(51 nodes) T cell selection network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Bcl2	Apoptosis regulator Bcl-2. (236 aa)
	Zap70	Tyrosine-protein kinase ZAP-70 isoform X1. (618 aa)
	Cd28	T-cell-specific surface glycoprotein CD28. (219 aa)
	Ctla4	Cytotoxic T-lymphocyte protein 4 isoform X1. (222 aa)
	Ptprc	Receptor-type tyrosine-protein phosphatase C. (1302 aa)
	Ly9	T-lymphocyte surface antigen Ly-9 isoform X1. (653 aa)
	Slamf6	SLAM family member 6 isoform X1. (332 aa)
	Itpkb	1D-myo-inositol-triphosphate 3-kinase. (942 aa)
	Themis	Protein THEMIS isoform X1. (636 aa)
	Atg5	Autophagy-related protein 5. (275 aa)
	Aire	Autoimmune regulator isoform X1. (552 aa)
	Stk11	Serine/threonine-protein kinase STK11 isoform X1. (441 aa)
	Stat6	Signal transducer and activator of transcription 6. (837 aa)
	Dock2	Dedicator of cytokinesis protein 2. (1828 aa)
	Il4	Interleukin 4. (140 aa)
	Mink1	Misshapen like kinase 1. (1374 aa)
	Tbx21	T-box transcription factor TBX21. (530 aa)
	Ccr7	C-C chemokine receptor type 7. (378 aa)
	Stat3	Signal transducer and activator of transcription 3 isoform X1. (770 aa)
	Batf	ATF-like basic leucine zipper transcriptional factor. (125 aa)
	Bcl11b	B-cell lymphoma/leukemia 11B isoform X1. (884 aa)
	Jag2	Protein jagged-2. (1247 aa)
	Gli3	Transcriptional activator GLI3. (1583 aa)
	Irf4	Interferon regulatory factor 4 isoform X1. (450 aa)
	Syk	Tyrosine-protein kinase SYK. (629 aa)
	Ctsl	Cathepsin L2. (334 aa)
	H2-DMa	Class II histocompatibility antigen, M alpha chain. (261 aa)
	Btnl1	Butyrophilin-like protein 1. (509 aa)
	Srf	Serum response factor. (504 aa)
	Cd74	HLA class II histocompatibility antigen gamma chain isoform X1. (331 aa)
	Fas	Tumor necrosis factor receptor superfamily member 6 isoform X1. (327 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (443 aa)
	Cd1d	Antigen-presenting glycoprotein CD1d. (150 aa)
	Il6ra	Interleukin-6 receptor subunit alpha isoform X1. (460 aa)
	Tox	Thymocyte selection-associated high mobility group box protein TOX. (526 aa)
	Skint1	Selection and upkeep of intraepithelial T-cells protein 1. (364 aa)
	Mtor	Serine/threonine-protein kinase mTOR. (2549 aa)
	Shh	Sonic hedgehog protein isoform X1. (438 aa)
	Il6	Interleukin 6. (211 aa)
	Card11	Caspase recruitment domain-containing protein 11. (1154 aa)
	Braf	B-Raf proto-oncogene serine/threonine-protein kinase. (804 aa)
	Cd4	T-cell surface glycoprotein CD4 isoform X1. (457 aa)
	Tgfb1	Transforming growth factor beta-1. (390 aa)
	Spn	Leukosialin. (386 aa)
	Il15	Interleukin 15. (162 aa)
	Cyld	Ubiquitin carboxyl-terminal hydrolase CYLD. (955 aa)
	Cd3g	T-cell surface glycoprotein CD3 gamma chain. (182 aa)
	Cd3d	T-cell surface glycoprotein CD3 delta chain isoform X1. (173 aa)
	Cd3e	T-cell surface glycoprotein CD3 epsilon chain. (189 aa)
	Foxp3	Forkhead box protein P3 isoform X1. (428 aa)
	Otud5	OTU domain-containing protein 5 isoform X1. (571 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aire	Cd4	MGP_CAROLIEiJ_P0023625	MGP_CAROLIEiJ_P0076043	Autoimmune regulator isoform X1.	T-cell surface glycoprotein CD4 isoform X1.	0.584
Aire	Foxp3	MGP_CAROLIEiJ_P0023625	MGP_CAROLIEiJ_P0090803	Autoimmune regulator isoform X1.	Forkhead box protein P3 isoform X1.	0.571
Aire	Ptprc	MGP_CAROLIEiJ_P0023625	MGP_CAROLIEiJ_P0020154	Autoimmune regulator isoform X1.	Receptor-type tyrosine-protein phosphatase C.	0.400
Atg5	Bcl2	MGP_CAROLIEiJ_P0022818	MGP_CAROLIEiJ_P0019368	Autophagy-related protein 5.	Apoptosis regulator Bcl-2.	0.727
Atg5	Cd4	MGP_CAROLIEiJ_P0022818	MGP_CAROLIEiJ_P0076043	Autophagy-related protein 5.	T-cell surface glycoprotein CD4 isoform X1.	0.412
Atg5	Il6	MGP_CAROLIEiJ_P0022818	MGP_CAROLIEiJ_P0067110	Autophagy-related protein 5.	Interleukin 6.	0.454
Atg5	Mtor	MGP_CAROLIEiJ_P0022818	MGP_CAROLIEiJ_P0065783	Autophagy-related protein 5.	Serine/threonine-protein kinase mTOR.	0.677
Atg5	Stat3	MGP_CAROLIEiJ_P0022818	MGP_CAROLIEiJ_P0029936	Autophagy-related protein 5.	Signal transducer and activator of transcription 3 isoform X1.	0.429
Batf	Bcl11b	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0033294	ATF-like basic leucine zipper transcriptional factor.	B-cell lymphoma/leukemia 11B isoform X1.	0.447
Batf	Cd4	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0076043	ATF-like basic leucine zipper transcriptional factor.	T-cell surface glycoprotein CD4 isoform X1.	0.494
Batf	Foxp3	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0090803	ATF-like basic leucine zipper transcriptional factor.	Forkhead box protein P3 isoform X1.	0.523
Batf	Gata3	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0049509	ATF-like basic leucine zipper transcriptional factor.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.594
Batf	Il4	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0026641	ATF-like basic leucine zipper transcriptional factor.	Interleukin 4.	0.416
Batf	Il6	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0067110	ATF-like basic leucine zipper transcriptional factor.	Interleukin 6.	0.417
Batf	Irf4	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0034020	ATF-like basic leucine zipper transcriptional factor.	Interferon regulatory factor 4 isoform X1.	0.784
Batf	Stat3	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0029936	ATF-like basic leucine zipper transcriptional factor.	Signal transducer and activator of transcription 3 isoform X1.	0.704
Batf	Stat6	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0025053	ATF-like basic leucine zipper transcriptional factor.	Signal transducer and activator of transcription 6.	0.493
Batf	Tbx21	MGP_CAROLIEiJ_P0032903	MGP_CAROLIEiJ_P0029505	ATF-like basic leucine zipper transcriptional factor.	T-box transcription factor TBX21.	0.605
Bcl11b	Batf	MGP_CAROLIEiJ_P0033294	MGP_CAROLIEiJ_P0032903	B-cell lymphoma/leukemia 11B isoform X1.	ATF-like basic leucine zipper transcriptional factor.	0.447
Bcl11b	Cd4	MGP_CAROLIEiJ_P0033294	MGP_CAROLIEiJ_P0076043	B-cell lymphoma/leukemia 11B isoform X1.	T-cell surface glycoprotein CD4 isoform X1.	0.469