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Pik3r1 Pik3r1 Pdgfa Pdgfa Pik3r2-2 Pik3r2-2 Cdk6 Cdk6 Rb1 Rb1 Akt2 Akt2 Igf1 Igf1 Fgf6 Fgf6 Gadd45g Gadd45g Hras Hras Nras Nras Pik3ca Pik3ca E2f3 E2f3 Fgf9 Fgf9 Pdgfra Pdgfra Fgf4 Fgf4 Fgf19 Fgf19 Fgf16 Fgf16 Bak1 Bak1 Fgfr1 Fgfr1 Ccnd1 Ccnd1 Fgf3 Fgf3 Kras Kras Mapk1 Mapk1 Pik3r2 Pik3r2 Fgf5 Fgf5 Polk Polk Fgf8 Fgf8 Fgf21 Fgf21 Akt3 Akt3 Braf Braf Fgf22 Fgf22 Egf Egf Raf1 Raf1 Bax Bax Gadd45b Gadd45b Cdh1 Cdh1 Pdgfc Pdgfc Fgf17 Fgf17 ENSMAUP00000015128 ENSMAUP00000015128 Fgf2 Fgf2 Csde1 Csde1 Fgf7 Fgf7 Bad Bad Akt1 Akt1 Gadd45a Gadd45a Met Met Pdgfd Pdgfd Mapk3 Mapk3 Pdgfrb Pdgfrb Fgf10 Fgf10 Fgf1 Fgf1 Map2k2 Map2k2 Map2k1 Map2k1 Fgf20 Fgf20 Pdgfb Pdgfb Igf1r Igf1r Cdk4 Cdk4 Ddb2 Ddb2 Araf Araf Pten Pten Pik3cb Pik3cb Hgf Hgf Cdkn2a Cdkn2a Fgf23 Fgf23 Eras Eras E2f2 E2f2 Mitf Mitf Galk2 Galk2 LOC101831400 LOC101831400 Dhdh Dhdh Pik3cd Pik3cd Cdkn1a Cdkn1a E2f1 E2f1 Egfr Egfr Fgf18 Fgf18 Tpte Tpte Tp53 Tp53 MDM2 MDM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PdgfaPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Cdk6Cyclin-dependent kinase 6. (203 aa)
Rb1Retinoblastoma-associated protein. (906 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Igf1Insulin-like growth factor 1. (153 aa)
Fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
E2f3Transcription factor E2F3 isoform X1. (460 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
Fgf19Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (215 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Bak1Bcl-2 homologous antagonist/killer. (209 aa)
Fgfr1Fibroblast growth factor receptor. (819 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
KrasGTPase KRas isoform X3. (189 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
PolkDNA polymerase kappa. (856 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
Fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BrafSerine/threonine-protein kinase B-raf. (710 aa)
Fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (162 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (254 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
BaxApoptosis regulator BAX isoform X1. (192 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
Cdh1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
PdgfcPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
ENSMAUP00000015128annotation not available (114 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
BadBcl2-associated agonist of cell death isoform X1. (204 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
MetHepatocyte growth factor receptor. (1382 aa)
PdgfdPlatelet-derived growth factor D. (313 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
PdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (703 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Fgf1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (155 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (221 aa)
Igf1rTyrosine-protein kinase receptor. (1154 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Ddb2DNA damage-binding protein 2 isoform X1. (387 aa)
ArafSerine/threonine-protein kinase A-Raf isoform X2. (604 aa)
PtenPhosphatase and tensin homolog. (403 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
Cdkn2aCyclin-dependent kinase inhibitor 2A. (157 aa)
Fgf23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
ErasGTPase ERas. (228 aa)
E2f2Transcription factor E2F2 isoform X1. (449 aa)
MitfMicrophthalmia-associated transcription factor isoform X1. (526 aa)
Galk2N-acetylgalactosamine kinase isoform X4. (334 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
DhdhTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (297 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (163 aa)
E2f1Transcription factor E2F1. (383 aa)
EgfrReceptor protein-tyrosine kinase. (1207 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TpteLOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (670 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (270 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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