STRINGSTRING
ENSMAUP00000004122 ENSMAUP00000004122 Casp3 Casp3 Trank1 Trank1 Gna11 Gna11 Ptk2 Ptk2 Tgfb1 Tgfb1 LOC101825458 LOC101825458 Prkacb Prkacb LOC101831400 LOC101831400 Arg1 Arg1 ENSMAUP00000002714 ENSMAUP00000002714 Col4a6 Col4a6 Fn1 Fn1 Pik3cd Pik3cd LOC110340206 LOC110340206 Itgam Itgam Lama3 Lama3 Rab7 Rab7 Lama1 Lama1 Il1r1 Il1r1 Rab17 Rab17 Serpinb8 Serpinb8 Rab7b Rab7b Tlr2 Tlr2 LOC101842215 LOC101842215 Actn4 Actn4 C8b C8b Prkcg Prkcg Tnf Tnf Lamc1 Lamc1 Serpinb13 Serpinb13 LOC101834284 LOC101834284 Smtn Smtn Ifng Ifng Specc1l Specc1l Prkcb Prkcb Lamb1 Lamb1 Plcb4 Plcb4 ENSMAUP00000012061 ENSMAUP00000012061 Lamb2 Lamb2 Itgb2 Itgb2 LOC110341725 LOC110341725 Col4a1 Col4a1 Pik3r2-2 Pik3r2-2 Lamc2 Lamc2 ENSMAUP00000024144 ENSMAUP00000024144 Col4a3 Col4a3 Col4a2 Col4a2 Pik3ca Pik3ca Col4a4 Col4a4 Hspb1 Hspb1 ENSMAUP00000021721 ENSMAUP00000021721 Col1a1 Col1a1 Arg2 Arg2 Il1r2 Il1r2 Ctsg Ctsg ENSMAUP00000021258 ENSMAUP00000021258 ENSMAUP00000021163 ENSMAUP00000021163 Gnas Gnas Col1a2 Col1a2 C9 C9 Nfkb1 Nfkb1 ENSMAUP00000019393 ENSMAUP00000019393 C8g C8g Il6 Il6 Il1b Il1b Cd14 Cd14 Tlr4 Tlr4 Pik3r2 Pik3r2 LOC101834882 LOC101834882 Gna15 Gna15 Smtnl1 Smtnl1 LOC101827575 LOC101827575 Nos2 Nos2 Dclk2 Dclk2 Rela Rela Plcb1 Plcb1 Lama5 Lama5 Cd1d Cd1d Rab5c Rab5c Prkaca Prkaca Serpinb10 Serpinb10 Vcl Vcl Prdx2 Prdx2 Tgfb3 Tgfb3 Plcb2 Plcb2 Il12a Il12a Pik3cb Pik3cb Ighm Ighm LOC106020742 LOC106020742 Pik3r1 Pik3r1 Prkca Prkca Lama4 Lama4 Serpinb6b Serpinb6b Il10 Il10 Csf2 Csf2 LOC101832132 LOC101832132 LOC101835557 LOC101835557 Specc1 Specc1 Tgfb2 Tgfb2 Lama2 Lama2 Gna14 Gna14 Gnaq Gnaq Col3a1 Col3a1 Il12b Il12b Rab5a Rab5a Col4a5 Col4a5 Prdx1 Prdx1 Lamb3 Lamb3 Rab5b Rab5b Gnal Gnal ENSMAUP00000010921 ENSMAUP00000010921 Adcy1 Adcy1 C8a C8a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMAUP00000004122annotation not available (116 aa)
Casp3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (246 aa)
Trank1TPR and ankyrin repeat-containing protein 1. (2952 aa)
Gna11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (667 aa)
Tgfb1Transforming growth factor beta-1. (286 aa)
LOC101825458Alpha-actinin-4. (692 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
Arg1Arginase. (323 aa)
ENSMAUP00000002714annotation not available (58 aa)
Col4a6Collagen alpha-6(IV) chain. (1691 aa)
Fn1Fibronectin isoform X7. (2476 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC110340206Serpin B9-like; Belongs to the serpin family. (189 aa)
ItgamIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1152 aa)
Lama3Laminin subunit alpha-3. (3273 aa)
Rab7Ras-related protein Rab-7a. (177 aa)
Lama1Laminin subunit alpha-1-like. (2112 aa)
Il1r1Interleukin-1 receptor type 1. (293 aa)
Rab17Ras-related protein Rab-17. (212 aa)
Serpinb8Serpin B8; Belongs to the serpin family. (374 aa)
Rab7bRas-related protein Rab-7b. (157 aa)
Tlr2Toll-like receptor. (784 aa)
LOC101842215Serpin B6. (284 aa)
Actn4Actinin alpha 4. (523 aa)
C8bComplement component C8 beta chain isoform X1. (588 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (612 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Lamc1Laminin subunit gamma-1. (1607 aa)
Serpinb13Serpin B13 isoform X2; Belongs to the serpin family. (389 aa)
LOC101834284Neuroendocrine secretory protein 55-like. (250 aa)
SmtnSmoothelin. (860 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (174 aa)
Specc1lcytospin-A isoform X2. (1135 aa)
PrkcbProtein kinase C beta. (554 aa)
Lamb1Laminin subunit beta-1. (1834 aa)
Plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa)
ENSMAUP00000012061annotation not available (121 aa)
Lamb2Laminin subunit beta-2 isoform X1. (1800 aa)
Itgb2Integrin beta. (304 aa)
LOC110341725Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (854 aa)
Col4a1Collagen type IV alpha 1 chain. (1538 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Lamc2Laminin subunit gamma-2. (1168 aa)
ENSMAUP00000024144annotation not available (159 aa)
Col4a3Collagen alpha-3(IV) chain. (1621 aa)
Col4a2Collagen type IV alpha 2 chain. (1472 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Col4a4Collagen alpha-4(IV) chain. (157 aa)
Hspb1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (212 aa)
ENSMAUP00000021721annotation not available (153 aa)
Col1a1Collagen alpha-1(I) chain isoform X1. (1453 aa)
Arg2Arginase. (354 aa)
Il1r2Interleukin-1 receptor type 2. (351 aa)
CtsgCathepsin G-like; Belongs to the peptidase S1 family. (264 aa)
ENSMAUP00000021258annotation not available (228 aa)
ENSMAUP00000021163annotation not available (137 aa)
GnasGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (394 aa)
Col1a2Collagen alpha-2(I) chain. (1372 aa)
C9Complement component C9. (570 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
ENSMAUP00000019393annotation not available (70 aa)
C8gComplement component C8 gamma chain isoform X1. (202 aa)
Il6Interleukin-6. (212 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Cd14Monocyte differentiation antigen CD14. (370 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
LOC101834882C-X-C motif chemokine. (96 aa)
Gna15Guanine nucleotide-binding protein subunit alpha-15 isoform X1. (374 aa)
Smtnl1Smoothelin-like protein 1 isoform X1. (190 aa)
LOC101827575C-X-C motif chemokine. (68 aa)
Nos2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
Dclk2Serine/threonine-protein kinase DCLK2-like isoform X2. (625 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
Lama5Laminin subunit alpha-5. (3717 aa)
Cd1dAntigen-presenting glycoprotein CD1d isoform X2. (329 aa)
Rab5cRas-related protein Rab-5C. (216 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Serpinb10Serpin B10; Belongs to the serpin family. (397 aa)
VclVinculin isoform X1. (1129 aa)
Prdx2Peroxiredoxin-2. (198 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (206 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
IghmIg mu chain C region. (454 aa)
LOC106020742Serpin B9; Belongs to the serpin family. (324 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
Lama4Laminin subunit alpha-4. (1610 aa)
Serpinb6bSerpin B6-like; Belongs to the serpin family. (375 aa)
Il10Interleukin-10 isoform X1. (178 aa)
Csf2Granulocyte-macrophage colony-stimulating factor. (142 aa)
LOC101832132Serpin B4 isoform X1; Belongs to the serpin family. (389 aa)
LOC101835557Serpin B9; Belongs to the serpin family. (360 aa)
Specc1cytospin-B. (1039 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Lama2Laminin subunit alpha-2 isoform X3. (3109 aa)
Gna14Guanine nucleotide-binding protein subunit alpha-14 isoform X1. (355 aa)
GnaqGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
Col3a1Collagen alpha-1(III) chain. (1465 aa)
Il12bInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (327 aa)
Rab5aRas-related protein Rab-5A. (215 aa)
Col4a5Collagen alpha-5(IV) chain isoform X2. (438 aa)
Prdx1Peroxiredoxin-1. (197 aa)
Lamb3Laminin subunit beta-3 isoform X1. (1171 aa)
Rab5bRas-related protein Rab-5B. (215 aa)
GnalGuanine nucleotide-binding protein G(Olf) subunit alpha. (142 aa)
ENSMAUP00000010921annotation not available (677 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1118 aa)
C8aComplement component C8 alpha chain. (582 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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