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Itpr3 Itpr3 Cacna1d Cacna1d Creb3l3 Creb3l3 Cacna1f Cacna1f LOC110341725 LOC110341725 Kcna4 Kcna4 Prkacb Prkacb Adcy4 Adcy4 Pbx4 Pbx4 Nr0b1 Nr0b1 Nceh1 Nceh1 Creb3l1 Creb3l1 Gna11 Gna11 Kcnk2 Kcnk2 Cacna1s Cacna1s Prkaca Prkaca Adcy7 Adcy7 Plcb2 Plcb2 LOC101826865 LOC101826865 Pomc Pomc Creb3l2 Creb3l2 Creb5 Creb5 Scarb1 Scarb1 Cacna1i Cacna1i Gnaq Gnaq Kcna5 Kcna5 Agtr1 Agtr1 Nr5a1 Nr5a1 Kcna1 Kcna1 Adcy6 Adcy6 Adcy5 Adcy5 Adcy1 Adcy1 Atf4 Atf4 LOC101827747 LOC101827747 LOC101823339 LOC101823339 Plcb4 Plcb4 Itpr2 Itpr2 Creb3 Creb3 Pde8a Pde8a LOC101837099 LOC101837099 Cyp21a1 Cyp21a1 Nr4a1 Nr4a1 LOC101834284 LOC101834284 Adcy2 Adcy2 Adcy8 Adcy8 Atf6b Atf6b Plcb1 Plcb1 Cyp17a1 Cyp17a1 Kcna3 Kcna3 Cacna1g Cacna1g Pde8b Pde8b Adcy9 Adcy9 Orai1 Orai1 Kcna2 Kcna2 Kcnk3 Kcnk3 Mc2r Mc2r Itpr1 Itpr1 LOC101840244 LOC101840244 Star Star Cacna1h Cacna1h Cacna1c Cacna1c Kcna10 Kcna10 Creb1 Creb1 Ldlr Ldlr Atf2 Atf2 Sp1 Sp1 Agt Agt Gnas Gnas Ptrhd1 Ptrhd1 Adcy3 Adcy3 Pbx1 Pbx1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Itpr3Inositol 1,4,5-trisphosphate receptor type 3. (2660 aa)
Cacna1dVoltage-dependent L-type calcium channel subunit alpha-1D; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines; B [...] (1378 aa)
Creb3l3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1. (475 aa)
Cacna1fVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1979 aa)
LOC110341725Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (854 aa)
Kcna4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (654 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
Pbx4pre-B-cell leukemia transcription factor 4 isoform X5. (380 aa)
Nr0b1Nuclear receptor subfamily 0 group B member 1. (476 aa)
Nceh1Neutral cholesterol ester hydrolase 1. (408 aa)
Creb3l1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
Gna11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
Kcnk2Potassium channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
Cacna1sVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
LOC101826865Cyclic AMP-responsive element-binding protein 3-like protein 4. (213 aa)
PomcPro-opiomelanocortin. (234 aa)
Creb3l2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2. (520 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X3. (508 aa)
Scarb1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (509 aa)
Cacna1iVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2197 aa)
GnaqGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
Kcna5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (539 aa)
Agtr1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Nr5a1Steroidogenic factor 1. (252 aa)
Kcna1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
Adcy5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1118 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
LOC101827747Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
LOC101823339Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (319 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa)
Itpr2Inositol 1,4,5-trisphosphate receptor type 2. (2584 aa)
Creb3Cyclic AMP-responsive element-binding protein 3 isoform X1. (386 aa)
Pde8aPhosphodiesterase. (825 aa)
LOC101837099NADPH-dependent 3-keto-steroid reductase HSD3B3; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. Belongs to the 3-beta-HSD family. (373 aa)
Cyp21a1Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. (496 aa)
Nr4a1Nuclear receptor subfamily 4 group A member 1. (600 aa)
LOC101834284Neuroendocrine secretory protein 55-like. (250 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
Atf6bCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (73 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
Cyp17a1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (431 aa)
Kcna3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (533 aa)
Cacna1gVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (385 aa)
Pde8bPhosphodiesterase. (885 aa)
Adcy9Adenylate cyclase type 9 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
Orai1Calcium release-activated calcium channel protein 1. (302 aa)
Kcna2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
Kcnk3Potassium channel subfamily K member. (407 aa)
Mc2rAdrenocorticotropic hormone receptor; Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). (297 aa)
Itpr1Inositol 1,4,5-trisphosphate receptor type 1 isoform X2. (2757 aa)
LOC101840244type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
StarSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (284 aa)
Cacna1hVoltage-dependent T-type calcium channel subunit alpha-1H isoform X3. (147 aa)
Cacna1cVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
Kcna10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (508 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
LdlrLow-density lipoprotein receptor isoform X1. (856 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (480 aa)
Sp1Transcription factor Sp1 isoform X1. (786 aa)
AgtAngiotensinogen; Belongs to the serpin family. (482 aa)
GnasGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (394 aa)
Ptrhd1LOW QUALITY PROTEIN: putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
Pbx1pre-B-cell leukemia transcription factor 1 isoform X1. (430 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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