(90 nodes) Nerve development network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ngf	Nerve growth factor, beta. (307 aa)
	Dmd	Dystrophin isoform X1. (3678 aa)
	Plxna3	Plexin-A3 isoform X1. (1872 aa)
	Ctnnb1	Catenin beta 1. (781 aa)
	Dag1	Dystroglycan 1. (893 aa)
	Sema3f	Semaphorin-3F isoform X1. (785 aa)
	Ephb1	Ephrin type-B receptor 1 isoform X1. (984 aa)
	Nrp1	Neuropilin-1 isoform X1. (923 aa)
	Cngb1	Cyclic nucleotide-gated cation channel beta-1 isoform X1. (1311 aa)
	Sall1	Sal-like protein 1. (1322 aa)
	Ednra	Endothelin receptor type A. (427 aa)
	Unc13a	Protein unc-13 homolog A. (1733 aa)
	Ilk	Integrin-linked protein kinase. (452 aa)
	Phox2a	Paired mesoderm homeobox protein 2A. (280 aa)
	Gabrb3	Gamma-aminobutyric acid (GABA) A receptor, subunit beta 3. (507 aa)
	Gabra5	Gamma-aminobutyric acid receptor subunit alpha-5. (463 aa)
	Nav2	Neuron navigator 2. (2433 aa)
	Ntf5	Neurotrophin 4. (209 aa)
	Prkcg	Protein kinase C gamma type isoform X1. (697 aa)
	Ntf3	Neurotrophin-3 isoform X1. (271 aa)
	MGP_CAROLIEiJ_P0075713	annotation not available (1024 aa)
	Lrig1	Leucine-rich repeats and immunoglobulin-like domains protein 1. (1098 aa)
	Plxna1	Plexin-A1. (1912 aa)
	Hoxa3	Homeobox protein Hox-A3 isoform X1. (444 aa)
	Hoxa1	Homeobox protein Hox-A1 isoform X1. (336 aa)
	Plxna4	Plexin-A4 isoform X1. (1893 aa)
	Phox2b	Paired mesoderm homeobox protein 2B. (314 aa)
	Fgfr3	Fibroblast growth factor receptor 3. (802 aa)
	Mnx1	Motor neuron and pancreas homeobox protein 1. (404 aa)
	Sema3a	Semaphorin-3A. (772 aa)
	Hes3	Hairy and enhancer of split 3. (197 aa)
	Ece1	Endothelin-converting enzyme 1 isoform X1. (753 aa)
	Ephb2	Ephrin type-B receptor 2 isoform X1. (987 aa)
	Lpar1	Lysophosphatidic acid receptor 1 isoform X1. (364 aa)
	Unc13b	Protein unc-13 homolog B isoform X1. (1609 aa)
	Chd7	Chromodomain-helicase-DNA-binding protein 7. (2986 aa)
	Col25a1	Collagen alpha-1(XXV) chain isoform X1. (666 aa)
	Vcam1	Vascular cell adhesion molecule 1. (739 aa)
	Kcna2	Potassium voltage-gated channel Shaker-related subfamily A member 2. (499 aa)
	Lrig2	Leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1. (1054 aa)
	Chrnb2	Neuronal acetylcholine receptor subunit beta-2. (501 aa)
	Ntrk1	High affinity nerve growth factor receptor isoform X1. (799 aa)
	Sulf2	Extracellular sulfatase Sulf-2. (875 aa)
	Mafb	Transcription factor MAFB. (323 aa)
	Nkx2-2	Homeobox protein Nkx-2.2 isoform X1. (273 aa)
	Bdnf	LOW QUALITY PROTEIN: brain-derived neurotrophic factor. (289 aa)
	Itga4	Integrin alpha 4. (1032 aa)
	Hoxd3	Homeobox protein HoxA/B/D3. (433 aa)
	Pax2	Paired box 2. (416 aa)
	Tcirg1	V-type H+-transporting ATPase subunit a. (834 aa)
	Rnf165	E3 ubiquitin-protein ligase RNF165. (347 aa)
	Afg3l2	AFG3 family protein. (716 aa)
	Atp8b1	Phospholipid-transporting ATPase IC. (1251 aa)
	Pou4f3	POU domain, class 4, transcription factor 3. (338 aa)
	Slc25a46	Solute carrier family 25, member 46. (418 aa)
	Nrtn	Neurturin isoform X1. (195 aa)
	Rpl24	Large subunit ribosomal protein L24e. (157 aa)
	Fbxo45	F-box/SPRY domain-containing protein 1. (286 aa)
	Hes1	Hairy and enhancer of split 1. (281 aa)
	Tbx1	T-box transcription factor TBX1 isoform X1. (488 aa)
	Ext1	Glucuronyl/N-acetylglucosaminyl transferase EXT1. (746 aa)
	Slc1a3	Solute carrier family 1 (glial high affinity glutamate transporter), member 3. (543 aa)
	Slitrk6	SLIT and NTRK-like protein 6. (840 aa)
	Pou4f1	POU domain, class 4, transcription factor 1. (421 aa)
	Prrxl1	Dorsal root ganglia homeobox protein. (263 aa)
	Isl1	Insulin gene enhancer protein ISL-1 isoform X1. (349 aa)
	Ctsl	Cathepsin L2. (334 aa)
	Neurog1	Neurogenin 1. (244 aa)
	Tifab	TRAF-interacting protein with FHA domain-containing protein B. (147 aa)
	Edn1	Endothelin-1. (202 aa)
	Tfap2a	Transcription factor AP-2-alpha isoform X1. (440 aa)
	Gli3	Transcriptional activator GLI3. (1583 aa)
	Slc24a4	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4. (605 aa)
	Six4	Homeobox protein SIX4. (775 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	Nptx1	Neuronal pentraxin-1. (432 aa)
	Hoxb1	Homeobox protein HoxA/B/D1. (297 aa)
	Hoxb2	Homeobox protein HoxA/B2. (354 aa)
	Hoxb3	Homeobox protein Hox-B3 isoform X1. (435 aa)
	Ngfr	Tumor necrosis factor receptor superfamily member 16. (426 aa)
	Gabrb2	Gamma-aminobutyric acid receptor subunit beta-2 isoform X1. (512 aa)
	Erbb3	Receptor tyrosine-protein kinase erbB-3 isoform X1. (1339 aa)
	Adarb1	Double stranded RNA-specific editase B. (711 aa)
	Egr2	E3 SUMO-protein ligase EGR2 isoform X1. (470 aa)
	Atoh7	Protein atonal homolog 7. (149 aa)
	Cited2	Cbp/p300-interacting transactivator 2. (269 aa)
	Ackr3	C-X-C chemokine receptor type 7 (atypical chemokine receptor 3). (362 aa)
	Serpine2	Glia-derived nexin. (397 aa)
	Nrp2	Neuropilin-2 isoform X1. (931 aa)
	Sulf1	Extracellular sulfatase Sulf-1 isoform X1. (870 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atoh7	Isl1	MGP_CAROLIEiJ_P0023172	MGP_CAROLIEiJ_P0035531	Protein atonal homolog 7.	Insulin gene enhancer protein ISL-1 isoform X1.	0.574
Atoh7	Pou4f1	MGP_CAROLIEiJ_P0023172	MGP_CAROLIEiJ_P0037586	Protein atonal homolog 7.	POU domain, class 4, transcription factor 1.	0.594
Atoh7	Pou4f3	MGP_CAROLIEiJ_P0023172	MGP_CAROLIEiJ_P0046621	Protein atonal homolog 7.	POU domain, class 4, transcription factor 3.	0.501
Bdnf	Ctnnb1	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0090603	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Catenin beta 1.	0.503
Bdnf	Egr2	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0023210	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	E3 SUMO-protein ligase EGR2 isoform X1.	0.420
Bdnf	Erbb3	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0025178	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Receptor tyrosine-protein kinase erbB-3 isoform X1.	0.695
Bdnf	Fgfr3	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0067569	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Fibroblast growth factor receptor 3.	0.726
Bdnf	MGP_CAROLIEiJ_P0075713	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0075713	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	annotation not available	0.643
Bdnf	Ngf	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0059545	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Nerve growth factor, beta.	0.812
Bdnf	Ngfr	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0029374	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Tumor necrosis factor receptor superfamily member 16.	0.995
Bdnf	Nrp1	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0086608	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Neuropilin-1 isoform X1.	0.487
Bdnf	Nrtn	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0045377	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Neurturin isoform X1.	0.665
Bdnf	Ntf3	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0076163	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Neurotrophin-3 isoform X1.	0.877
Bdnf	Ntf5	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0079510	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Neurotrophin 4.	0.979
Bdnf	Ntrk1	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0058293	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	High affinity nerve growth factor receptor isoform X1.	0.989
Bdnf	Pou4f1	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0037586	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	POU domain, class 4, transcription factor 1.	0.456
Bdnf	Sema3a	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0066714	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Semaphorin-3A.	0.493
Bdnf	Slc1a3	MGP_CAROLIEiJ_P0053564	MGP_CAROLIEiJ_P0037805	LOW QUALITY PROTEIN: brain-derived neurotrophic factor.	Solute carrier family 1 (glial high affinity glutamate transporter), member 3.	0.521
Chd7	Ctnnb1	MGP_CAROLIEiJ_P0061371	MGP_CAROLIEiJ_P0090603	Chromodomain-helicase-DNA-binding protein 7.	Catenin beta 1.	0.564
Chd7	Tbx1	MGP_CAROLIEiJ_P0061371	MGP_CAROLIEiJ_P0040833	Chromodomain-helicase-DNA-binding protein 7.	T-box transcription factor TBX1 isoform X1.	0.452