a2 Atp1a2 Cga Cga Slc26a4 Slc26a4 Tshr Tshr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
Gm19410Very low-density lipoprotein receptor-like. (2095 aa)
Itpr2Inositol 1,4,5-trisphosphate receptor type 2. (2584 aa)
LOC101823517Glutathione peroxidase; Belongs to the glutathione peroxidase family. (192 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1118 aa)
TtrTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (147 aa)
Adcy5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
Atp1b2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
Duox1Dual oxidase 1. (1401 aa)
LOC110341725Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (854 aa)
Slc5a5Sodium/iodide cotransporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (618 aa)
Gpx2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
Creb3l3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1. (475 aa)
Itpr3Inositol 1,4,5-trisphosphate receptor type 3. (2660 aa)
Hsp90b1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (802 aa)
Duoxa2Dual oxidase maturation factor 2. (315 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
Ptrhd1LOW QUALITY PROTEIN: putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
GnasGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (394 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (480 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Fxyd2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
Atp1b1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
Atp1a1Sodium/potassium-transporting ATPase subunit alpha. (1019 aa)
Atp1b4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (355 aa)
Itpr1Inositol 1,4,5-trisphosphate receptor type 1 isoform X2. (2757 aa)
Hspa5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (656 aa)
Ttf2Transcription termination factor 2. (1116 aa)
Gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
Adcy9Adenylate cyclase type 9 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
Duox2Dual oxidase 2. (1306 aa)
Atf6bCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (73 aa)
Gpx6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
Gpx1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (200 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
LOC101834284Neuroendocrine secretory protein 55-like. (250 aa)
IydIodotyrosine deiodinase 1. (286 aa)
Atp1a4Sodium/potassium-transporting ATPase subunit alpha. (937 aa)
GsrGlutathione-disulfide reductase. (323 aa)
PrkcbProtein kinase C beta. (554 aa)
Pdia4Protein disulfide-isomerase A4. (643 aa)
Sycp1Synaptonemal complex protein 1; Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (By similarity). Has non-specific DNA binding capability. (896 aa)
AlbSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (530 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
TpoThyroid peroxidase. (914 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (612 aa)
Gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
ENSMAUP00000002714annotation not available (58 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
Creb3Cyclic AMP-responsive element-binding protein 3 isoform X1. (386 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
Pax8Paired box protein Pax-8 isoform X2. (457 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
TshbThyrotropin subunit beta. (138 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
Serpina7LOW QUALITY PROTEIN: thyroxine-binding globulin; Belongs to the serpin family. (367 aa)
LOC101826865Cyclic AMP-responsive element-binding protein 3-like protein 4. (213 aa)
Asgr1Asialoglycoprotein receptor 1. (285 aa)
CanxCalnexin isoform X1. (592 aa)
Lrp2Low-density lipoprotein receptor-related protein 2. (4244 aa)
Serpina9Serpin A9; Belongs to the serpin family. (419 aa)
Creb3l2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2. (520 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X3. (508 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
Gpx8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
Ttf1Transcription termination factor 1 isoform X1. (825 aa)
Atp1a2Sodium/potassium-transporting ATPase subunit alpha. (918 aa)
CgaGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (120 aa)
Slc26a4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (780 aa)
TshrThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (738 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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