(84 nodes) Neural crest cell development network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Anxa6	Annexin A6 isoform X1. (673 aa)
	Efnb1	Ephrin-B1 isoform X1. (345 aa)
	Sema3f	Semaphorin-3F isoform X1. (785 aa)
	Sema3b	Semaphorin-3B. (172 aa)
	Aldh1a2	Retinal dehydrogenase 2. (518 aa)
	Sema7a	Semaphorin-7A. (664 aa)
	Nrp1	Neuropilin-1 isoform X1. (923 aa)
	Foxc2	Forkhead box protein C2. (494 aa)
	Ednra	Endothelin receptor type A. (427 aa)
	Hand2	Heart- and neural crest derivatives-expressed protein 2. (217 aa)
	Fgf15	Fibroblast growth factor 19. (218 aa)
	Mapk3	Mitogen-activated protein kinase 1/3. (380 aa)
	Folr1	Folate receptor alpha. (255 aa)
	Sema4b	Semaphorin-4B. (824 aa)
	MGP_CAROLIEiJ_P0075713	annotation not available (1024 aa)
	Kbtbd8	Kelch repeat and BTB domain-containing protein 8 isoform X1. (599 aa)
	Sema4f	Semaphorin-4F isoform X1. (777 aa)
	Smo	Smoothened homolog. (793 aa)
	Bmpr1a	Bone morphogenetic protein receptor type-1A. (532 aa)
	Radil	Ras-associating and dilute domain-containing protein. (1099 aa)
	Coro1c	Coronin-1B/1C/6. (474 aa)
	Phox2b	Paired mesoderm homeobox protein 2B. (314 aa)
	Tapt1	Transmembrane anterior posterior transformation protein 1 homolog isoform X1. (564 aa)
	Shh	Sonic hedgehog protein isoform X1. (438 aa)
	Sema3c	Semaphorin-3C. (752 aa)
	Sema3e	Semaphorin-3E. (775 aa)
	Sema3a	Semaphorin-3A. (772 aa)
	Sema3d	Semaphorin-3D. (777 aa)
	Sema3g	Semaphorin-3G isoform X1. (780 aa)
	Isl1	Insulin gene enhancer protein ISL-1 isoform X1. (349 aa)
	Fam172a	Protein FAM172A. (437 aa)
	Sema4d	Semaphorin-4D isoform X1. (859 aa)
	Edn1	Endothelin-1. (202 aa)
	Tfap2a	Transcription factor AP-2-alpha isoform X1. (440 aa)
	Foxc1	Forkhead box protein C1. (553 aa)
	Hif1a	Hypoxia-inducible factor 1-alpha isoform X1. (839 aa)
	Twist1	Twist-related protein 1. (206 aa)
	Sox11	Transcription factor SOX11/12 (SOX group C). (395 aa)
	Sox9	Transcription factor SOX9 (SOX group E). (507 aa)
	Alx1	Cartilage homeoprotein 1. (326 aa)
	Kitl	Kit ligand isoform X1. (273 aa)
	Cited2	Cbp/p300-interacting transactivator 2. (269 aa)
	Klhl12	Kelch-like protein 12 isoform X1. (568 aa)
	Gbx2	Homeobox protein GBX-2 isoform X1. (348 aa)
	Htr2b	5-hydroxytryptamine receptor 2B. (479 aa)
	Pax3	Paired box protein Pax-3 isoform X1. (484 aa)
	Fn1	Fibronectin 1. (2477 aa)
	Erbb4	Receptor tyrosine-protein kinase erbB-4 isoform X1. (1308 aa)
	Nrp2	Neuropilin-2 isoform X1. (931 aa)
	Sema4c	Semaphorin-4C. (834 aa)
	Rdh10	Retinol dehydrogenase 10. (341 aa)
	Cdc42	Cell division control protein 42 homolog isoform X1. (191 aa)
	Phactr4	Phosphatase and actin regulator 4. (681 aa)
	Pef1	Peflin. (275 aa)
	Pitx2	Paired-like homeodomain transcription factor 2. (324 aa)
	Sema6c	Semaphorin-6C isoform X1. (932 aa)
	Sema4a	Semaphorin-4A. (760 aa)
	Lama5	Laminin subunit alpha-5. (3264 aa)
	Edn3	Endothelin-3. (214 aa)
	Ovol2	Transcription factor Ovo-like 2 isoform X1. (274 aa)
	Jag1	Protein jagged-1. (1218 aa)
	Sema6d	Semaphorin-6D isoform X1. (1069 aa)
	Pax6	Paired box protein Pax-6 isoform X1. (436 aa)
	Acvr1	Activin receptor type-1. (509 aa)
	Zeb2	Zinc finger E-box-binding homeobox 2. (1259 aa)
	Nolc1	Nucleolar and coiled-body phosphoprotein 1 isoform X1. (711 aa)
	Cyp26a1	Cytochrome P450 family 26 subfamily A. (497 aa)
	Cyp26c1	Cytochrome P450 family 26 subfamily C. (518 aa)
	Cfl1	Cofilin-1. (166 aa)
	Tcof1	Treacher Collins syndrome protein. (1375 aa)
	Sema6a	Semaphorin-6A isoform X1. (1048 aa)
	Cdh2	Cadherin 2, type 1, N-cadherin. (906 aa)
	Nrtn	Neurturin isoform X1. (195 aa)
	Sema6b	Semaphorin-6B isoform X1. (886 aa)
	Sox8	Transcription factor SOX7/8/10/18 (SOX group E/F). (464 aa)
	Sema5b	Semaphorin-5B. (1093 aa)
	Hes1	Hairy and enhancer of split 1. (281 aa)
	Tbx1	T-box transcription factor TBX1 isoform X1. (488 aa)
	Mapk1	Mitogen-activated protein kinase 1/3. (358 aa)
	Snai2	Zinc finger protein SNAI2. (269 aa)
	Sox10	Transcription factor SOX7/8/10/18 (SOX group E/F). (466 aa)
	Sema5a	Semaphorin-5A. (1074 aa)
	Gdnf	Glial cell line-derived neurotrophic factor isoform X1. (240 aa)
	Ednrb	Endothelin receptor type B. (442 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acvr1	Bmpr1a	MGP_CAROLIEiJ_P0051832	MGP_CAROLIEiJ_P0036228	Activin receptor type-1.	Bone morphogenetic protein receptor type-1A.	0.991
Aldh1a2	Cyp26a1	MGP_CAROLIEiJ_P0088556	MGP_CAROLIEiJ_P0048678	Retinal dehydrogenase 2.	Cytochrome P450 family 26 subfamily A.	0.972
Aldh1a2	Cyp26c1	MGP_CAROLIEiJ_P0088556	MGP_CAROLIEiJ_P0048677	Retinal dehydrogenase 2.	Cytochrome P450 family 26 subfamily C.	0.960
Aldh1a2	Rdh10	MGP_CAROLIEiJ_P0088556	MGP_CAROLIEiJ_P0016798	Retinal dehydrogenase 2.	Retinol dehydrogenase 10.	0.902
Bmpr1a	Acvr1	MGP_CAROLIEiJ_P0036228	MGP_CAROLIEiJ_P0051832	Bone morphogenetic protein receptor type-1A.	Activin receptor type-1.	0.991
Bmpr1a	Shh	MGP_CAROLIEiJ_P0036228	MGP_CAROLIEiJ_P0067069	Bone morphogenetic protein receptor type-1A.	Sonic hedgehog protein isoform X1.	0.428
Bmpr1a	Sox9	MGP_CAROLIEiJ_P0036228	MGP_CAROLIEiJ_P0030751	Bone morphogenetic protein receptor type-1A.	Transcription factor SOX9 (SOX group E).	0.417
Bmpr1a	Tapt1	MGP_CAROLIEiJ_P0036228	MGP_CAROLIEiJ_P0068043	Bone morphogenetic protein receptor type-1A.	Transmembrane anterior posterior transformation protein 1 homolog isoform X1.	0.430
Cdc42	Cdh2	MGP_CAROLIEiJ_P0065296	MGP_CAROLIEiJ_P0046112	Cell division control protein 42 homolog isoform X1.	Cadherin 2, type 1, N-cadherin.	0.752
Cdc42	Cfl1	MGP_CAROLIEiJ_P0065296	MGP_CAROLIEiJ_P0047634	Cell division control protein 42 homolog isoform X1.	Cofilin-1.	0.757
Cdc42	Edn1	MGP_CAROLIEiJ_P0065296	MGP_CAROLIEiJ_P0034179	Cell division control protein 42 homolog isoform X1.	Endothelin-1.	0.429
Cdc42	Efnb1	MGP_CAROLIEiJ_P0065296	MGP_CAROLIEiJ_P0092226	Cell division control protein 42 homolog isoform X1.	Ephrin-B1 isoform X1.	0.455
Cdc42	Erbb4	MGP_CAROLIEiJ_P0065296	MGP_CAROLIEiJ_P0018141	Cell division control protein 42 homolog isoform X1.	Receptor tyrosine-protein kinase erbB-4 isoform X1.	0.473
Cdc42	Mapk3	MGP_CAROLIEiJ_P0065296	MGP_CAROLIEiJ_P0082213	Cell division control protein 42 homolog isoform X1.	Mitogen-activated protein kinase 1/3.	0.659
Cdc42	Sema3a	MGP_CAROLIEiJ_P0065296	MGP_CAROLIEiJ_P0066714	Cell division control protein 42 homolog isoform X1.	Semaphorin-3A.	0.401
Cdh2	Cdc42	MGP_CAROLIEiJ_P0046112	MGP_CAROLIEiJ_P0065296	Cadherin 2, type 1, N-cadherin.	Cell division control protein 42 homolog isoform X1.	0.752
Cdh2	Fgf15	MGP_CAROLIEiJ_P0046112	MGP_CAROLIEiJ_P0083558	Cadherin 2, type 1, N-cadherin.	Fibroblast growth factor 19.	0.703
Cdh2	Fn1	MGP_CAROLIEiJ_P0046112	MGP_CAROLIEiJ_P0018183	Cadherin 2, type 1, N-cadherin.	Fibronectin 1.	0.428
Cdh2	Foxc2	MGP_CAROLIEiJ_P0046112	MGP_CAROLIEiJ_P0086290	Cadherin 2, type 1, N-cadherin.	Forkhead box protein C2.	0.517
Cdh2	Hif1a	MGP_CAROLIEiJ_P0046112	MGP_CAROLIEiJ_P0032540	Cadherin 2, type 1, N-cadherin.	Hypoxia-inducible factor 1-alpha isoform X1.	0.558