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| | Plcg2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa) |
| | Ezr | Ezrin. (576 aa) |
| | Cav2 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa) |
| | Vegfa | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (248 aa) |
| | Ankrd60 | Ankyrin repeat domain-containing protein 60. (320 aa) |
| | Pik3cb | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | Esr1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | Smad2 | Mothers against decapentaplegic homolog. (467 aa) |
| | Msn | Moesin. (579 aa) |
| | Actl7b | Actin-like protein 7B; Belongs to the actin family. (417 aa) |
| | Cav1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa) |
| | Wnt2b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa) |
| | Mmp9 | Matrix metalloproteinase-9. (718 aa) |
| | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3. (559 aa) |
| | Actl7a | Actin-like protein 7A; Belongs to the actin family. (440 aa) |
| | Prkaca | cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa) |
| | Casp3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (246 aa) |
| | Cd44 | CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its c [...] (431 aa) |
| | Cdc42 | Cell division control protein 42 homolog isoform X1. (191 aa) |
| | Ptk2 | Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (667 aa) |
| | Actl9 | Actin-like protein 9; Belongs to the actin family. (415 aa) |
| | Eras | GTPase ERas. (228 aa) |
| | Tgfb1 | Transforming growth factor beta-1. (286 aa) |
| | Plau | Urokinase-type plasminogen activator. (433 aa) |
| | Plce1 | Phosphoinositide phospholipase C. (2300 aa) |
| | Twist2 | Twist-related protein 2. (160 aa) |
| | Nudt16l1 | Tudor-interacting repair regulator protein. (211 aa) |
| | Drosha | Ribonuclease 3 isoform X5. (1375 aa) |
| | Prkacb | cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa) |
| | LOC101831400 | Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa) |
| | ENSMAUP00000002714 | annotation not available (58 aa) |
| | Wnt10a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (418 aa) |
| | Fn1 | Fibronectin isoform X7. (2476 aa) |
| | Actg1 | Actin gamma 1. (133 aa) |
| | Wnt6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | Pik3cd | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | Vtn | Vitronectin. (486 aa) |
| | Plcg1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1293 aa) |
| | Prkcg | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (612 aa) |
| | ENSMAUP00000001689 | annotation not available (1186 aa) |
| | Hbegf | Proheparin-binding EGF-like growth factor. (202 aa) |
| | Slc9a1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (412 aa) |
| | Ctnnb1 | Catenin beta-1. (781 aa) |
| | Tlr2 | Toll-like receptor. (784 aa) |
| | Cdkn1a | Cyclin-dependent kinase inhibitor 1. (163 aa) |
| | Ppp1cc | Protein phosphatase 1 catalytic subunit gamma. (216 aa) |
| | Itgb1 | Integrin beta; Belongs to the integrin beta chain family. (92 aa) |
| | Gpc3 | Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa) |
| | Ank1 | Ankyrin-1 isoform X17. (1907 aa) |
| | Ctsv | Cathepsin L2 precursor; Belongs to the peptidase C1 family. (300 aa) |
| | Egfr | Receptor protein-tyrosine kinase. (1207 aa) |
| | Fzd1 | Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa) |
| | ENSMAUP00000000473 | annotation not available (187 aa) |
| | Timp3 | Metalloproteinase inhibitor 3. (211 aa) |
| | Fzd4 | Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (535 aa) |
| | Sos1 | Son of sevenless homolog 1. (1319 aa) |
| | Arsi | Arylsulfatase I. (573 aa) |
| | Fzd6 | Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (684 aa) |
| | Mapk11 | Mitogen-activated protein kinase. (355 aa) |
| | Tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa) |
| | Rras | Ras-related protein R-Ras. (218 aa) |
| | Cbl | E3 ubiquitin-protein ligase CBL. (51 aa) |
| | Mapk12 | Mitogen-activated protein kinase. (367 aa) |
| | Fzd5 | Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa) |
| | Dcn | Decorin; May affect the rate of fibrils formation. (362 aa) |
| | Fzd2 | Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (567 aa) |
| | Ppp1r12a | Protein phosphatase 1 regulatory subunit. (1036 aa) |
| | Wnt9a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (191 aa) |
| | Wnt5b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa) |
| | Wnt3a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | Ppp1r12c | Protein phosphatase 1 regulatory subunit. (757 aa) |
| | Erbb4 | Receptor protein-tyrosine kinase. (1308 aa) |
| | Erbb2 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1247 aa) |
| | Vav1 | Proto-oncogene vav. (845 aa) |
| | Pik3r2-2 | Phosphoinositide-3-kinase regulatory subunit 2. (71 aa) |
| | Thbs1 | Thrombospondin-1 isoform X1. (1171 aa) |
| | Akt2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | Igf1 | Insulin-like growth factor 1. (153 aa) |
| | Iqank1 | Putative IQ motif and ankyrin repeat domain-containing protein LOC642574 homolog. (572 aa) |
| | Fzd3 | Frizzled-3 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | Flnc | Filamin C. (1902 aa) |
| | Hpse2 | Inactive heparanase-2 isoform X1. (592 aa) |
| | ENSMAUP00000022949 | annotation not available (104 aa) |
| | Actl11 | Uncharacterized protein LOC101835075; Belongs to the actin family. (1219 aa) |
| | Itpr3 | Inositol 1,4,5-trisphosphate receptor type 3. (2660 aa) |
| | Hras | GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa) |
| | Hif1a | Hypoxia-inducible factor 1-alpha isoform X1. (246 aa) |
| | Nras | NRAS proto-oncogene, GTPase. (98 aa) |
| | Pik3ca | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (459 aa) |
| | Camk2b | Calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4. (666 aa) |
| | Sdc4 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa) |
| | Igf2 | Insulin-like growth factor II isoform X1. (191 aa) |
| | Tfap4 | Transcription factor AP-4. (316 aa) |
| | Cd63 | Tetraspanin. (238 aa) |
| | Col1a1 | Collagen alpha-1(I) chain isoform X1. (1453 aa) |
| | Cav3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa) |
| | Cttn | Src substrate cortactin isoform X1. (554 aa) |
| | LOC101827846 | Coiled-coil domain-containing protein 170-like. (352 aa) |
| | Cts8 | Cathepsin M-like; Belongs to the peptidase C1 family. (333 aa) |
| | Col1a2 | Collagen alpha-2(I) chain. (1372 aa) |
| | Rras2 | Ras-related protein R-Ras2. (204 aa) |
| | Eif4b | Eukaryotic translation initiation factor 4B. (599 aa) |
| | Wnt3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | ENSMAUP00000020165 | annotation not available (66 aa) |
| | Fgfr1 | Fibroblast growth factor receptor. (819 aa) |
| | Sdc2 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa) |
| | Wnt8b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | Frs2 | Fibroblast growth factor receptor substrate 2. (510 aa) |
| | Ccnd1 | G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa) |
| | Rac1 | Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa) |
| | Wnt9b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) |
| | Itga5 | Integrin alpha-5; Belongs to the integrin alpha chain family. (1058 aa) |
| | Rps6kb2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa) |
| | Kras | GTPase KRas isoform X3. (189 aa) |
| | 1110032A03Rik | UPF0686 protein C11orf1 homolog isoform X1. (183 aa) |
| | Mapk13 | Mitogen-activated protein kinase. (366 aa) |
| | Mapk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa) |
| | Tlr4 | Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa) |
| | Itpr1 | Inositol 1,4,5-trisphosphate receptor type 1 isoform X2. (2757 aa) |
| | Grb2 | Growth factor receptor-bound protein 2. (217 aa) |
| | Pik3r2 | Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa) |
| | Hoxd10 | Homeobox protein Hox-D10. (340 aa) |
| | Actrt1 | Actin-related protein T1; Belongs to the actin family. (376 aa) |
| | LOC101824912 | 40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (251 aa) |
| | Rps6 | Ribosomal protein S6. (131 aa) |
| | Wnt7a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (318 aa) |
| | Shh | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (439 aa) |
| | 4930544G11Rik | Transforming protein RhoA-like isoform X1. (193 aa) |
| | Akt3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | Kdr | Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1347 aa) |
| | Braf | Serine/threonine-protein kinase B-raf. (710 aa) |
| | Gpc1 | Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa) |
| | Ppp1ca | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | Mapk14 | Mitogen-activated protein kinase. (360 aa) |
| | LOC101835135 | Actin-like protein 9; Belongs to the actin family. (411 aa) |
| | Itgav | Integrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1045 aa) |
| | Itgb3 | Integrin beta; Belongs to the integrin beta chain family. (787 aa) |
| | Mtor | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | Ppp1r12b | Protein phosphatase 1 regulatory subunit. (186 aa) |
| | Raf1 | RAF proto-oncogene serine/threonine-protein kinase. (648 aa) |
| | Ppp1cb | Protein phosphatase 1 catalytic subunit beta. (298 aa) |
| | Wnt16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa) |
| | Rhoa | Transforming protein RhoA-like isoform X2. (141 aa) |
| | Ank3 | Ankyrin-3 isoform X20. (2626 aa) |
| | Lum | Lumican. (338 aa) |
| | Fzd8 | LOW QUALITY PROTEIN: frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (675 aa) |
| | Ptch1 | Protein patched homolog 1. (1440 aa) |
| | Ihh | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (363 aa) |
| | Hspb2 | Heat shock protein beta-2; Belongs to the small heat shock protein (HSP20) family. (182 aa) |
| | Hpse | Heparanase. (489 aa) |
| | Fgf2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa) |
| | Wnt5a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | Tnf | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | ENSMAUP00000014559 | annotation not available (224 aa) |
| | Rdx | Radixin. (564 aa) |
| | Csde1 | Cold shock domain-containing protein E1 isoform X3. (798 aa) |
| | ENSMAUP00000014169 | annotation not available (217 aa) |
| | Arhgef1 | Rho guanine nucleotide exchange factor 1. (648 aa) |
| | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta. (160 aa) |
| | LOC101842052 | filamin-A. (816 aa) |
| | Flnb | filamin-B isoform X1. (2602 aa) |
| | Ptpn11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa) |
| | ENSMAUP00000013721 | annotation not available (98 aa) |
| | Pxn | Paxillin; Belongs to the paxillin family. (589 aa) |
| | ENSMAUP00000013077 | annotation not available (450 aa) |
| | Sos2 | Son of sevenless homolog 2 isoform X1. (1308 aa) |
| | Prkcb | Protein kinase C beta. (554 aa) |
| | Arhgef12 | Rho guanine nucleotide exchange factor 12 isoform X1. (1544 aa) |
| | Akt1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | Itgb5 | Integrin beta 5. (579 aa) |
| | Met | Hepatocyte growth factor receptor. (1382 aa) |
| | Itpr2 | Inositol 1,4,5-trisphosphate receptor type 2. (2584 aa) |
| | ENSMAUP00000012407 | annotation not available (102 aa) |
| | ENSMAUP00000012402 | annotation not available (74 aa) |
| | ENSMAUP00000012061 | annotation not available (121 aa) |
| | Wnt2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa) |
| | Wnt1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | Elk1 | ETS domain-containing protein Elk-1. (426 aa) |
| | Mapk3 | Mitogen-activated protein kinase. (380 aa) |
| | Wnt10b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa) |
| | Pdcd4 | Programmed cell death protein 4. (469 aa) |
| | Map2k2 | Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | Rock1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa) |
| | ENSMAUP00000010883 | annotation not available (214 aa) |
| | Rhoc | Rho-related GTP-binding protein RhoC. (193 aa) |
| | Map2k1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | Wnt4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | Zscan2 | Zinc finger and SCAN domain-containing protein 2. (610 aa) |
| | Mras | Ras-related protein M-Ras. (208 aa) |
| | Igf1r | Tyrosine-protein kinase receptor. (1154 aa) |
| | Pak1 | P21 (RAC1) activated kinase 1. (490 aa) |
| | Lpxn | Leupaxin; Belongs to the paxillin family. (381 aa) |
| | Tiam1 | T-lymphoma invasion and metastasis-inducing protein 1. (1551 aa) |
| | Mmp2 | 72 kDa type IV collagenase. (662 aa) |
| | Fzd7 | Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (572 aa) |
| | Hspg2 | Basement membrane-specific heparan sulfate proteoglycan core protein. (3785 aa) |
| | Wnt8a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | Smo | Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (757 aa) |
| | Vav2 | Guanine nucleotide exchange factor VAV2 isoform X2. (868 aa) |
| | Tgfb2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | Wnt7b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | Actrt2 | Actin-related protein T2; Belongs to the actin family. (377 aa) |
| | Araf | Serine/threonine-protein kinase A-Raf isoform X2. (604 aa) |
| | Src | Tyrosine-protein kinase. (536 aa) |
| | Gab1 | GRB2-associated-binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. (665 aa) |
| | Fzd9 | Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa) |
| | Fas | Tumor necrosis factor receptor superfamily member 6 isoform X1. (323 aa) |
| | Prkca | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | Stat3 | Signal transducer and activator of transcription. (758 aa) |
| | Actb | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | Ddx5 | Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (615 aa) |
| | Ccdc170 | Coiled-coil domain-containing protein 170 isoform X1. (718 aa) |
| | Wnt11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | Vav3 | Guanine nucleotide exchange factor VAV3 isoform X1. (847 aa) |
| | Bmyc | Protein B-Myc. (173 aa) |
| | Cblb | E3 ubiquitin-protein ligase CBL-B. (972 aa) |
| | Pik3r1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | Iqgap1 | Ras GTPase-activating-like protein IQGAP1. (1657 aa) |
| | Pdpk1 | 3-phosphoinositide-dependent protein kinase 1 isoform X2. (559 aa) |
| | Itga2 | Integrin alpha-2; Belongs to the integrin alpha chain family. (1178 aa) |
| | Faslg | Tumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (279 aa) |
| | Fzd10 | Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa) |
| | Myc | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | Sdc1 | Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. (309 aa) |
| | Hgf | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa) |
