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Ticam1 Ticam1 Il1a Il1a Calm2 Calm2 Fos Fos Cxcl5 Cxcl5 Nlrp3 Nlrp3 Ccdc125 Ccdc125 Itgb2 Itgb2 Efcab3 Efcab3 Mapk12 Mapk12 Ticam2 Ticam2 Mapk11 Mapk11 Calm1 Calm1 Irf3 Irf3 Nod1 Nod1 Cfl2 Cfl2 Tmed7 Tmed7 Gnai1 Gnai1 Itgb1 Itgb1 C1r C1r Irak1 Irak1 Calml3 Calml3 Casp3 Casp3 Traf6 Traf6 Pycard Pycard Mapk8 Mapk8 Il12a Il12a Jun Jun C1rl C1rl ENSMAUP00000006097 ENSMAUP00000006097 Gnai3 Gnai3 Il10 Il10 Irf1 Irf1 Myd88 Myd88 Casp1 Casp1 Casp7 Casp7 C1qc C1qc Il12b Il12b Il23a Il23a Rhoc Rhoc Calm3 Calm3 Tmed3 Tmed3 Mapk3 Mapk3 Sftpa1 Sftpa1 Gnai2 Gnai2 C1qa C1qa Serping1 Serping1 C3 C3 Tnf Tnf Itgam Itgam Irf8 Irf8 Calml4 Calml4 Rhoa Rhoa C4b C4b Rela Rela Irak4 Irak4 Mapk14 Mapk14 Tirap Tirap Zp3r Zp3r 4930544G11Rik 4930544G11Rik Nos2 Nos2 C1qb C1qb C4bp C4bp Mapk10 Mapk10 Tlr4 Tlr4 Mapk1 Mapk1 Mapk13 Mapk13 Cd14 Cd14 Mapk9 Mapk9 Itga5 Itga5 Ly96 Ly96 Il1b Il1b Il6 Il6 C1s C1s Nfkb1 Nfkb1 Cfl1 Cfl1 LOC106021121 LOC106021121
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ticam1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (733 aa)
Il1aInterleukin-1; Belongs to the IL-1 family. (269 aa)
Calm2Calmodulin 2. (149 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
Cxcl5C-X-C motif chemokine. (129 aa)
Nlrp3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1036 aa)
Ccdc125Coiled-coil domain-containing protein 125. (309 aa)
Itgb2Integrin beta. (304 aa)
Efcab3EF-hand calcium-binding domain-containing protein 3. (430 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
Ticam2TIR domain-containing adapter molecule 2. (233 aa)
Mapk11Mitogen-activated protein kinase. (355 aa)
Calm1Calmodulin 1. (149 aa)
Irf3Interferon regulatory factor 3 isoform X1. (420 aa)
Nod1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
Cfl2Cofilin 2. (105 aa)
Tmed7Transmembrane emp24 domain-containing protein 7. (225 aa)
Gnai1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
Itgb1Integrin beta; Belongs to the integrin beta chain family. (92 aa)
C1rComplement C1r subcomponent; Belongs to the peptidase S1 family. (705 aa)
Irak1Interleukin-1 receptor-associated kinase 1 isoform X2. (747 aa)
Calml3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
Casp3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (246 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
PycardApoptosis-associated speck-like protein containing a CARD. (192 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (206 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
C1rlLOW QUALITY PROTEIN: complement C1r subcomponent-like protein; Belongs to the peptidase S1 family. (485 aa)
ENSMAUP00000006097annotation not available (76 aa)
Gnai3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
Il10Interleukin-10 isoform X1. (178 aa)
Irf1Interferon regulatory factor. (132 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Casp1Caspase-1-like; Belongs to the peptidase C14A family. (313 aa)
Casp7Caspase-7 subunit p11; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP- ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death (By similarity). (297 aa)
C1qcComplement C1q subcomponent subunit C. (245 aa)
Il12bInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (327 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
RhocRho-related GTP-binding protein RhoC. (193 aa)
Calm3Calmodulin-2 isoform X1; Belongs to the calmodulin family. (149 aa)
Tmed3Transmembrane emp24 domain-containing protein 3. (220 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Sftpa1Pulmonary surfactant-associated protein A. (248 aa)
Gnai2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
C1qaComplement C1q subcomponent subunit A. (245 aa)
Serping1Plasma protease C1 inhibitor; Belongs to the serpin family. (547 aa)
C3Complement C3. (1483 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ItgamIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1152 aa)
Irf8Interferon regulatory factor 8. (424 aa)
Calml4Calmodulin-like protein 4 isoform X2. (141 aa)
RhoaTransforming protein RhoA-like isoform X2. (141 aa)
C4bComplement C4 isoform X2. (1738 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
Irak4Interleukin-1 receptor-associated kinase 4. (461 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
TirapToll/interleukin-1 receptor domain-containing adapter protein isoform X2. (245 aa)
Zp3rZona pellucida sperm-binding protein 3 receptor-like. (580 aa)
4930544G11RikTransforming protein RhoA-like isoform X1. (193 aa)
Nos2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
C1qbComplement C1q subcomponent subunit B isoform X2. (254 aa)
C4bpC4b-binding protein alpha chain. (449 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Cd14Monocyte differentiation antigen CD14. (370 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
Itga5Integrin alpha-5; Belongs to the integrin alpha chain family. (1058 aa)
Ly96Lymphocyte antigen 96. (74 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Il6Interleukin-6. (212 aa)
C1sCalcium-dependent serine proteinase heavy chain; Capable of degrading extracellular matrix proteins. CASP degrades type I and IV collagen and fibronectin in the presence of calcium; Belongs to the peptidase S1 family. (695 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Cfl1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
LOC106021121Uncharacterized protein LOC106021121. (209 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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