STRINGSTRING
Mapk11 Mapk11 Pik3r2 Pik3r2 Nos3 Nos3 Mapk10 Mapk10 Mapk1 Mapk1 Mapk13 Mapk13 Mapk9 Mapk9 Kras Kras LOC101840244 LOC101840244 Il1b Il1b Il6 Il6 Rac1 Rac1 Ccnd1 Ccnd1 Nox1 Nox1 Nfkb1 Nfkb1 Cdkn1b Cdkn1b Il1a Il1a Col1a2 Col1a2 Agt Agt Xk Xk ENSMAUP00000021163 ENSMAUP00000021163 Col1a1 Col1a1 Col4a4 Col4a4 Pik3ca Pik3ca Nras Nras Hras Hras Col4a2 Col4a2 Prkcz Prkcz Akt3 Akt3 Edn1 Edn1 Vegfd Vegfd Mapk14 Mapk14 Rela Rela Bax Bax Plcb1 Plcb1 Stat1 Stat1 Tnf Tnf Csde1 Csde1 Nox3 Nox3 Vegfb Vegfb Diaph1 Diaph1 Nfatc1 Nfatc1 Tgfbr1 Tgfbr1 Ccl12 Ccl12 Prkcb Prkcb Akt1 Akt1 Plcb4 Plcb4 LOC110339561 LOC110339561 Mapk3 Mapk3 LOC101834491 LOC101834491 ENSMAUP00000010921 ENSMAUP00000010921 Col4a5 Col4a5 Agtr1 Agtr1 Bcl2 Bcl2 Cdk4 Cdk4 Mmp2 Mmp2 Col3a1 Col3a1 Tgfb2 Tgfb2 LOC101836961 LOC101836961 F3 F3 Smad4 Smad4 Prkca Prkca Stat3 Stat3 Plcd1 Plcd1 Jak2 Jak2 Pik3r1 Pik3r1 Plcg2 Plcg2 Egr1 Egr1 Vegfa Vegfa Jun Jun Pik3cb Pik3cb Smad2 Smad2 Plcb2 Plcb2 Mapk8 Mapk8 Icam1 Icam1 LOC101842510 LOC101842510 Tgfb3 Tgfb3 Casp3 Casp3 Cdc42 Cdc42 Eras Eras Vcam1 Vcam1 Tgfb1 Tgfb1 Plce1 Plce1 Serpine1 Serpine1 LOC101831400 LOC101831400 ENSMAUP00000002714 ENSMAUP00000002714 Dhdh Dhdh Tgfbr2 Tgfbr2 Col4a6 Col4a6 Fn1 Fn1 LOC101835654 LOC101835654 Pik3cd Pik3cd Plcg1 Plcg1 Nox4 Nox4 Plcd3 Plcd3 Plcd4 Plcd4 Ager Ager LOC101836687 LOC101836687 Prkce Prkce Foxo1 Foxo1 Sele Sele Ccl2 Ccl2 Col4a3 Col4a3 Akt2 Akt2 Pik3r2-2 Pik3r2-2 Col4a1 Col4a1 Prkcd Prkcd Mapk12 Mapk12 Vegfc Vegfc Smad3 Smad3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mapk11Mitogen-activated protein kinase. (355 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
KrasGTPase KRas isoform X3. (189 aa)
LOC101840244type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Il6Interleukin-6. (212 aa)
Rac1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Nox1NADPH oxidase 1. (587 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (198 aa)
Il1aInterleukin-1; Belongs to the IL-1 family. (269 aa)
Col1a2Collagen alpha-2(I) chain. (1372 aa)
AgtAngiotensinogen; Belongs to the serpin family. (482 aa)
XkXK-related protein. (449 aa)
ENSMAUP00000021163annotation not available (137 aa)
Col1a1Collagen alpha-1(I) chain isoform X1. (1453 aa)
Col4a4Collagen alpha-4(IV) chain. (157 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
Col4a2Collagen type IV alpha 2 chain. (1472 aa)
PrkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Edn1Endothelin-1. (202 aa)
VegfdVascular endothelial growth factor D isoform X3; Belongs to the PDGF/VEGF growth factor family. (358 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
BaxApoptosis regulator BAX isoform X1. (192 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
Nox3NADPH oxidase 3. (565 aa)
VegfbVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (201 aa)
Diaph1Protein diaphanous homolog 1 isoform X1. (397 aa)
Nfatc1Nuclear factor of activated T-cells, cytoplasmic 1. (898 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
Ccl12C-C motif chemokine. (105 aa)
PrkcbProtein kinase C beta. (554 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa)
LOC110339561Signal transducer and activator of transcription 5B-like. (125 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
LOC101834491Cytochrome b-245 heavy chain. (93 aa)
ENSMAUP00000010921annotation not available (677 aa)
Col4a5Collagen alpha-5(IV) chain isoform X2. (438 aa)
Agtr1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Bcl2Apoptosis regulator Bcl-2. (236 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Mmp272 kDa type IV collagenase. (662 aa)
Col3a1Collagen alpha-1(III) chain. (1465 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC101836961Serine/threonine-protein kinase pim-1. (313 aa)
F3Tissue factor. (248 aa)
Smad4Mothers against decapentaplegic homolog. (552 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
Stat3Signal transducer and activator of transcription. (758 aa)
Plcd1Phosphoinositide phospholipase C. (744 aa)
Jak2Tyrosine-protein kinase. (1132 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (533 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (248 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Icam1Intercellular adhesion molecule 1 isoform X2. (516 aa)
LOC101842510Signal transducer and activator of transcription 5A. (228 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Casp3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (246 aa)
Cdc42Cell division control protein 42 homolog isoform X1. (191 aa)
ErasGTPase ERas. (228 aa)
Vcam1Vascular cell adhesion protein 1. (736 aa)
Tgfb1Transforming growth factor beta-1. (286 aa)
Plce1Phosphoinositide phospholipase C. (2300 aa)
Serpine1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
ENSMAUP00000002714annotation not available (58 aa)
DhdhTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (297 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Col4a6Collagen alpha-6(IV) chain. (1691 aa)
Fn1Fibronectin isoform X7. (2476 aa)
LOC101835654Signal transducer and activator of transcription. (228 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1293 aa)
Nox4NADPH oxidase 4 isoform X4. (271 aa)
Plcd3Phosphoinositide phospholipase C. (785 aa)
Plcd4Phosphoinositide phospholipase C. (784 aa)
AgerAdvanced glycosylation end product-specific receptor. (405 aa)
LOC101836687Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
PrkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (623 aa)
Foxo1Forkhead box protein O1. (633 aa)
SeleLOW QUALITY PROTEIN: E-selectin. (555 aa)
Ccl2C-C motif chemokine. (143 aa)
Col4a3Collagen alpha-3(IV) chain. (1621 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Col4a1Collagen type IV alpha 1 chain. (1538 aa)
PrkcdProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
VegfcVascular endothelial growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (415 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (26%) [HD]