(14 nodes) Positive thymic T cell selection network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2-DMa	Class II histocompatibility antigen, M alpha chain. (261 aa)
	Srf	Serum response factor. (504 aa)
	Zap70	Tyrosine-protein kinase ZAP-70 isoform X1. (618 aa)
	Dock2	Dedicator of cytokinesis protein 2. (1828 aa)
	Stk11	Serine/threonine-protein kinase STK11 isoform X1. (441 aa)
	Shh	Sonic hedgehog protein isoform X1. (438 aa)
	Cd3g	T-cell surface glycoprotein CD3 gamma chain. (182 aa)
	Cd3d	T-cell surface glycoprotein CD3 delta chain isoform X1. (173 aa)
	Cd3e	T-cell surface glycoprotein CD3 epsilon chain. (189 aa)
	Cd1d	Antigen-presenting glycoprotein CD1d. (150 aa)
	Cd74	HLA class II histocompatibility antigen gamma chain isoform X1. (331 aa)
	Skint1	Selection and upkeep of intraepithelial T-cells protein 1. (364 aa)
	Itpkb	1D-myo-inositol-triphosphate 3-kinase. (942 aa)
	Ptprc	Receptor-type tyrosine-protein phosphatase C. (1302 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd1d	Cd3d	MGP_CAROLIEiJ_P0058241	MGP_CAROLIEiJ_P0087613	Antigen-presenting glycoprotein CD1d.	T-cell surface glycoprotein CD3 delta chain isoform X1.	0.513
Cd1d	Cd3e	MGP_CAROLIEiJ_P0058241	MGP_CAROLIEiJ_P0087614	Antigen-presenting glycoprotein CD1d.	T-cell surface glycoprotein CD3 epsilon chain.	0.731
Cd1d	Cd3g	MGP_CAROLIEiJ_P0058241	MGP_CAROLIEiJ_P0087610	Antigen-presenting glycoprotein CD1d.	T-cell surface glycoprotein CD3 gamma chain.	0.413
Cd1d	Ptprc	MGP_CAROLIEiJ_P0058241	MGP_CAROLIEiJ_P0020154	Antigen-presenting glycoprotein CD1d.	Receptor-type tyrosine-protein phosphatase C.	0.630
Cd3d	Cd1d	MGP_CAROLIEiJ_P0087613	MGP_CAROLIEiJ_P0058241	T-cell surface glycoprotein CD3 delta chain isoform X1.	Antigen-presenting glycoprotein CD1d.	0.513
Cd3d	Cd3e	MGP_CAROLIEiJ_P0087613	MGP_CAROLIEiJ_P0087614	T-cell surface glycoprotein CD3 delta chain isoform X1.	T-cell surface glycoprotein CD3 epsilon chain.	0.999
Cd3d	Cd3g	MGP_CAROLIEiJ_P0087613	MGP_CAROLIEiJ_P0087610	T-cell surface glycoprotein CD3 delta chain isoform X1.	T-cell surface glycoprotein CD3 gamma chain.	0.999
Cd3d	Ptprc	MGP_CAROLIEiJ_P0087613	MGP_CAROLIEiJ_P0020154	T-cell surface glycoprotein CD3 delta chain isoform X1.	Receptor-type tyrosine-protein phosphatase C.	0.768
Cd3d	Zap70	MGP_CAROLIEiJ_P0087613	MGP_CAROLIEiJ_P0017165	T-cell surface glycoprotein CD3 delta chain isoform X1.	Tyrosine-protein kinase ZAP-70 isoform X1.	0.994
Cd3e	Cd1d	MGP_CAROLIEiJ_P0087614	MGP_CAROLIEiJ_P0058241	T-cell surface glycoprotein CD3 epsilon chain.	Antigen-presenting glycoprotein CD1d.	0.731
Cd3e	Cd3d	MGP_CAROLIEiJ_P0087614	MGP_CAROLIEiJ_P0087613	T-cell surface glycoprotein CD3 epsilon chain.	T-cell surface glycoprotein CD3 delta chain isoform X1.	0.999
Cd3e	Cd3g	MGP_CAROLIEiJ_P0087614	MGP_CAROLIEiJ_P0087610	T-cell surface glycoprotein CD3 epsilon chain.	T-cell surface glycoprotein CD3 gamma chain.	0.999
Cd3e	Ptprc	MGP_CAROLIEiJ_P0087614	MGP_CAROLIEiJ_P0020154	T-cell surface glycoprotein CD3 epsilon chain.	Receptor-type tyrosine-protein phosphatase C.	0.847
Cd3e	Zap70	MGP_CAROLIEiJ_P0087614	MGP_CAROLIEiJ_P0017165	T-cell surface glycoprotein CD3 epsilon chain.	Tyrosine-protein kinase ZAP-70 isoform X1.	0.998
Cd3g	Cd1d	MGP_CAROLIEiJ_P0087610	MGP_CAROLIEiJ_P0058241	T-cell surface glycoprotein CD3 gamma chain.	Antigen-presenting glycoprotein CD1d.	0.413
Cd3g	Cd3d	MGP_CAROLIEiJ_P0087610	MGP_CAROLIEiJ_P0087613	T-cell surface glycoprotein CD3 gamma chain.	T-cell surface glycoprotein CD3 delta chain isoform X1.	0.999
Cd3g	Cd3e	MGP_CAROLIEiJ_P0087610	MGP_CAROLIEiJ_P0087614	T-cell surface glycoprotein CD3 gamma chain.	T-cell surface glycoprotein CD3 epsilon chain.	0.999
Cd3g	Ptprc	MGP_CAROLIEiJ_P0087610	MGP_CAROLIEiJ_P0020154	T-cell surface glycoprotein CD3 gamma chain.	Receptor-type tyrosine-protein phosphatase C.	0.683
Cd3g	Zap70	MGP_CAROLIEiJ_P0087610	MGP_CAROLIEiJ_P0017165	T-cell surface glycoprotein CD3 gamma chain.	Tyrosine-protein kinase ZAP-70 isoform X1.	0.990
Cd74	H2-DMa	MGP_CAROLIEiJ_P0046833	MGP_CAROLIEiJ_P0044160	HLA class II histocompatibility antigen gamma chain isoform X1.	Class II histocompatibility antigen, M alpha chain.	0.994