STRINGSTRING
Arrb1 Arrb1 LOC110341725 LOC110341725 Col4a1 Col4a1 Pik3r2-2 Pik3r2-2 Gng2 Gng2 Shc4 Shc4 Creb3l3 Creb3l3 Akt2 Akt2 Col4a3 Col4a3 Gng11 Gng11 Col4a2 Col4a2 Hras Hras Nras Nras Shc1 Shc1 Pik3ca Pik3ca Col4a4 Col4a4 ENSMAUP00000021947 ENSMAUP00000021947 Fos Fos Adcy3 Adcy3 Col1a1 Col1a1 Ptrhd1 Ptrhd1 Gngt2 Gngt2 ENSMAUP00000021163 ENSMAUP00000021163 Gnas Gnas Col1a2 Col1a2 Fbxo21 Fbxo21 Gm4356 Gm4356 Atf2 Atf2 Creb1 Creb1 Nfkb1 Nfkb1 Rxfp2 Rxfp2 Kras Kras Mapk9 Mapk9 Mapk13 Mapk13 Mapk1 Mapk1 Mapk10 Mapk10 Grb2 Grb2 Nos3 Nos3 Nos1 Nos1 Pik3r2 Pik3r2 Gng10 Gng10 Gna15 Gna15 Nos2 Nos2 Prkcz Prkcz Akt3 Akt3 Rln3 Rln3 Edn1 Edn1 Vegfd Vegfd Adcy9 Adcy9 Mapk14 Mapk14 Gng12 Gng12 Raf1 Raf1 Rela Rela Plcb1 Plcb1 Atf6b Atf6b Ednrb Ednrb Adcy8 Adcy8 ENSMAUP00000014436 ENSMAUP00000014436 Adcy2 Adcy2 Csde1 Csde1 LOC101834284 LOC101834284 Vegfb Vegfb Cep152 Cep152 Arrb2 Arrb2 Tgfbr1 Tgfbr1 Sos2 Sos2 Akt1 Akt1 Creb3 Creb3 Plcb4 Plcb4 Gnai2 Gnai2 Gng3 Gng3 ENSMAUP00000012091 ENSMAUP00000012091 Mapk3 Mapk3 Atf4 Atf4 Rxfp1 Rxfp1 Adcy1 Adcy1 Map2k2 Map2k2 ENSMAUP00000010921 ENSMAUP00000010921 Gnb4 Gnb4 Adcy5 Adcy5 Map2k1 Map2k1 Adcy6 Adcy6 Col4a5 Col4a5 Gng4 Gng4 Gnb2 Gnb2 Mmp2 Mmp2 Shc3 Shc3 Col3a1 Col3a1 Gng13 Gng13 LOC101824185 LOC101824185 Src Src Gng7 Gng7 Gnb3 Gnb3 Creb5 Creb5 Rln1 Rln1 Gnb5 Gnb5 Creb3l2 Creb3l2 Insl3 Insl3 Pik3r1 Pik3r1 Gnai3 Gnai3 Wdr78 Wdr78 Shc2 Shc2 Vegfa Vegfa LOC101826865 LOC101826865 Acta2 Acta2 Jun Jun Pik3cb Pik3cb Smad2 Smad2 Plcb2 Plcb2 Mapk8 Mapk8 Rxfp3 Rxfp3 Nfkbia Nfkbia Mmp9 Mmp9 Adcy7 Adcy7 Prkaca Prkaca Eras Eras Tgfb1 Tgfb1 Map2k7 Map2k7 Creb3l1 Creb3l1 Prkacb Prkacb Insl5 Insl5 Sos1 Sos1 Gng8 Gng8 Gnao1 Gnao1 Egfr Egfr Gnai1 Gnai1 Adcy4 Adcy4 Gng14 Gng14 Mmp13 Mmp13 Pik3cd Pik3cd Col4a6 Col4a6 Gngt1 Gngt1 Tgfbr2 Tgfbr2 LOC101831400 LOC101831400 Vegfc Vegfc Mapk11 Mapk11 Mapk12 Mapk12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Arrb1Beta-arrestin-1 isoform X3. (418 aa)
LOC110341725Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (854 aa)
Col4a1Collagen type IV alpha 1 chain. (1538 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Gng2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
Shc4SHC adaptor protein 4. (204 aa)
Creb3l3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1. (475 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Col4a3Collagen alpha-3(IV) chain. (1621 aa)
Gng11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
Col4a2Collagen type IV alpha 2 chain. (1472 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
Shc1SHC-transforming protein 1 isoform X1. (579 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Col4a4Collagen alpha-4(IV) chain. (157 aa)
ENSMAUP00000021947annotation not available (57 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
Col1a1Collagen alpha-1(I) chain isoform X1. (1453 aa)
Ptrhd1LOW QUALITY PROTEIN: putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
Gngt2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
ENSMAUP00000021163annotation not available (137 aa)
GnasGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (394 aa)
Col1a2Collagen alpha-2(I) chain. (1372 aa)
Fbxo21F-box only protein 21 isoform X1. (627 aa)
Gm4356Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (480 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Rxfp2Relaxin receptor 2. (758 aa)
KrasGTPase KRas isoform X3. (189 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (80 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
Gna15Guanine nucleotide-binding protein subunit alpha-15 isoform X1. (374 aa)
Nos2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
PrkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Rln3Relaxin-3. (140 aa)
Edn1Endothelin-1. (202 aa)
VegfdVascular endothelial growth factor D isoform X3; Belongs to the PDGF/VEGF growth factor family. (358 aa)
Adcy9Adenylate cyclase type 9 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Gng12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (50 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
Atf6bCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (73 aa)
EdnrbEndothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (432 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
ENSMAUP00000014436annotation not available (114 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
LOC101834284Neuroendocrine secretory protein 55-like. (250 aa)
VegfbVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (201 aa)
Cep152Centrosomal protein of 152 kDa. (1691 aa)
Arrb2Beta-arrestin-2. (279 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
Sos2Son of sevenless homolog 2 isoform X1. (1308 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Creb3Cyclic AMP-responsive element-binding protein 3 isoform X1. (386 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa)
Gnai2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
Gng3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSMAUP00000012091annotation not available (86 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
Rxfp1Relaxin receptor 1. (751 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1118 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ENSMAUP00000010921annotation not available (677 aa)
Gnb4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
Adcy5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
Col4a5Collagen alpha-5(IV) chain isoform X2. (438 aa)
Gng4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
Gnb2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (382 aa)
Mmp272 kDa type IV collagenase. (662 aa)
Shc3SHC-transforming protein 3. (595 aa)
Col3a1Collagen alpha-1(III) chain. (1465 aa)
Gng13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
LOC101824185Interstitial collagenase A. (465 aa)
SrcTyrosine-protein kinase. (536 aa)
Gng7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
Gnb3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X3. (508 aa)
Rln1Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. It bears mature young, and allows separation of the pelvic bones. (177 aa)
Gnb5Guanine nucleotide-binding protein subunit beta-5. (388 aa)
Creb3l2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2. (520 aa)
Insl3Insulin-like 3. (125 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Gnai3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
Wdr78WD repeat-containing protein 78. (788 aa)
Shc2SHC-transforming protein 2. (573 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (248 aa)
LOC101826865Cyclic AMP-responsive element-binding protein 3-like protein 4. (213 aa)
Acta2Actin, aortic smooth muscle. (377 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Rxfp3Relaxin-3 receptor 1. (477 aa)
NfkbiaNF-kappa-B inhibitor alpha. (314 aa)
Mmp9Matrix metalloproteinase-9. (718 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
ErasGTPase ERas. (228 aa)
Tgfb1Transforming growth factor beta-1. (286 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (520 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
Insl5Insulin-like 5. (145 aa)
Sos1Son of sevenless homolog 1. (1319 aa)
Gng8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
Gnao1Guanine nucleotide-binding protein G(O) subunit alpha isoform X2. (354 aa)
EgfrReceptor protein-tyrosine kinase. (1207 aa)
Gnai1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
Mmp13Collagenase 3. (471 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Col4a6Collagen alpha-6(IV) chain. (1691 aa)
Gngt1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
VegfcVascular endothelial growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (415 aa)
Mapk11Mitogen-activated protein kinase. (355 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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