STRINGSTRING
ENSMAUP00000015128 ENSMAUP00000015128 Gadd45b Gadd45b Bax Bax Raf1 Raf1 Egf Egf Braf Braf Akt3 Akt3 Polk Polk E2f1 E2f1 Cdkn1a Cdkn1a Prkcg Prkcg Plcg1 Plcg1 Pik3cd Pik3cd LOC101835654 LOC101835654 Ltk Ltk Dhdh Dhdh ENSMAUP00000002714 ENSMAUP00000002714 LOC101831400 LOC101831400 Cdkn2a Cdkn2a Rassf5 Rassf5 Eras Eras E2f2 E2f2 LOC101842510 LOC101842510 Pik3cb Pik3cb Plcg2 Plcg2 Hgf Hgf Fhit Fhit Pdpk1 Pdpk1 Pik3r1 Pik3r1 Stat3 Stat3 Prkca Prkca Rxrb Rxrb Alk Alk Araf Araf Ddb2 Ddb2 Jak3 Jak3 Cdk4 Cdk4 Map2k1 Map2k1 Map2k2 Map2k2 Mapk3 Mapk3 LOC110339561 LOC110339561 Met Met Gadd45a Gadd45a Akt1 Akt1 Prkcb Prkcb Sos2 Sos2 Rxra Rxra Pik3r2 Pik3r2 Grb2 Grb2 Mapk1 Mapk1 Rassf1 Rassf1 Kras Kras Ccnd1 Ccnd1 Tgfa Tgfa Bak1 Bak1 Stk4 Stk4 Rxrg Rxrg E2f3 E2f3 Pik3ca Pik3ca Nras Nras Hras Hras Gadd45g Gadd45g Akt2 Akt2 Rb1 Rb1 Cdk6 Cdk6 Pik3r2-2 Pik3r2-2 Erbb2 Erbb2 Tp53 Tp53 Rarb Rarb Egfr Egfr Sos1 Sos1 Eml4 Eml4 Bad Bad Foxo3 Foxo3 Csde1 Csde1 Casp9 Casp9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMAUP00000015128annotation not available (114 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
BaxApoptosis regulator BAX isoform X1. (192 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (254 aa)
BrafSerine/threonine-protein kinase B-raf. (710 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PolkDNA polymerase kappa. (856 aa)
E2f1Transcription factor E2F1. (383 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (163 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (612 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1293 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC101835654Signal transducer and activator of transcription. (228 aa)
LtkTyrosine-protein kinase receptor. (835 aa)
DhdhTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (297 aa)
ENSMAUP00000002714annotation not available (58 aa)
LOC101831400Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa)
Cdkn2aCyclin-dependent kinase inhibitor 2A. (157 aa)
Rassf5Ras association domain-containing protein 5 isoform X2. (265 aa)
ErasGTPase ERas. (228 aa)
E2f2Transcription factor E2F2 isoform X1. (449 aa)
LOC101842510Signal transducer and activator of transcription 5A. (228 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
Plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
FhitBis(5'-adenosyl)-triphosphatase. (124 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X2. (559 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Stat3Signal transducer and activator of transcription. (758 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
RxrbRetinoic acid receptor RXR-beta. (414 aa)
AlkTyrosine-protein kinase receptor. (1573 aa)
ArafSerine/threonine-protein kinase A-Raf isoform X2. (604 aa)
Ddb2DNA damage-binding protein 2 isoform X1. (387 aa)
Jak3Tyrosine-protein kinase. (1080 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
LOC110339561Signal transducer and activator of transcription 5B-like. (125 aa)
MetHepatocyte growth factor receptor. (1382 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PrkcbProtein kinase C beta. (554 aa)
Sos2Son of sevenless homolog 2 isoform X1. (1308 aa)
RxraRetinoic acid receptor RXR-alpha. (457 aa)
Pik3r2Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Rassf1Ras association domain-containing protein 1. (340 aa)
KrasGTPase KRas isoform X3. (189 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
TgfaProtransforming growth factor alpha. (159 aa)
Bak1Bcl-2 homologous antagonist/killer. (209 aa)
Stk4Serine/threonine-protein kinase 4. (448 aa)
RxrgRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
E2f3Transcription factor E2F3 isoform X1. (460 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NrasNRAS proto-oncogene, GTPase. (98 aa)
HrasGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Rb1Retinoblastoma-associated protein. (906 aa)
Cdk6Cyclin-dependent kinase 6. (203 aa)
Pik3r2-2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
Erbb2Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1247 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa)
RarbRetinoic acid receptor beta-2. (448 aa)
EgfrReceptor protein-tyrosine kinase. (1207 aa)
Sos1Son of sevenless homolog 1. (1319 aa)
Eml4EMAP like 4. (751 aa)
BadBcl2-associated agonist of cell death isoform X1. (204 aa)
Foxo3Forkhead box protein O3. (672 aa)
Csde1Cold shock domain-containing protein E1 isoform X3. (798 aa)
Casp9Caspase-9; Belongs to the peptidase C14A family. (440 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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