STRINGSTRING
Stat1 Stat1 Fcgr2b Fcgr2b Vdr Vdr Rela Rela Raf1 Raf1 Irak4 Irak4 Cd74 Cd74 Cd209b Cd209b Mapk14 Mapk14 Tirap Tirap Akt3 Akt3 4930544G11Rik 4930544G11Rik Cd209a Cd209a Nos2 Nos2 Coro1b Coro1b Lamp2 Lamp2 Bpi Bpi Cyct Cyct Mapk10 Mapk10 Tlr4 Tlr4 Mapk1 Mapk1 Cr1l Cr1l Mapk13 Mapk13 Cd14 Cd14 Mapk9 Mapk9 Tlr9 Tlr9 Il1b Il1b Il6 Il6 LOC106021236 LOC106021236 Fadd Fadd Hspd1 Hspd1 Coro1c Coro1c Nfkb1 Nfkb1 LOC101843733 LOC101843733 Rfx5 Rfx5 Plk3 Plk3 Creb1 Creb1 Lsp1 Lsp1 Casp8 Casp8 Il1a Il1a Clec4e Clec4e Ifitm10 Ifitm10 Nfyc Nfyc Fcgr4 Fcgr4 ENSMAUP00000021258 ENSMAUP00000021258 ENSMAUP00000021279 ENSMAUP00000021279 Syk Syk Il10ra Il10ra Calm2 Calm2 Camk2b Camk2b Camk2a Camk2a Nfya Nfya Ctsd Ctsd H2-Ab1 H2-Ab1 Card9 Card9 Nfyb Nfyb Akt2 Akt2 ENSMAUP00000024144 ENSMAUP00000024144 Atp6v0d1 Atp6v0d1 Ctss Ctss Itgb2 Itgb2 Mrc2 Mrc2 Efcab3 Efcab3 Mapk12 Mapk12 LOC106021121 LOC106021121 Atp6v0a4 Atp6v0a4 Calm1 Calm1 Mapk11 Mapk11 Tlr1 Tlr1 Arsi Arsi Tradd Tradd Atp6v1h Atp6v1h Rab17 Rab17 Ppp3cc Ppp3cc LOC101842058 LOC101842058 H2-DMa H2-DMa Tlr2 Tlr2 ENSMAUP00000001870 ENSMAUP00000001870 Atp6v0d2 Atp6v0d2 Clec4g Clec4g Pla2r1 Pla2r1 Dhdh Dhdh Ppp3r2 Ppp3r2 Rfxank Rfxank Irak1 Irak1 Atp6v0a1 Atp6v0a1 Tnfrsf1a Tnfrsf1a Rfxap Rfxap H2-Aa H2-Aa Tgfb1 Tgfb1 Malt1 Malt1 Nod2 Nod2 Ep300 Ep300 Ppp3cb Ppp3cb Calml3 Calml3 LOC101824534 LOC101824534 Casp3 Casp3 Ifngr1 Ifngr1 ENSMAUP00000004122 ENSMAUP00000004122 Camk2g Camk2g Traf6 Traf6 Tgfb3 Tgfb3 Mapk8 Mapk8 Il12a Il12a Lbp Lbp LOC106021303 LOC106021303 CUNH7orf31 CUNH7orf31 Ksr1 Ksr1 Cebpg Cebpg H2-Ob H2-Ob Ighm Ighm Apaf1 Apaf1 Tlr6 Tlr6 Cyp27b1 Cyp27b1 ENSMAUP00000006097 ENSMAUP00000006097 Sphk2 Sphk2 Jak2 Jak2 Itgax Itgax Eea1 Eea1 Plk5 Plk5 ENSMAUP00000007177 ENSMAUP00000007177 Ripk2 Ripk2 Pik3c3 Pik3c3 Il10 Il10 ENSMAUP00000007509 ENSMAUP00000007509 Hspa9 Hspa9 Mrc1 Mrc1 Clec7a Clec7a Src Src Jak1 Jak1 LOC110340161 LOC110340161 Tgfb2 Tgfb2 Sphk1 Sphk1 Myd88 Myd88 Crebbp Crebbp Bcl2 Bcl2 Il12b Il12b Rab5a Rab5a Il23a Il23a Bcl10 Bcl10 Rhoc Rhoc Calm3 Calm3 Rab5b Rab5b ENSMAUP00000010883 ENSMAUP00000010883 Ciita Ciita Cd209e Cd209e Ankra2 Ankra2 Coro6 Coro6 Mapk3 Mapk3 Ppp3ca Ppp3ca LOC101827037 LOC101827037 ENSMAUP00000012115 ENSMAUP00000012115 Akt1 Akt1 Coro1a Coro1a Arhgef12 Arhgef12 ENSMAUP00000013263 ENSMAUP00000013263 Il18 Il18 Bad Bad C3 C3 Ifng Ifng Camk2d Camk2d H2-Oa H2-Oa ENSMAUP00000014320 ENSMAUP00000014320 Tcirg1 Tcirg1 Tnf Tnf Casp9 Casp9 H2-Ea-ps H2-Ea-ps Atp6ap1 Atp6ap1 Rab7 Rab7 Ppp3r1 Ppp3r1 ENSMAUP00000015128 ENSMAUP00000015128 Camp Camp Itgam Itgam Rab5c Rab5c Calml4 Calml4 Rhoa Rhoa Fcer1g Fcer1g Bax Bax
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Stat1Signal transducer and activator of transcription. (749 aa)
Fcgr2bLow affinity immunoglobulin gamma Fc region receptor II-b isoform X2. (340 aa)
VdrVitamin D3 receptor. (423 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
Irak4Interleukin-1 receptor-associated kinase 4. (461 aa)
Cd74HLA class II histocompatibility antigen gamma chain isoform X1. (289 aa)
Cd209bCD209 antigen-like protein B isoform X2. (326 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
TirapToll/interleukin-1 receptor domain-containing adapter protein isoform X2. (245 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
4930544G11RikTransforming protein RhoA-like isoform X1. (193 aa)
Cd209aCD209 antigen-like protein A. (211 aa)
Nos2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
Coro1bCoronin; Belongs to the WD repeat coronin family. (484 aa)
Lamp2Lysosome-associated membrane glycoprotein 2 isoform X3. (425 aa)
BpiBactericidal permeability-increasing protein. (481 aa)
CyctCytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Cr1lComplement component receptor 1-like protein. (401 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Cd14Monocyte differentiation antigen CD14. (370 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
Tlr9Toll-like receptor 9. (1030 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Il6Interleukin-6. (212 aa)
LOC106021236LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like; Belongs to the chaperonin (HSP60) family. (569 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
Hspd160 kDa heat shock protein, mitochondrial. (387 aa)
Coro1cCoronin; Belongs to the WD repeat coronin family. (66 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
LOC101843733H-2 class II histocompatibility antigen, E-D beta chain-like. (181 aa)
Rfx5DNA-binding protein RFX5. (131 aa)
Plk3Serine/threonine-protein kinase PLK. (648 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Lsp1Lymphocyte-specific protein 1 isoform X1. (330 aa)
Casp8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (481 aa)
Il1aInterleukin-1; Belongs to the IL-1 family. (269 aa)
Clec4eC-type lectin domain family 4 member E. (215 aa)
Ifitm10Interferon-induced transmembrane protein 10. (199 aa)
NfycNuclear transcription factor Y subunit gamma. (335 aa)
Fcgr4Low affinity immunoglobulin gamma Fc region receptor III-like precursor. (251 aa)
ENSMAUP00000021258annotation not available (228 aa)
ENSMAUP00000021279annotation not available (98 aa)
SykTyrosine-protein kinase. (629 aa)
Il10raInterleukin-10 receptor subunit alpha isoform X2. (573 aa)
Calm2Calmodulin 2. (149 aa)
Camk2bCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X4. (666 aa)
Camk2aCalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (459 aa)
NfyaNuclear transcription factor Y subunit alpha isoform X1. (347 aa)
CtsdCathepsin D; Belongs to the peptidase A1 family. (410 aa)
H2-Ab1Rano class II histocompatibility antigen, A beta chain-like. (263 aa)
Card9Caspase recruitment domain-containing protein 9 isoform X2. (537 aa)
NfybNuclear transcription factor Y subunit beta isoform X1. (207 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSMAUP00000024144annotation not available (159 aa)
Atp6v0d1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
CtssCathepsin S; Belongs to the peptidase C1 family. (301 aa)
Itgb2Integrin beta. (304 aa)
Mrc2C-type mannose receptor 2 isoform X1. (1483 aa)
Efcab3EF-hand calcium-binding domain-containing protein 3. (430 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
LOC106021121Uncharacterized protein LOC106021121. (209 aa)
Atp6v0a4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
Calm1Calmodulin 1. (149 aa)
Mapk11Mitogen-activated protein kinase. (355 aa)
Tlr1Toll-like receptor 1; Belongs to the Toll-like receptor family. (794 aa)
ArsiArylsulfatase I. (573 aa)
TraddTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (310 aa)
Atp6v1hV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
Rab17Ras-related protein Rab-17. (212 aa)
Ppp3ccSerine/threonine-protein phosphatase. (514 aa)
LOC101842058Cytochrome c, somatic-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
H2-DMaClass II histocompatibility antigen, M alpha chain; Belongs to the MHC class II family. (261 aa)
Tlr2Toll-like receptor. (784 aa)
ENSMAUP00000001870annotation not available (99 aa)
Atp6v0d2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
Clec4gC-type lectin domain family 4 member G. (293 aa)
Pla2r1Secretory phospholipase A2 receptor isoform X1. (1484 aa)
DhdhTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (297 aa)
Ppp3r2Calcineurin subunit B type 2. (183 aa)
RfxankDNA-binding protein RFXANK isoform X6. (259 aa)
Irak1Interleukin-1 receptor-associated kinase 1 isoform X2. (747 aa)
Atp6v0a1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (800 aa)
Tnfrsf1aTumor necrosis factor receptor superfamily member 1A. (468 aa)
RfxapRegulatory factor X-associated protein. (238 aa)
H2-AaH-2 class II histocompatibility antigen, A-U alpha chain. (173 aa)
Tgfb1Transforming growth factor beta-1. (286 aa)
Malt1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X2. (823 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2 isoform X2. (1023 aa)
Ep300Histone acetyltransferase p300 isoform X3. (2417 aa)
Ppp3cbSerine/threonine-protein phosphatase. (483 aa)
Calml3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
LOC101824534Interferon alpha-12-like. (183 aa)
Casp3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (246 aa)
Ifngr1Interferon gamma receptor 1. (478 aa)
ENSMAUP00000004122annotation not available (116 aa)
Camk2gCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3. (559 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (206 aa)
LbpLipopolysaccharide-binding protein. (481 aa)
LOC106021303Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
CUNH7orf31Uncharacterized protein C7orf31 homolog isoform X1. (589 aa)
Ksr1Kinase suppressor of Ras 1 isoform X4. (912 aa)
CebpgCCAAT/enhancer-binding protein gamma. (150 aa)
H2-ObHLA class II histocompatibility antigen, DO beta chain. (274 aa)
IghmIg mu chain C region. (454 aa)
Apaf1Apoptotic protease-activating factor 1. (222 aa)
Tlr6Toll-like receptor 6; Belongs to the Toll-like receptor family. (789 aa)
Cyp27b125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
ENSMAUP00000006097annotation not available (76 aa)
Sphk2Sphingosine kinase 2 isoform X2. (613 aa)
Jak2Tyrosine-protein kinase. (1132 aa)
ItgaxIntegrin alpha-X; Belongs to the integrin alpha chain family. (879 aa)
Eea1Early endosome antigen 1. (1411 aa)
Plk5Inactive serine/threonine-protein kinase PLK5. (579 aa)
ENSMAUP00000007177annotation not available (91 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (325 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (898 aa)
Il10Interleukin-10 isoform X1. (178 aa)
ENSMAUP00000007509annotation not available (458 aa)
Hspa9Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (656 aa)
Mrc1Macrophage mannose receptor 1. (1401 aa)
Clec7aC-type lectin domain family 7 member A isoform X2. (243 aa)
SrcTyrosine-protein kinase. (536 aa)
Jak1Tyrosine-protein kinase. (1161 aa)
LOC110340161C-type lectin domain family 4 member A-like. (151 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Sphk1Sphingosine kinase 1 isoform X2. (382 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
CrebbpCREB-binding protein. (2433 aa)
Bcl2Apoptosis regulator Bcl-2. (236 aa)
Il12bInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (327 aa)
Rab5aRas-related protein Rab-5A. (215 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
Bcl10B-cell lymphoma/leukemia 10. (232 aa)
RhocRho-related GTP-binding protein RhoC. (193 aa)
Calm3Calmodulin-2 isoform X1; Belongs to the calmodulin family. (149 aa)
Rab5bRas-related protein Rab-5B. (215 aa)
ENSMAUP00000010883annotation not available (214 aa)
CiitaMHC class II transactivator isoform X2. (1157 aa)
Cd209eCD209 antigen-like protein E. (214 aa)
Ankra2Ankyrin repeat family A protein 2 isoform X1. (313 aa)
Coro6Coronin; Belongs to the WD repeat coronin family. (472 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Ppp3caSerine/threonine-protein phosphatase. (521 aa)
LOC101827037V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (179 aa)
ENSMAUP00000012115annotation not available (87 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Coro1aCoronin; Belongs to the WD repeat coronin family. (461 aa)
Arhgef12Rho guanine nucleotide exchange factor 12 isoform X1. (1544 aa)
ENSMAUP00000013263annotation not available (231 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (197 aa)
BadBcl2-associated agonist of cell death isoform X1. (204 aa)
C3Complement C3. (1483 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (174 aa)
Camk2dCalcium/calmodulin-dependent protein kinase type II subunit delta. (160 aa)
H2-OaHLA class II histocompatibility antigen, DO alpha chain isoform X1; Belongs to the MHC class II family. (250 aa)
ENSMAUP00000014320annotation not available (157 aa)
Tcirg1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Casp9Caspase-9; Belongs to the peptidase C14A family. (440 aa)
H2-Ea-psH-2 class II histocompatibility antigen, E-U alpha chain; Belongs to the MHC class II family. (256 aa)
Atp6ap1V-type proton ATPase subunit S1. (463 aa)
Rab7Ras-related protein Rab-7a. (177 aa)
Ppp3r1Protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I). (157 aa)
ENSMAUP00000015128annotation not available (114 aa)
CampCathelicidin antimicrobial peptide. (175 aa)
ItgamIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1152 aa)
Rab5cRas-related protein Rab-5C. (216 aa)
Calml4Calmodulin-like protein 4 isoform X2. (141 aa)
RhoaTransforming protein RhoA-like isoform X2. (141 aa)
Fcer1gHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
BaxApoptosis regulator BAX isoform X1. (192 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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