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| | Tnc | Tenascin isoform X2. (2170 aa) |
| | Zfpm2 | Zinc finger protein ZFPM2 isoform X1. (1156 aa) |
| | Tnxb | tenascin-X. (3445 aa) |
| | Gls2 | Glutaminase liver isoform, mitochondrial isoform X1. (602 aa) |
| | Ube2i | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451 (By similarity). Can catalyze the formation of poly-SUMO chains (By similarity). Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386' (By similarity). Mediates sumoylation of ERCC6 which is essential for its transcription-coupled [...] (158 aa) |
| | Pdgfra | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | Ptgs2 | Prostaglandin G/H synthase 2. (604 aa) |
| | Wnt3a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | Sos1 | Son of sevenless homolog 1. (1319 aa) |
| | Prkce | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (623 aa) |
| | Tpte | LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (670 aa) |
| | Slc7a1 | High affinity cationic amino acid transporter 1 isoform X1. (628 aa) |
| | Timp3 | Metalloproteinase inhibitor 3. (211 aa) |
| | Spry2 | Protein sprouty homolog 2. (320 aa) |
| | LOC101836687 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa) |
| | Hmox1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa) |
| | Zeb1 | Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'- CANNTG-3'). Promotes tumorige [...] (1043 aa) |
| | Egfr | Receptor protein-tyrosine kinase. (1207 aa) |
| | Tnr | tenascin-R isoform X1. (1358 aa) |
| | E2f1 | Transcription factor E2F1. (383 aa) |
| | Cdkn1a | Cyclin-dependent kinase inhibitor 1. (163 aa) |
| | Prkcg | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (612 aa) |
| | Plcg1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1293 aa) |
| | Sox4 | Transcription factor SOX. (439 aa) |
| | Stmn1 | Stathmin; Belongs to the stathmin family. (149 aa) |
| | Pdgfrb | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (703 aa) |
| | Mapk3 | Mitogen-activated protein kinase. (380 aa) |
| | Dnmt3a | DNA (Cytosine-5)-methyltransferase 3A isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (908 aa) |
| | Bmi1 | Polycomb complex protein BMI-1. (324 aa) |
| | Hdac1 | Histone deacetylase 1. (303 aa) |
| | Cyp1b1 | Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (541 aa) |
| | Fgfr3 | Fibroblast growth factor receptor. (802 aa) |
| | Trim71 | E3 ubiquitin-protein ligase TRIM71. (824 aa) |
| | Met | Hepatocyte growth factor receptor. (1382 aa) |
| | Mapk7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa) |
| | Prkcb | Protein kinase C beta. (554 aa) |
| | Sos2 | Son of sevenless homolog 2 isoform X1. (1308 aa) |
| | Cyp24a1 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (514 aa) |
| | Pdcd4 | Programmed cell death protein 4. (469 aa) |
| | Atm | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3014 aa) |
| | Notch1 | Neurogenic locus notch homolog protein 1 isoform X1. (2532 aa) |
| | Map2k2 | Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | Rock1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa) |
| | Ccne2 | G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa) |
| | Efna3 | ephrin-A3 isoform X1; Belongs to the ephrin family. (230 aa) |
| | Rhoc | Rho-related GTP-binding protein RhoC. (193 aa) |
| | Map2k1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | Rptor | Regulatory-associated protein of mTOR. (1282 aa) |
| | Bcl2 | Apoptosis regulator Bcl-2. (236 aa) |
| | Pdgfb | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (221 aa) |
| | Crebbp | CREB-binding protein. (2433 aa) |
| | Tgfb2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | Ddit4 | DNA damage-inducible transcript 4 protein. (227 aa) |
| | LOC101836961 | Serine/threonine-protein kinase pim-1. (313 aa) |
| | Dicer1 | Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily. (1917 aa) |
| | Kif23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (843 aa) |
| | St14 | Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa) |
| | Fscn2 | Fascin. (492 aa) |
| | LOC101842493 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (236 aa) |
| | Bcl2l11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (197 aa) |
| | Bmpr2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (832 aa) |
| | Ccng1 | cyclin-G1; Belongs to the cyclin family. (294 aa) |
| | Prkca | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | Stat3 | Signal transducer and activator of transcription. (758 aa) |
| | Ezh2 | Histone-lysine N-methyltransferase EZH2 isoform X2. (745 aa) |
| | Tp63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | ENSMAUP00000006643 | annotation not available (1305 aa) |
| | Sirt1 | NAD-dependent protein deacetylase sirtuin-1. (691 aa) |
| | Bmyc | Protein B-Myc. (173 aa) |
| | Pik3r1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | Myc | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | Plcg2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa) |
| | Ezr | Ezrin. (576 aa) |
| | Mcl1 | Induced myeloid leukemia cell differentiation protein Mcl-1. (279 aa) |
| | Vegfa | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (248 aa) |
| | Pik3cb | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | Pten | Phosphatase and tensin homolog. (403 aa) |
| | Mmp9 | Matrix metalloproteinase-9. (718 aa) |
| | Efna1 | ephrin-A1; Belongs to the ephrin family. (205 aa) |
| | Casp3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (246 aa) |
| | Vim | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa) |
| | Cd44 | CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its c [...] (431 aa) |
| | Ep300 | Histone acetyltransferase p300 isoform X3. (2417 aa) |
| | Serpinb5 | Serpin B5; Belongs to the serpin family. (375 aa) |
| | E2f2 | Transcription factor E2F2 isoform X1. (449 aa) |
| | Mmp16 | Matrix metalloproteinase-16. (607 aa) |
| | Eras | GTPase ERas. (228 aa) |
| | Cdkn2a | Cyclin-dependent kinase inhibitor 2A. (157 aa) |
| | Efna4 | ephrin-A4; Belongs to the ephrin family. (204 aa) |
| | Plau | Urokinase-type plasminogen activator. (433 aa) |
| | Ccne1 | G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa) |
| | LOC101831400 | Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa) |
| | ENSMAUP00000002714 | annotation not available (58 aa) |
| | Reck | Reversion-inducing cysteine-rich protein with Kazal motifs isoform X2. (969 aa) |
| | Bmf | Bcl-2-modifying factor isoform X1. (189 aa) |
| | Hdac5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1118 aa) |
| | Pik3cd | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | Gpsm3 | G-protein-signaling modulator 3. (116 aa) |
| | Cdc25b | M-phase inducer phosphatase 2. (575 aa) |
| | Apc | Adenomatous polyposis coli protein isoform X4. (492 aa) |
| | Cep152 | Centrosomal protein of 152 kDa. (1691 aa) |
| | Csde1 | Cold shock domain-containing protein E1 isoform X3. (798 aa) |
| | Rps6ka5 | Ribosomal protein S6 kinase. (849 aa) |
| | Cdca5 | Sororin. (248 aa) |
| | Rdx | Radixin. (564 aa) |
| | ENSMAUP00000014414 | annotation not available (313 aa) |
| | ENSMAUP00000014706 | annotation not available (414 aa) |
| | Marcks | Myristoylated alanine-rich C-kinase substrate. (195 aa) |
| | Slc45a3 | Solute carrier family 45 member 3. (231 aa) |
| | Irs1 | Insulin receptor substrate 1. (1233 aa) |
| | Cdkn1b | Cyclin-dependent kinase inhibitor 1B. (198 aa) |
| | Wnt3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | Bak1 | Bcl-2 homologous antagonist/killer. (209 aa) |
| | Nfkb1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa) |
| | ENSMAUP00000019554 | annotation not available (231 aa) |
| | Ccnd1 | G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa) |
| | Itga5 | Integrin alpha-5; Belongs to the integrin alpha chain family. (1058 aa) |
| | Kras | GTPase KRas isoform X3. (189 aa) |
| | Rassf1 | Ras association domain-containing protein 1. (340 aa) |
| | Mapk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa) |
| | Grb2 | Growth factor receptor-bound protein 2. (217 aa) |
| | Pik3r2 | Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa) |
| | Ccnd2 | G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa) |
| | Hmga2 | High mobility group protein HMGI-C isoform X1. (108 aa) |
| | Hoxd10 | Homeobox protein Hox-D10. (340 aa) |
| | Crkl | Crk-like protein. (303 aa) |
| | Notch2 | Neurogenic locus notch homolog protein 2. (2470 aa) |
| | 4930544G11Rik | Transforming protein RhoA-like isoform X1. (193 aa) |
| | Efna5 | ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa) |
| | Sox12 | Transcription factor SOX. (300 aa) |
| | Notch4 | Neurogenic locus notch homolog protein 4. (1949 aa) |
| | Tpm1 | Tropomyosin alpha-1 chain isoform X7; Belongs to the tropomyosin family. (326 aa) |
| | Socs1 | Suppressor of cytokine signaling 1. (212 aa) |
| | Itgb3 | Integrin beta; Belongs to the integrin beta chain family. (787 aa) |
| | Mtor | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | Raf1 | RAF proto-oncogene serine/threonine-protein kinase. (648 aa) |
| | Zeb2 | Zinc finger E-box-binding homeobox 2 isoform X1. (1214 aa) |
| | Hnrnpk | Heterogeneous nuclear ribonucleoprotein K. (484 aa) |
| | Rhoa | Transforming protein RhoA-like isoform X2. (141 aa) |
| | Ikbkb | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (757 aa) |
| | Tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa) |
| | Efna2 | ephrin-A2; Belongs to the ephrin family. (209 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa) |
| | Foxp1 | Forkhead box protein P1 isoform X4. (694 aa) |
| | Tnn | tenascin-N. (1436 aa) |
| | Notch3 | Neurogenic locus notch homolog protein 3. (2268 aa) |
| | Apc2 | Adenomatous polyposis coli protein 2 isoform X3. (2286 aa) |
| | Adam15 | Disintegrin and metalloproteinase domain-containing protein 15 isoform X3. (888 aa) |
| | Cdc25c | Cell division cycle 25C. (271 aa) |
| | Abcc1 | Multidrug resistance-associated protein 1 isoform X1. (1269 aa) |
| | Pdgfa | Platelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa) |
| | Hdac4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa) |
| | Fscn1 | Fascin. (493 aa) |
| | Erbb2 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1247 aa) |
| | Pik3r2-2 | Phosphoinositide-3-kinase regulatory subunit 2. (71 aa) |
| | Cdk6 | Cyclin-dependent kinase 6. (203 aa) |
| | Thbs1 | Thrombospondin-1 isoform X1. (1171 aa) |
| | Shc4 | SHC adaptor protein 4. (204 aa) |
| | Crk | Adapter molecule crk isoform X1. (304 aa) |
| | Fzd3 | Frizzled-3 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | Gls | Glutaminase kidney isoform, mitochondrial isoform X1. (671 aa) |
| | Irs2 | Insulin receptor substrate 2. (1333 aa) |
| | Hdac2 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa) |
| | Pak4 | Non-specific serine/threonine protein kinase. (592 aa) |
| | Hras | GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa) |
| | Nras | NRAS proto-oncogene, GTPase. (98 aa) |
| | Shc1 | SHC-transforming protein 1 isoform X1. (579 aa) |
| | Pik3ca | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | E2f3 | Transcription factor E2F3 isoform X1. (460 aa) |
| | Dnmt1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1599 aa) |
