(60 nodes) Positive regulation of epithelial cell differentiation network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Sfrp4	Secreted frizzled-related protein 4. (348 aa)
	Acvrl1	Serine/threonine-protein kinase receptor R3 isoform X1. (502 aa)
	Foxc1	Forkhead box protein C1. (553 aa)
	Bmp6	Bone morphogenetic protein 6. (508 aa)
	Macroh2a1	Core histone macro-H2A.1 isoform X1. (372 aa)
	Ptch1	Protein patched homolog 1. (1434 aa)
	Gdf2	Growth differentiation factor 2. (428 aa)
	Bmp4	Bone morphogenetic protein 4. (408 aa)
	Gdnf	Glial cell line-derived neurotrophic factor isoform X1. (240 aa)
	Commd5	COMM domain-containing protein 5. (224 aa)
	Vdr	Vitamin D3 receptor. (423 aa)
	Wnt10b	Wingless-type MMTV integration site family, member 10. (389 aa)
	Ctnnb1	Catenin beta 1. (781 aa)
	Numa1	Nuclear mitotic apparatus protein 1 isoform X1. (2092 aa)
	Mesp1	Mesoderm posterior protein 1. (244 aa)
	Sult2b1	Sulfotransferase family cytosolic 2B member 1 isoform X1. (372 aa)
	Etv2	ETS translocation variant 2 isoform X1. (335 aa)
	Foxa3	Forkhead box protein A3, hepatocyte nuclear factor 3-gamma. (353 aa)
	Atoh8	Protein atonal homolog 8. (322 aa)
	Atoh1	Protein atonal homolog 1. (351 aa)
	Pax4	Paired box protein Pax-4 isoform X1. (349 aa)
	Prom1	Prominin-1 isoform X1. (867 aa)
	Trp73	Tumor protein p73 isoform X1. (638 aa)
	Sfn	14-3-3 protein sigma. (248 aa)
	Kdf1	Keratinocyte differentiation factor 1. (397 aa)
	Ptch2	Protein patched homolog 2 isoform X1. (1182 aa)
	Skint1	Selection and upkeep of intraepithelial T-cells protein 1. (364 aa)
	Cdkn2b	Cyclin-dependent kinase 4 inhibitor B. (130 aa)
	Fgf2	Fibroblast growth factor 2 isoform X1. (154 aa)
	Sox2	Transcription factor SOX2 (SOX group B). (319 aa)
	Bmp7	Bone morphogenetic protein 7. (430 aa)
	Ncoa3	Nuclear receptor coactivator 3 isoform X1. (1399 aa)
	Nkx2-2	Homeobox protein Nkx-2.2 isoform X1. (273 aa)
	Ovol2	Transcription factor Ovo-like 2 isoform X1. (274 aa)
	Bmp2	Bone morphogenetic protein 2. (394 aa)
	Pax6	Paired box protein Pax-6 isoform X1. (436 aa)
	Zeb2	Zinc finger E-box-binding homeobox 2. (1259 aa)
	Notch1	Neurogenic locus notch homolog protein 1. (2531 aa)
	Pax8	Paired box protein Pax-8. (457 aa)
	Pax2	Paired box 2. (416 aa)
	Rfx3	Transcription factor RFX3 isoform X1. (783 aa)
	Bad	BCL2 associated agonist of cell death. (204 aa)
	Ahi1	Jouberin isoform X1. (1047 aa)
	Cd24a	Signal transducer CD24. (76 aa)
	Macroh2a2	Core histone macro-H2A.2. (372 aa)
	Btg1	Protein Tob/BTG. (171 aa)
	Cyp27b1	Calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase). (508 aa)
	Lif	Leukemia inhibitory factor isoform X1. (203 aa)
	Wnt9a	Wingless-type MMTV integration site family, member 9. (365 aa)
	Trim16	Tripartite motif-containing protein 16. (557 aa)
	Alox8	Arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type). (677 aa)
	Foxn1	Forkhead box protein N1 isoform X1. (648 aa)
	Lhx1	LIM/homeobox protein Lhx1. (406 aa)
	Vezf1	Vascular endothelial zinc finger 1. (517 aa)
	Tmem100	Transmembrane protein 100. (134 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1 isoform X1. (1583 aa)
	Etv4	ETS translocation variant 4 isoform X1. (486 aa)
	Sox9	Transcription factor SOX9 (SOX group E). (507 aa)
	Foxj1	Forkhead box protein J1. (421 aa)
	Prkch	Protein kinase C eta type isoform X1. (683 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acvrl1	Bmp2	MGP_CAROLIEiJ_P0039896	MGP_CAROLIEiJ_P0054833	Serine/threonine-protein kinase receptor R3 isoform X1.	Bone morphogenetic protein 2.	0.688
Acvrl1	Bmp4	MGP_CAROLIEiJ_P0039896	MGP_CAROLIEiJ_P0036330	Serine/threonine-protein kinase receptor R3 isoform X1.	Bone morphogenetic protein 4.	0.866
Acvrl1	Bmp6	MGP_CAROLIEiJ_P0039896	MGP_CAROLIEiJ_P0034136	Serine/threonine-protein kinase receptor R3 isoform X1.	Bone morphogenetic protein 6.	0.634
Acvrl1	Bmp7	MGP_CAROLIEiJ_P0039896	MGP_CAROLIEiJ_P0056456	Serine/threonine-protein kinase receptor R3 isoform X1.	Bone morphogenetic protein 7.	0.594
Acvrl1	Fgf2	MGP_CAROLIEiJ_P0039896	MGP_CAROLIEiJ_P0057426	Serine/threonine-protein kinase receptor R3 isoform X1.	Fibroblast growth factor 2 isoform X1.	0.441
Acvrl1	Gdf2	MGP_CAROLIEiJ_P0039896	MGP_CAROLIEiJ_P0036206	Serine/threonine-protein kinase receptor R3 isoform X1.	Growth differentiation factor 2.	0.999
Ahi1	Ctnnb1	MGP_CAROLIEiJ_P0022447	MGP_CAROLIEiJ_P0090603	Jouberin isoform X1.	Catenin beta 1.	0.501
Atoh1	Notch1	MGP_CAROLIEiJ_P0074116	MGP_CAROLIEiJ_P0050383	Protein atonal homolog 1.	Neurogenic locus notch homolog protein 1.	0.528
Atoh1	Pax2	MGP_CAROLIEiJ_P0074116	MGP_CAROLIEiJ_P0048929	Protein atonal homolog 1.	Paired box 2.	0.558
Atoh1	Pax6	MGP_CAROLIEiJ_P0074116	MGP_CAROLIEiJ_P0053507	Protein atonal homolog 1.	Paired box protein Pax-6 isoform X1.	0.414
Atoh1	Sox2	MGP_CAROLIEiJ_P0074116	MGP_CAROLIEiJ_P0057315	Protein atonal homolog 1.	Transcription factor SOX2 (SOX group B).	0.558
Bad	Sfn	MGP_CAROLIEiJ_P0047909	MGP_CAROLIEiJ_P0064970	BCL2 associated agonist of cell death.	14-3-3 protein sigma.	0.664
Bmp2	Acvrl1	MGP_CAROLIEiJ_P0054833	MGP_CAROLIEiJ_P0039896	Bone morphogenetic protein 2.	Serine/threonine-protein kinase receptor R3 isoform X1.	0.688
Bmp2	Bmp4	MGP_CAROLIEiJ_P0054833	MGP_CAROLIEiJ_P0036330	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.935
Bmp2	Bmp6	MGP_CAROLIEiJ_P0054833	MGP_CAROLIEiJ_P0034136	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.955
Bmp2	Bmp7	MGP_CAROLIEiJ_P0054833	MGP_CAROLIEiJ_P0056456	Bone morphogenetic protein 2.	Bone morphogenetic protein 7.	0.734
Bmp2	Ctnnb1	MGP_CAROLIEiJ_P0054833	MGP_CAROLIEiJ_P0090603	Bone morphogenetic protein 2.	Catenin beta 1.	0.591
Bmp2	Fgf2	MGP_CAROLIEiJ_P0054833	MGP_CAROLIEiJ_P0057426	Bone morphogenetic protein 2.	Fibroblast growth factor 2 isoform X1.	0.707
Bmp2	Gdf2	MGP_CAROLIEiJ_P0054833	MGP_CAROLIEiJ_P0036206	Bone morphogenetic protein 2.	Growth differentiation factor 2.	0.489
Bmp2	Notch1	MGP_CAROLIEiJ_P0054833	MGP_CAROLIEiJ_P0050383	Bone morphogenetic protein 2.	Neurogenic locus notch homolog protein 1.	0.428