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| | Heyl | Hairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (328 aa) |
| | Apc2 | Adenomatous polyposis coli protein 2 isoform X3. (2286 aa) |
| | Wnt9a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (191 aa) |
| | Wnt5b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa) |
| | Wnt3a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | Dll4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (686 aa) |
| | Erbb2 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1247 aa) |
| | Pik3r2-2 | Phosphoinositide-3-kinase regulatory subunit 2. (71 aa) |
| | Cdk6 | Cyclin-dependent kinase 6. (203 aa) |
| | Shc4 | SHC adaptor protein 4. (204 aa) |
| | Rb1 | Retinoblastoma-associated protein. (906 aa) |
| | Akt2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | Igf1 | Insulin-like growth factor 1. (153 aa) |
| | Fzd3 | Frizzled-3 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | Dvl1 | Segment polarity protein dishevelled homolog DVL-1 isoform X1. (695 aa) |
| | Fgf6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | Gadd45g | Growth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa) |
| | Hras | GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa) |
| | Nras | NRAS proto-oncogene, GTPase. (98 aa) |
| | Shc1 | SHC-transforming protein 1 isoform X1. (579 aa) |
| | Pik3ca | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | Brca2 | LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (1176 aa) |
| | Hes5 | Transcription factor HES-5. (166 aa) |
| | E2f3 | Transcription factor E2F3 isoform X1. (460 aa) |
| | Fos | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa) |
| | Esr2 | Estrogen receptor beta. (305 aa) |
| | Fgf9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | Pgr | Progesterone receptor. (927 aa) |
| | LOC101827846 | Coiled-coil domain-containing protein 170-like. (352 aa) |
| | Frat1 | Proto-oncogene FRAT1. (192 aa) |
| | Dvl3 | Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa) |
| | Fgf4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa) |
| | Fgf19 | Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (215 aa) |
| | Fgf16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | Sp1 | Transcription factor Sp1 isoform X1. (786 aa) |
| | Wnt3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | Bak1 | Bcl-2 homologous antagonist/killer. (209 aa) |
| | Hey1 | Hairy/enhancer-of-split related with YRPW motif protein 1. (278 aa) |
| | Fgfr1 | Fibroblast growth factor receptor. (819 aa) |
| | Lrp5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa) |
| | Wnt8b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | Ccnd1 | G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa) |
| | Fgf3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa) |
| | Wnt9b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) |
| | Rps6kb2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa) |
| | Kras | GTPase KRas isoform X3. (189 aa) |
| | Mapk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa) |
| | Grb2 | Growth factor receptor-bound protein 2. (217 aa) |
| | Pik3r2 | Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa) |
| | Fgf5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa) |
| | Ncoa1 | Nuclear receptor coactivator. (1444 aa) |
| | Notch2 | Neurogenic locus notch homolog protein 2. (2470 aa) |
| | Polk | DNA polymerase kappa. (856 aa) |
| | Wnt7a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (318 aa) |
| | Fgf8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa) |
| | Fgf21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | Nfkb2 | Nuclear factor NF-kappa-B p100 subunit isoform X2. (898 aa) |
| | Akt3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | Braf | Serine/threonine-protein kinase B-raf. (710 aa) |
| | Fgf22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (162 aa) |
| | Notch4 | Neurogenic locus notch homolog protein 4. (1949 aa) |
| | Gsk3b | Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (429 aa) |
| | Tcf7l1 | Transcription factor 7-like 1. (558 aa) |
| | Mtor | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | Egf | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (254 aa) |
| | Raf1 | RAF proto-oncogene serine/threonine-protein kinase. (648 aa) |
| | Jag1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | Bax | Apoptosis regulator BAX isoform X1. (192 aa) |
| | Gadd45b | Growth arrest and DNA damage-inducible protein GADD45 beta. (160 aa) |
| | Wnt16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa) |
| | Pik3r1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | Axin1 | Axin-1 isoform X1. (868 aa) |
| | Fzd10 | Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa) |
| | Myc | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | Shc2 | SHC-transforming protein 2. (573 aa) |
| | Axin2 | Axin-2. (70 aa) |
| | Jun | Transcription factor AP-1; Belongs to the bZIP family. (338 aa) |
| | Pik3cb | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | Esr1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | Pten | Phosphatase and tensin homolog. (403 aa) |
| | Lef1 | Lymphoid enhancer-binding factor 1 isoform X2. (397 aa) |
| | Wnt2b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa) |
| | Galk2 | N-acetylgalactosamine kinase isoform X4. (334 aa) |
| | E2f2 | Transcription factor E2F2 isoform X1. (449 aa) |
| | Eras | GTPase ERas. (228 aa) |
| | LOC101831400 | Phosphatidylinositol 3-kinase regulatory subunit gamma. (430 aa) |
| | Jag2 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1225 aa) |
| | Wnt10a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (418 aa) |
| | Dhdh | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (297 aa) |
| | Fgf17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa) |
| | Fzd8 | LOW QUALITY PROTEIN: frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (675 aa) |
| | Fgf2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa) |
| | Wnt5a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | Tcf7l2 | Transcription factor 7-like 2 isoform X17. (598 aa) |
| | Flt4 | Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa) |
| | Csde1 | Cold shock domain-containing protein E1 isoform X3. (798 aa) |
| | Kit | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa) |
| | Cep152 | Centrosomal protein of 152 kDa. (1691 aa) |
| | Fgf7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | Apc | Adenomatous polyposis coli protein isoform X4. (492 aa) |
| | Ncoa7 | Nuclear receptor coactivator 7 isoform X3. (221 aa) |
| | Gpsm3 | G-protein-signaling modulator 3. (116 aa) |
| | Hes1 | Transcription factor HES-1. (281 aa) |
| | Sos2 | Son of sevenless homolog 2 isoform X1. (1308 aa) |
| | Akt1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | Gadd45a | Growth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa) |
| | ENSMAUP00000012402 | annotation not available (74 aa) |
| | Dll1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (733 aa) |
| | Wnt2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa) |
| | Tcf7 | Transcription factor 7 isoform X3. (303 aa) |
| | Wnt1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | Mapk3 | Mitogen-activated protein kinase. (380 aa) |
| | Wnt10b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa) |
| | Fgf10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | Fgf1 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (155 aa) |
| | Notch1 | Neurogenic locus notch homolog protein 1 isoform X1. (2532 aa) |
| | Map2k2 | Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | Dll3 | Delta-like protein 3. (613 aa) |
| | Map2k1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | Wnt4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | Hey2 | Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa) |
| | Fgf20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa) |
| | ENSMAUP00000009932 | annotation not available (203 aa) |
| | Igf1r | Tyrosine-protein kinase receptor. (1154 aa) |
| | Cdk4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | Ncoa3 | Nuclear receptor coactivator. (1409 aa) |
| | ENSMAUP00000009408 | annotation not available (808 aa) |
| | Shc3 | SHC-transforming protein 3. (595 aa) |
| | Fzd7 | Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (572 aa) |
| | Lrp6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1601 aa) |
| | Wnt8a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | Ddb2 | DNA damage-binding protein 2 isoform X1. (387 aa) |
| | Wnt7b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | Araf | Serine/threonine-protein kinase A-Raf isoform X2. (604 aa) |
| | Fzd9 | Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa) |
| | Fgf23 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa) |
| | Ccdc170 | Coiled-coil domain-containing protein 170 isoform X1. (718 aa) |
| | ENSMAUP00000006643 | annotation not available (1305 aa) |
| | Wnt11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | Bmyc | Protein B-Myc. (173 aa) |
| | Fzd6 | Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (684 aa) |
| | Sos1 | Son of sevenless homolog 1. (1319 aa) |
| | Tpte | LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (670 aa) |
| | Fzd4 | Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (535 aa) |
| | Fzd1 | Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa) |
| | Dvl2 | Segment polarity protein dishevelled homolog DVL-2. (299 aa) |
| | Fgf18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | Egfr | Receptor protein-tyrosine kinase. (1207 aa) |
| | E2f1 | Transcription factor E2F1. (383 aa) |
| | Cdkn1a | Cyclin-dependent kinase inhibitor 1. (163 aa) |
| | Tnfsf11 | Tumor necrosis factor ligand superfamily member. (318 aa) |
| | Csnk1a1 | Casein kinase I isoform X3; Belongs to the protein kinase superfamily. (336 aa) |
| | Ctnnb1 | Catenin beta-1. (781 aa) |
| | Pik3cd | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | Wnt6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | Tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (395 aa) |
| | Fzd5 | Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa) |
| | Fzd2 | Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (567 aa) |
| | Notch3 | Neurogenic locus notch homolog protein 3. (2268 aa) |
