STRINGSTRING
Akt1 Akt1 Gadd45a Gadd45a ENSMAUP00000012402 ENSMAUP00000012402 Mapk3 Mapk3 Map2k1 Map2k1 Cdk4 Cdk4 ENSMAUP00000009408 ENSMAUP00000009408 Ddb2 Ddb2 Tgfb2 Tgfb2 Araf Araf Jak1 Jak1 Smad4 Smad4 Stat3 Stat3 Rala Rala Ikbkg Ikbkg Pik3r1 Pik3r1 Arhgef6 Arhgef6 Vegfa Vegfa Pik3cb Pik3cb Smad2 Smad2 Mapk8 Mapk8 Tgfb3 Tgfb3 Cdc42 Cdc42 E2f2 E2f2 Bcl2l1 Bcl2l1 Tgfb1 Tgfb1 Cdkn2a Cdkn2a LOC101831400 LOC101831400 Dhdh Dhdh Tgfbr2 Tgfbr2 Pik3cd Pik3cd Cdkn1a Cdkn1a Rac3 Rac3 E2f1 E2f1 Egfr Egfr Smad3 Smad3 Tp53 Tp53 Erbb2 Erbb2 Pik3r2-2 Pik3r2-2 Cdk6 Cdk6 Pld1 Pld1 Rb1 Rb1 Akt2 Akt2 Gadd45g Gadd45g Nras Nras Pik3ca Pik3ca Brca2 Brca2 E2f3 E2f3 Rad51 Rad51 Pld2 Pld2 Ralgds Ralgds Bak1 Bak1 Nfkb1 Nfkb1 Tgfa Tgfa Ccnd1 Ccnd1 Rac1 Rac1 Rps6kb2 Rps6kb2 Kras Kras Chuk Chuk Mapk9 Mapk9 Mapk1 Mapk1 Mapk10 Mapk10 Pik3r2 Pik3r2 Rac2 Rac2 Polk Polk Akt3 Akt3 Braf Braf Mtor Mtor Egf Egf Raf1 Raf1 Rela Rela Bax Bax Gadd45b Gadd45b Stat1 Stat1 Ikbkb Ikbkb ENSMAUP00000015128 ENSMAUP00000015128 Casp9 Casp9 Bad Bad Ralbp1 Ralbp1 Tgfbr1 Tgfbr1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
ENSMAUP00000012402annotation not available (74 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ENSMAUP00000009408annotation not available (808 aa)
Ddb2DNA damage-binding protein 2 isoform X1. (387 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ArafSerine/threonine-protein kinase A-Raf isoform X2. (604 aa)
Jak1Tyrosine-protein kinase. (1161 aa)
Smad4Mothers against decapentaplegic homolog. (552 aa)
Stat3Signal transducer and activator of transcription. (758 aa)
RalaRas-related protein Ral-A. (206 aa)
IkbkgNF-kappa-B essential modulator isoform X1. (412 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Arhgef6LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 6. (302 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (248 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Cdc42Cell division control protein 42 homolog isoform X1. (191 aa)
E2f2Transcription factor E2F2 isoform X1. (449 aa)
Bcl2l1Bcl-2-like protein 1. (233 aa)
Tgfb1Transforming growth factor beta-1. (286 aa)
Cdkn2aCyclin-dependent kinase inhibitor 2A. (157 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
DhdhTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (297 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (163 aa)
Rac3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
E2f1Transcription factor E2F1. (383 aa)
EgfrReceptor protein-tyrosine kinase. (1207 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
Erbb2Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1247 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Cdk6Cyclin-dependent kinase 6. (203 aa)
Pld1Phospholipase. (849 aa)
Rb1Retinoblastoma-associated protein. (906 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Brca2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (1176 aa)
E2f3Transcription factor E2F3 isoform X1. (460 aa)
Rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (187 aa)
Pld2Phospholipase. (933 aa)
RalgdsRal guanine nucleotide dissociation stimulator. (893 aa)
Bak1Bcl-2 homologous antagonist/killer. (209 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
TgfaProtransforming growth factor alpha. (159 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Rac1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
KrasGTPase KRas isoform X3. (189 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Rac2Ras-related C3 botulinum toxin substrate 2. (192 aa)
PolkDNA polymerase kappa. (856 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BrafSerine/threonine-protein kinase B-raf. (710 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (254 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
BaxApoptosis regulator BAX isoform X1. (192 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (757 aa)
ENSMAUP00000015128annotation not available (114 aa)
Casp9Caspase-9; Belongs to the peptidase C14A family. (440 aa)
BadBcl2-associated agonist of cell death isoform X1. (204 aa)
Ralbp1ralA-binding protein 1. (643 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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