STRINGSTRING
Rack1 Rack1 Ccne2 Ccne2 Cd209e Cd209e LOC110339561 LOC110339561 ENSMAUP00000012115 ENSMAUP00000012115 Hspa8 Hspa8 Stat2 Stat2 Akt1 Akt1 Bad Bad Ifnar1 Ifnar1 Oas3 Oas3 Casp9 Casp9 Mavs Mavs ENSMAUP00000015128 ENSMAUP00000015128 Eif2s1 Eif2s1 Nfkbib Nfkbib Ikbkb Ikbkb Oas1 Oas1 ENSMAUP00000015826 ENSMAUP00000015826 Stat1 Stat1 Bax Bax Fcgr2b Fcgr2b Hspa1l Hspa1l Rela Rela Gsk3b Gsk3b Adar Adar Irak4 Irak4 Cd209b Cd209b Cd46 Cd46 ENSMAUP00000017208 ENSMAUP00000017208 Akt3 Akt3 Cd209a Cd209a Cyct Cyct Ccnd2 Ccnd2 Irf9 Irf9 Map3k7 Map3k7 Mx2 Mx2 Pik3r2 Pik3r2 Mapk10 Mapk10 Tlr4 Tlr4 Il2 Il2 Mapk9 Mapk9 Chuk Chuk Tlr9 Tlr9 Il1b Il1b Il6 Il6 Ccnd1 Ccnd1 Fadd Fadd Tlr7 Tlr7 Tyk2 Tyk2 Nfkb1 Nfkb1 Il2rb Il2rb Bak1 Bak1 Eif3h Eif3h Cdkn1b Cdkn1b Casp8 Casp8 ENSMAUP00000020463 ENSMAUP00000020463 Il1a Il1a ENSMAUP00000020843 ENSMAUP00000020843 ENSMAUP00000021279 ENSMAUP00000021279 Cdk2 Cdk2 Fos Fos Tnfaip3 Tnfaip3 Rchy1 Rchy1 Pik3ca Pik3ca Irf7 Irf7 Cd28 Cd28 Akt2 Akt2 Cdk6 Cdk6 Pik3r2-2 Pik3r2-2 Csnk2b Csnk2b Traf3 Traf3 LOC101823672 LOC101823672 ENSMAUP00000025153 ENSMAUP00000025153 Ddx58 Ddx58 ENSMAUP00000025330 ENSMAUP00000025330 Csnk2a1 Csnk2a1 Irf3 Irf3 Tp53 Tp53 Il2ra Il2ra Eif2ak1 Eif2ak1 Hspa2 Hspa2 Ccne1 Ccne1 ENSMAUP00000003031 ENSMAUP00000003031 Irak1 Irak1 LOC101831400 LOC101831400 Dhdh Dhdh LOC106021986 LOC106021986 Clec4g Clec4g LOC101835654 LOC101835654 Pik3cd Pik3cd ENSMAUP00000001870 ENSMAUP00000001870 Slamf1 Slamf1 Tlr2 Tlr2 LOC101842058 LOC101842058 Eif2ak3 Eif2ak3 Tbk1 Tbk1 ENSMAUP00000000683 ENSMAUP00000000683 Tradd Tradd Eif2ak2 Eif2ak2 Mx1 Mx1 Bcl2l1 Bcl2l1 LOC101824534 LOC101824534 Casp3 Casp3 Eif2ak4 Eif2ak4 Traf6 Traf6 Nfkbia Nfkbia LOC101842510 LOC101842510 Mapk8 Mapk8 Il12a Il12a Msn Msn Pik3cb Pik3cb Jun Jun LOC106021303 LOC106021303 CUNH7orf31 CUNH7orf31 LOC106021992 LOC106021992 Apaf1 Apaf1 Cd3d Cd3d Faslg Faslg Csnk2a2 Csnk2a2 Pik3r1 Pik3r1 Ikbke Ikbke Cd3g Cd3g Ikbkg Ikbkg Stat3 Stat3 Fas Fas Bbc3 Bbc3 Cd3e Cd3e Oas2 Oas2 Jak1 Jak1 Myd88 Myd88 Rab9b Rab9b Ccnd3 Ccnd3 Jak3 Jak3 Tp73 Tp73 Cdk4 Cdk4 Bcl2 Bcl2 Tab2 Tab2 Il2rg Il2rg
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rack1Receptor of activated protein C kinase 1. (147 aa)
Ccne2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
Cd209eCD209 antigen-like protein E. (214 aa)
LOC110339561Signal transducer and activator of transcription 5B-like. (125 aa)
ENSMAUP00000012115annotation not available (87 aa)
Hspa8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (646 aa)
Stat2Signal transducer and activator of transcription 2. (634 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BadBcl2-associated agonist of cell death isoform X1. (204 aa)
Ifnar1Interferon alpha/beta receptor 1. (543 aa)
Oas32'-5'-oligoadenylate synthase 3 isoform X2. (131 aa)
Casp9Caspase-9; Belongs to the peptidase C14A family. (440 aa)
MavsMitochondrial antiviral-signaling protein isoform X1. (498 aa)
ENSMAUP00000015128annotation not available (114 aa)
Eif2s1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
NfkbibNF-kappa-B inhibitor beta. (358 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (757 aa)
Oas12'-5'-oligoadenylate synthase 1 isoform X2. (39 aa)
ENSMAUP00000015826annotation not available (113 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
BaxApoptosis regulator BAX isoform X1. (192 aa)
Fcgr2bLow affinity immunoglobulin gamma Fc region receptor II-b isoform X2. (340 aa)
Hspa1lHeat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (629 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
Gsk3bGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (429 aa)
AdarDouble-stranded RNA-specific adenosine deaminase isoform X3. (925 aa)
Irak4Interleukin-1 receptor-associated kinase 4. (461 aa)
Cd209bCD209 antigen-like protein B isoform X2. (326 aa)
Cd46Membrane cofactor protein. (364 aa)
ENSMAUP00000017208annotation not available (174 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Cd209aCD209 antigen-like protein A. (211 aa)
CyctCytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
Irf9Interferon regulatory factor 9 isoform X1. (390 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (497 aa)
Mx2Myxovirus (Influenza virus) resistance 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (584 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Il2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Tlr9Toll-like receptor 9. (1030 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Il6Interleukin-6. (212 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
Tlr7Toll-like receptor 7 isoform X1; Belongs to the Toll-like receptor family. (1050 aa)
Tyk2Tyrosine-protein kinase. (1190 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Il2rbInterleukin-2 receptor subunit beta. (415 aa)
Bak1Bcl-2 homologous antagonist/killer. (209 aa)
Eif3hEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (256 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (198 aa)
Casp8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (481 aa)
ENSMAUP00000020463annotation not available (168 aa)
Il1aInterleukin-1; Belongs to the IL-1 family. (269 aa)
ENSMAUP00000020843annotation not available (239 aa)
ENSMAUP00000021279annotation not available (98 aa)
Cdk2Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (346 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
Tnfaip3Tumor necrosis factor alpha-induced protein 3 isoform X1. (776 aa)
Rchy1RING finger and CHY zinc finger domain-containing protein 1. (259 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Irf7Interferon regulatory factor 7 isoform X1. (394 aa)
Cd28T-cell-specific surface glycoprotein CD28. (219 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Cdk6Cyclin-dependent kinase 6. (203 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Csnk2bCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
Traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
LOC1018236722'-5'-oligoadenylate synthase 1A-like. (157 aa)
ENSMAUP00000025153annotation not available (525 aa)
Ddx58Putative ATP-dependent RNA helicase DDX58. (908 aa)
ENSMAUP00000025330annotation not available (154 aa)
Csnk2a1LOW QUALITY PROTEIN: casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (380 aa)
Irf3Interferon regulatory factor 3 isoform X1. (420 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
Il2raInterleukin-2 receptor subunit alpha. (267 aa)
Eif2ak1Eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1. (622 aa)
Hspa2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (633 aa)
Ccne1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
ENSMAUP00000003031annotation not available (117 aa)
Irak1Interleukin-1 receptor-associated kinase 1 isoform X2. (747 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
DhdhTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (297 aa)
LOC1060219862'-5'-oligoadenylate synthase 1A-like. (280 aa)
Clec4gC-type lectin domain family 4 member G. (293 aa)
LOC101835654Signal transducer and activator of transcription. (228 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ENSMAUP00000001870annotation not available (99 aa)
Slamf1Signaling lymphocytic activation molecule. (339 aa)
Tlr2Toll-like receptor. (784 aa)
LOC101842058Cytochrome c, somatic-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
Eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1095 aa)
Tbk1Serine/threonine-protein kinase TBK1. (729 aa)
ENSMAUP00000000683annotation not available (256 aa)
TraddTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (310 aa)
Eif2ak2Interferon-induced, double-stranded RNA-activated protein kinase isoform X1. (517 aa)
Mx1Interferon-induced GTP-binding protein Mx1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (577 aa)
Bcl2l1Bcl-2-like protein 1. (233 aa)
LOC101824534Interferon alpha-12-like. (183 aa)
Casp3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (246 aa)
Eif2ak4eIF-2-alpha kinase GCN2. (1510 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
NfkbiaNF-kappa-B inhibitor alpha. (314 aa)
LOC101842510Signal transducer and activator of transcription 5A. (228 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (206 aa)
MsnMoesin. (579 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
LOC106021303Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
CUNH7orf31Uncharacterized protein C7orf31 homolog isoform X1. (589 aa)
LOC1060219922'-5'-oligoadenylate synthase 1A-like. (296 aa)
Apaf1Apoptotic protease-activating factor 1. (222 aa)
Cd3dT-cell surface glycoprotein CD3 delta chain precursor. (171 aa)
FaslgTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (279 aa)
Csnk2a2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (325 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (715 aa)
Cd3gT-cell surface glycoprotein CD3 gamma chain. (182 aa)
IkbkgNF-kappa-B essential modulator isoform X1. (412 aa)
Stat3Signal transducer and activator of transcription. (758 aa)
FasTumor necrosis factor receptor superfamily member 6 isoform X1. (323 aa)
Bbc3Bcl-2-binding component 3 isoform X2. (193 aa)
Cd3eT-cell surface glycoprotein CD3 epsilon chain. (188 aa)
Oas22'-5'-oligoadenylate synthase 2 isoform X1. (725 aa)
Jak1Tyrosine-protein kinase. (1161 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Rab9bRas-related protein Rab-9B. (201 aa)
Ccnd3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
Jak3Tyrosine-protein kinase. (1080 aa)
Tp73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (286 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Bcl2Apoptosis regulator Bcl-2. (236 aa)
Tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
Il2rgCytokine receptor common subunit gamma isoform X1. (363 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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