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PT7_0377 PT7_0377 PT7_1208 PT7_1208 leuB leuB leuD leuD leuC leuC PT7_1534 PT7_1534 PT7_1553 PT7_1553 PT7_1599 PT7_1599 PT7_1600 PT7_1600 PT7_1604 PT7_1604 PT7_1613 PT7_1613 ilvC ilvC PT7_1893 PT7_1893 PT7_1894 PT7_1894 ilvE ilvE PT7_2006 PT7_2006 PT7_2038 PT7_2038 PT7_2167 PT7_2167 PT7_2171 PT7_2171 leuD-2 leuD-2 PT7_2317 PT7_2317 ilvD ilvD PT7_2540 PT7_2540 ilvD-2 ilvD-2 PT7_2652 PT7_2652 PT7_2699 PT7_2699 PT7_2700 PT7_2700 PT7_2701 PT7_2701 PT7_2703 PT7_2703 PT7_2704 PT7_2704 PT7_2965 PT7_2965 PT7_2967 PT7_2967 PT7_3015 PT7_3015 PT7_3041 PT7_3041 leuA leuA PT7_3203 PT7_3203 ilvA ilvA PT7_3550 PT7_3550 PT7_3558 PT7_3558 PT7_3601 PT7_3601 PT7_3604 PT7_3604
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PT7_0377Hypothetical protein. (386 aa)
PT7_12083-isopropylmalate dehydrogenase. (356 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (358 aa)
leuDIsopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
PT7_1534Putative oxidoreductase. (470 aa)
PT7_1553Tartrate dehydrogenase. (355 aa)
PT7_1599Hypothetical protein. (523 aa)
PT7_1600Hypothetical protein. (334 aa)
PT7_1604Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (541 aa)
PT7_1613Hypothetical protein. (515 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
PT7_1893Acetolactate synthase 3 regulatory subunit. (163 aa)
PT7_1894Acetolactate synthase isozyme III large subunit. (573 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa)
PT7_2006Serine/threonine dehydratase. (322 aa)
PT7_2038Acetolactate synthase 2 catalytic subunit; Belongs to the TPP enzyme family. (589 aa)
PT7_2167Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (594 aa)
PT7_2171Hypothetical protein. (390 aa)
leuD-23-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (215 aa)
PT7_2317Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (561 aa)
PT7_2540Putative pyruvate decarboxylase; Belongs to the TPP enzyme family. (555 aa)
ilvD-2Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (579 aa)
PT7_2652L-lactate dehydrogenase. (402 aa)
PT7_2699Hypothetical protein. (320 aa)
PT7_2700acetoacetyl-CoA reductase. (250 aa)
PT7_2701Acetolactate synthase catalytic subunit; Belongs to the TPP enzyme family. (579 aa)
PT7_2703Hypothetical protein. (45 aa)
PT7_2704Putative hydrolase. (308 aa)
PT7_2965DNA-3-methyladenine glycosidase I. (201 aa)
PT7_2967Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (581 aa)
PT7_3015Acetolactate synthase large subunit. (581 aa)
PT7_3041Thiamine pyrophosphate binding domain-containing protein; Belongs to the TPP enzyme family. (569 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (567 aa)
PT7_3203Hypothetical protein. (224 aa)
ilvAThreonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (502 aa)
PT7_3550FAD linked oxidase-like protein. (462 aa)
PT7_3558Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (580 aa)
PT7_3601Thiamine pyrophosphate protein; Belongs to the TPP enzyme family. (574 aa)
PT7_3604L-lactate cytochrome c reductase. (396 aa)
Your Current Organism:
Pusillimonas sp. T77
NCBI taxonomy Id: 1007105
Other names: P. sp. T7-7, Pusillimonas sp. T7-7
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